GB899556A - Substituted isonicotinic acid amides and process for their manufacture - Google Patents

Substituted isonicotinic acid amides and process for their manufacture

Info

Publication number
GB899556A
GB899556A GB20266/59A GB2026659A GB899556A GB 899556 A GB899556 A GB 899556A GB 20266/59 A GB20266/59 A GB 20266/59A GB 2026659 A GB2026659 A GB 2026659A GB 899556 A GB899556 A GB 899556A
Authority
GB
United Kingdom
Prior art keywords
isonicotinic acid
propylamine
diphenyl
reacting
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20266/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB899556A publication Critical patent/GB899556A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0899556/IV (b)/1> wherein R1 is a halogen atom or a methyl or methoxy group, R2 and R3 are hydrogen or halogen atoms, and R4 is a halogen atom) and their preparation by reacting isonicotinic acid or a reactive derivative thereof with the appropriately substituted 2,3-diphenyl-propylamine. Suitable reactive derivatives include halides and esters of isonicotinic acid, or the process may be effected by heating the salt of isonicotinic acid with the diphenyl-propylamine at 270 DEG C.-320 DEG C. until no more water is split off. Examples are given. Starting materials of the formula <FORM:0899556/IV (b)/2> are prepared by reacting an appropriately substituted benzaldehyde or benzyl halide, in the presence of an alkaline condensing agent, with a substituted benzyl cyanide and then reducing the products. The amides of the invention, which are stated to be cytostatic agents, may be formulated as pharmaceutical preparations with suitable carriers. Tablets, capsules, dragees, ampoules, solutions and suspensions are referred to, and these may contain stabilizers, buffers, wetting agents, emulsifiers or salts for regulating the osmotic pressure.
GB20266/59A 1958-06-12 1959-06-12 Substituted isonicotinic acid amides and process for their manufacture Expired GB899556A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF25947A DE1223388B (en) 1958-06-12 1958-06-12 Process for the preparation of new isonicotinic acid amides

Publications (1)

Publication Number Publication Date
GB899556A true GB899556A (en) 1962-06-27

Family

ID=7091829

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20266/59A Expired GB899556A (en) 1958-06-12 1959-06-12 Substituted isonicotinic acid amides and process for their manufacture

Country Status (4)

Country Link
BE (1) BE579630A (en)
CH (1) CH375357A (en)
DE (1) DE1223388B (en)
GB (1) GB899556A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003087037A1 (en) * 2002-04-05 2003-10-23 Merck & Co., Inc. Substituted aryl amides
US7348456B2 (en) 2002-12-19 2008-03-25 Merck & Co., Inc. Substituted amides

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003087037A1 (en) * 2002-04-05 2003-10-23 Merck & Co., Inc. Substituted aryl amides
US7348456B2 (en) 2002-12-19 2008-03-25 Merck & Co., Inc. Substituted amides
US7576239B2 (en) 2002-12-19 2009-08-18 Merck & Co., Inc. Substituted amides

Also Published As

Publication number Publication date
CH375357A (en) 1964-02-29
BE579630A (en) 1959-12-14
DE1223388B (en) 1966-08-25

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