GB807902A - Improvements in or relating to derivatives of quercetin and to processes for their preparation - Google Patents
Improvements in or relating to derivatives of quercetin and to processes for their preparationInfo
- Publication number
- GB807902A GB807902A GB26151/56A GB2615156A GB807902A GB 807902 A GB807902 A GB 807902A GB 26151/56 A GB26151/56 A GB 26151/56A GB 2615156 A GB2615156 A GB 2615156A GB 807902 A GB807902 A GB 807902A
- Authority
- GB
- United Kingdom
- Prior art keywords
- quercetin
- mono
- ether
- tertiary
- ascorbate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
b -Tertiary-aminoethyl mono ethers of quercetin (3,5,7,31,41-pentahydroxy flavone), their acid addition and quaternary ammonium salts, having Vitamin P activity, are prepared by heating quercetin in aqueous alkaline medium, in an inert atmosphere, with a b -tertiary aminoethyl halide (or its hydrohalide salt), neutralizing the reaction mixture, and separating the mono-ether from the quercetin in the precipitate thus formed. The tertiary amino group is of formula -NR1R2 wherein R1 and R2 repre sent lower alkyl groups, each containing at most six carbon atoms, or together with the N atom from a heterocyclic ring of five or six members. In examples: (1) quercetin monohydrate in aqueous NaOH is stirred at 80-90 DEG C. under nitrogen with b -morpholinoethyl chloride hydrochloride in aqueous NaOH, the mixture acidified and the b -morpholinoethyl mono ether separated from the dried precipitate thus obtained by extraction with boiling acetone; it is converted (3) into the ascorbate by treatment with methanolic ascorbic acid; and (5) into the methiodide by treatment in acetone with MeI; (2) and (4) as in (1) and (3) respectively but using b -diethylaminoethyl chloride hydrochloride to give the corresponding mono-ether and its ascorbate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR807902X | 1955-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB807902A true GB807902A (en) | 1959-01-21 |
Family
ID=9252689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26151/56A Expired GB807902A (en) | 1955-08-29 | 1956-08-27 | Improvements in or relating to derivatives of quercetin and to processes for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB807902A (en) |
-
1956
- 1956-08-27 GB GB26151/56A patent/GB807902A/en not_active Expired
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