GB991485A - Phenyl-indolyl-aminoalkanols - Google Patents

Phenyl-indolyl-aminoalkanols

Info

Publication number
GB991485A
GB991485A GB3521462A GB3521462A GB991485A GB 991485 A GB991485 A GB 991485A GB 3521462 A GB3521462 A GB 3521462A GB 3521462 A GB3521462 A GB 3521462A GB 991485 A GB991485 A GB 991485A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
halogen
alkyl
ketone
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3521462A
Inventor
Robert Cornelis Roozemond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nv Koninklijke Pharmaceutische Fabriken V/h Brocades Stheeman & Pharmacia
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Nv Koninklijke Pharmaceutische Fabriken V/h Brocades Stheeman & Pharmacia
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nv Koninklijke Pharmaceutische Fabriken V/h Brocades Stheeman & Pharmacia, Koninklijke Pharmaceutische Fabrieken NV filed Critical Nv Koninklijke Pharmaceutische Fabriken V/h Brocades Stheeman & Pharmacia
Priority to GB3521462A priority Critical patent/GB991485A/en
Publication of GB991485A publication Critical patent/GB991485A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0991485/C2/1> where R1 is hydrogen, halogen or alkoxy, R2 is hydrogen, alkyl or aralkyl, R3 is hydrogen or alkyl, R4 is hydrogen, halogen, alkoxy, alkyl or trifluoromethyl, A is C3-6 alkylene and B is alkylamino or dialkylamino, or a saturated mononuclear 5- or 6-membered heterocyclic group attached via a nitrogen atom; acid addition salts thereof; and their preparations by reacting an appropriate indolyl phenyl ketone with a compound BAMgX (where X is halogen) and hydrolysing the product. Indol-3-yl o-tolyl ketone and p-tolyl ketone are prepared from indole and o- and p-toluyl chloride respectively, in the presence of ethyl magnesium iodide. Indol-3-yl m-tolyl ketone is prepared from indole, m-toluylic acid dimethylamide and POCl3. The compounds of the invention and their non-toxic acid addition salts possess antiallergic and sedative properties, and are employed in pharmaceutical preparations with a pharmacologically acceptable carrier. They may be administered orally, e.g. as tablets, pills, capsules, suspensions, emulsions, syrups or elixirs, or parenterally.
GB3521462A 1962-09-14 1962-09-14 Phenyl-indolyl-aminoalkanols Expired GB991485A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3521462A GB991485A (en) 1962-09-14 1962-09-14 Phenyl-indolyl-aminoalkanols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3521462A GB991485A (en) 1962-09-14 1962-09-14 Phenyl-indolyl-aminoalkanols

Publications (1)

Publication Number Publication Date
GB991485A true GB991485A (en) 1965-05-12

Family

ID=10375164

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3521462A Expired GB991485A (en) 1962-09-14 1962-09-14 Phenyl-indolyl-aminoalkanols

Country Status (1)

Country Link
GB (1) GB991485A (en)

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