GB986906A - Ethers of indolyl-benzyl alcohols - Google Patents

Abstract

The invention comprises compounds of formula <FORM:0986906/C2/1> and non-toxic acid addition salts thereof, where R1 is hydrogen, halogen or alkoxy, R2 is hydrogen, halogen or alkoxy, R2 is hydrogen, alkyl or aralkyl, R3 is hydrogen or alkyl, R4 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl, R5 is hydrogen or alkyl, A is C2- 6 alkylene, and B is alkylamino or dialkylamino, or a saturated mononuclear 5- or 6-membered heterocyclic group attached to A by a nitrogen atom; and their preparation by reacting the corresponding substituted benzyl alcohol with BA.OH, or an alkali metal derivative of the benzyl alcohol with BA.Halogen, or a corresponding benzyl halide with BA.OH or an alkali metal derivative thereof; or (when R2 is alkyl or aralkyl) by reacting an amino BH with an appropriate haloalkyl ether of the substituted benzyl alcohol. a - (1 - Methylindol - 3 - yl) - benzyl alcohol and its o-, m- and p-methyl and o-ethyl homologues are prepared from 1-methylindol-3-yl aldehyde and the appropriate phenyllithium; a - (1 - methylindol - 2 - yl) - benzyl alcohol and a - (1 - methylindol - 2 - yl) - a - methylbenzyl alcohol and their o-, m- and p-methyl derivatives are prepared similarly. The compounds of the invention possess antiallergic and sedative properties and are employed in pharmaceutical preparations with a pharmacologically acceptable carrier, especially for oral administration, such as tablets, pills and capsules, suspensions, emulsions, syrups and elixirs, or for parenteral administration.