GB1036278A - Piperidine derivatives - Google Patents
Piperidine derivativesInfo
- Publication number
- GB1036278A GB1036278A GB50224/63A GB5022463A GB1036278A GB 1036278 A GB1036278 A GB 1036278A GB 50224/63 A GB50224/63 A GB 50224/63A GB 5022463 A GB5022463 A GB 5022463A GB 1036278 A GB1036278 A GB 1036278A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydrogen atom
- compounds
- alkyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:1036278/C2/1> wherein R1 is a phenyl group, R2 is a group -COR4, wherein R4 is a hydrogen atom or an alkyl, aralkyl, alkoxy, dialkylaminoalkoxy, amino or hydroxyalkyl group, and R3 is a hydrogen atom or an alkanoyl group, or R3 is a R3 in combination form a group <FORM:1036278/C2/2> wherein R5 and R6 are alkyl radicals and Y is a carbonyl or methylene group, and acid addition salts of compounds wherein R3 is a hydrogen atom, and their preparation by (a) reaction of a compound of the above formula, wherein R2 is a hydrogen atom with a reactive functional derivative of a carboxylic acid or with an alkali metal cyanate, (b) reduction of a carbonyl group Y to a methylene group, (c) tranesterifying an alkyl - N - (4 - hydroxy - 4 - phenyl - 1 - piperidine) carbamate with a dialkylaminoalcohol, or (d) treatment of a succinimide with lithium aluminium hydride to form a 4-hydroxy-butyramide. The compounds of the invention have antidepressant activity and may be used in pharmaceutical compositions in combination with a pharmaceutical carrier, for example in forms suitable for oral, parenteral or rectal administration, such as tablets, capsules, solutions and suppositories.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB50224/63A GB1036278A (en) | 1963-12-19 | 1963-12-19 | Piperidine derivatives |
DE19641445469 DE1445469A1 (en) | 1963-12-19 | 1964-12-14 | Process for the preparation of piperidine derivatives |
FR999305A FR4006M (en) | 1963-12-19 | 1964-12-19 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB50224/63A GB1036278A (en) | 1963-12-19 | 1963-12-19 | Piperidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1036278A true GB1036278A (en) | 1966-07-20 |
Family
ID=10455140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB50224/63A Expired GB1036278A (en) | 1963-12-19 | 1963-12-19 | Piperidine derivatives |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1445469A1 (en) |
FR (1) | FR4006M (en) |
GB (1) | GB1036278A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1896415A1 (en) * | 2005-06-08 | 2008-03-12 | NeuroSearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
-
1963
- 1963-12-19 GB GB50224/63A patent/GB1036278A/en not_active Expired
-
1964
- 1964-12-14 DE DE19641445469 patent/DE1445469A1/en active Pending
- 1964-12-19 FR FR999305A patent/FR4006M/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR4006M (en) | 1966-03-14 |
DE1445469A1 (en) | 1969-01-23 |
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