GB8827391D0 - Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride - Google Patents

Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Info

Publication number
GB8827391D0
GB8827391D0 GB888827391A GB8827391A GB8827391D0 GB 8827391 D0 GB8827391 D0 GB 8827391D0 GB 888827391 A GB888827391 A GB 888827391A GB 8827391 A GB8827391 A GB 8827391A GB 8827391 D0 GB8827391 D0 GB 8827391D0
Authority
GB
United Kingdom
Prior art keywords
zinyl
pipera
phenylmethyl
dihydrochloride
chlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB888827391A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB888827391A priority Critical patent/GB8827391D0/en
Publication of GB8827391D0 publication Critical patent/GB8827391D0/en
Priority to CA000614709A priority patent/CA1317300C/en
Priority to GR890100770A priority patent/GR1000553B/el
Priority to GB8926243A priority patent/GB2225321B/en
Priority to PT92364A priority patent/PT92364B/pt
Priority to HU896131A priority patent/HU205094B/hu
Priority to NO894651A priority patent/NO172342C/no
Priority to FI895564A priority patent/FI91862C/fi
Priority to AT0266589A priority patent/AT398971B/de
Priority to ES8903975A priority patent/ES2021907A6/es
Priority to PL1989282410A priority patent/PL161379B1/pl
Priority to DK198905867A priority patent/DK174543B1/da
Priority to KR1019890017040A priority patent/KR970009728B1/ko
Priority to PH39570A priority patent/PH25982A/en
Priority to SG894/92A priority patent/SG89492G/en
Priority to HK958/92A priority patent/HK95892A/xx
Priority to CY1671A priority patent/CY1671A/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB888827391A 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride Pending GB8827391D0 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
CA000614709A CA1317300C (en) 1988-11-23 1989-09-29 Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl) phenylmethyl|-1-piperazinyl|ethoxy|-acetic acid and its dihydrochloride
GR890100770A GR1000553B (el) 1988-11-23 1989-11-20 Μεθοδος παρασκευης του 2-(2-(4-((4-χλωριοφαινυλ)φαινυλμεθυλ)-1-πιπεραζινυλ)αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατιου του.
GB8926243A GB2225321B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
PT92364A PT92364B (pt) 1988-11-23 1989-11-21 Processo para a preparacao de acido 2-{2-{(4-cloridrato)- fenilmetil}-1- -piperazinil}etoxi}-acetico e do seu cloridrato
DK198905867A DK174543B1 (da) 1988-11-23 1989-11-22 Fremgangsmåde til fremstilling af 2-[2-[4-[[(4-chlorphenyl)phenylmethyl)]-1-piperazinyl]ethoxy]eddikesyre og dens dihydrochlorid og udgangsforbindelse til anvendelse ved fremgangsmåden
AT0266589A AT398971B (de) 1988-11-23 1989-11-22 Verfahren zur herstellung der 2-(2-(4-((4-chlor- phenyl)-phenylmethyl)-1-piperazinyl)ethoxy)- essigsäure und ihres dichlorhydrats
NO894651A NO172342C (no) 1988-11-23 1989-11-22 Fremgangsmaate for fremstilling av 2-(2-(4-((4-klorfenyl)-fenylmethyl)-1-piperazinyl)-ethoxy)-eddiksyre og dens dihydroklorid, og mellomprodukt for anvendelse ved fremgangsmaaten
FI895564A FI91862C (fi) 1988-11-23 1989-11-22 2-/2-/4-/(4-kloorifenyyli)fenyylimetyyli/-1-piperatsinyyli/etoksi/-etikkahapon ja sen dihydrokloridin valmistusmenetelmä
HU896131A HU205094B (en) 1988-11-23 1989-11-22 New process for producing 2-/2-/4-/(4-chlorophenyl)-phenylmethyl/-1-piperazinyl/-ethoxy/-acetic acid and its salts
ES8903975A ES2021907A6 (es) 1988-11-23 1989-11-22 Procedimiento de preparacion del acido 2-(2-(-4( (4-clorofenil) fenilmetil)-1-piperazinil)etoxi)acetico y de su dihidrocloruro".
PL1989282410A PL161379B1 (pl) 1988-11-23 1989-11-22 S p o só b wytwarzania kwasu 2-[2-[4-[/4-chlorofenylo/fenylom etylo]-1-piperazynylo] etoksy]octow ego i jego dichlorowodorku PL PL
KR1019890017040A KR970009728B1 (ko) 1988-11-23 1989-11-23 2-[2-[4-[(4-클로로페닐)페닐메틸]-1-피페라지닐]에톡시]-아세트산 및 그의 중염산염의 제조방법
PH39570A PH25982A (en) 1988-11-23 1989-11-23 A process for the preparation of 2-(2-((4-chlorophenyl) phenyl-methyl)-1-piperazinyl) ethoxy) acetic acid and its dihydrochloride
SG894/92A SG89492G (en) 1988-11-23 1992-09-05 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
HK958/92A HK95892A (en) 1988-11-23 1992-12-03 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
CY1671A CY1671A (en) 1988-11-23 1993-05-14 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
GB8827391D0 true GB8827391D0 (en) 1988-12-29

Family

ID=10647347

Family Applications (2)

Application Number Title Priority Date Filing Date
GB888827391A Pending GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8926243A Expired - Lifetime GB2225321B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8926243A Expired - Lifetime GB2225321B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Country Status (16)

Country Link
KR (1) KR970009728B1 (de)
AT (1) AT398971B (de)
CA (1) CA1317300C (de)
CY (1) CY1671A (de)
DK (1) DK174543B1 (de)
ES (1) ES2021907A6 (de)
FI (1) FI91862C (de)
GB (2) GB8827391D0 (de)
GR (1) GR1000553B (de)
HK (1) HK95892A (de)
HU (1) HU205094B (de)
NO (1) NO172342C (de)
PH (1) PH25982A (de)
PL (1) PL161379B1 (de)
PT (1) PT92364B (de)
SG (1) SG89492G (de)

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DE10199031I2 (de) * 1992-09-24 2004-09-23 Sepracor Inc Verwendung von (-) Cetrizin zur Behandlung allergischer Rhinitis und Asthma.
ATE177636T1 (de) * 1992-09-24 1999-04-15 Sepracor Inc Transdermale behandlung der nesselsucht mit optisch reinem (+)-cetirizin
AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
JP3476475B2 (ja) 1997-06-04 2003-12-10 株式会社アズウェル ピペラジンスルホンアミド誘導体およびその塩の製造方法
EP0919550A1 (de) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphische Formen der 2-2-4-Bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxyessigsäure Dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (el) * 1999-04-22 2000-12-29 Genepharm �.�. Μεθοδος παρασκευης του 2-(2-[4-[4-χλωροφαινυλο)(φαινυλο)μεθυλο]πιπεραζινο]αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατος αυτου
JP2002249487A (ja) * 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd ４−（ｔｅｒｔ−ブトキシカルボニル）ピペラジン誘導体、その光学活性な酸付加塩、それらの製造法、およびそれらを用いる光学活性な１−［（置換フェニル）フェニルメチル］ピペラジンの製造法。
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
CN100378086C (zh) * 2003-01-23 2008-04-02 Ucb法奇姆股份有限公司 哌嗪衍生物和它们作为合成中间体的应用
KR100503443B1 (ko) 2004-02-02 2005-07-22 한림제약(주) 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
AU2006222298B2 (en) * 2005-03-03 2011-02-24 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
WO2008110586A2 (en) 2007-03-12 2008-09-18 Krka, Tovarna Zdravil, D.D., Novo Mesto New process for the preparation of levocetirizine and intermediates thereof
SI22489A (sl) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za pripravo levocetirizina in njegovih intermediatov
EP2167479B1 (de) 2007-06-15 2013-09-11 Symed Labs Limited Verfahren zur herstellung von weitgehend optisch reinen levorotatorischen und dextrorotatorischen enantiomeren von cetirizin mittels neuer zwischenprodukte
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
EP2062881B1 (de) 2007-11-21 2011-02-23 Synthon B.V. Verfahren zur Herstellung von N-(Diphenylmethyl)piperazinen
NZ589492A (en) 2008-06-02 2012-06-29 Cipla Ltd Processes for the synthesis of levocetirizine and intermediates for use therein
EP2297122B1 (de) * 2008-06-11 2014-05-21 KRKA, tovarna zdravil, d.d., Novo mesto Neues verfahren zur herstellung von levocetirizin und zwischenprodukten davon
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
TR201007652A2 (tr) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Sinerjik etki.
TR201009398A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Fiziksel özellikleri geliştirilmiş tablet formülasyonları
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
CN103044355A (zh) * 2011-10-13 2013-04-17 湖南九典制药有限公司 合成左西替利嗪的关键中间体及其制备方法
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
CN104045607B (zh) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 一种盐酸西替利嗪的纯化方法
CN105924409B (zh) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 一种(r)-1-((2-氯苯基)-(苯基)-甲基)-哌嗪的拆分方法
CN111205247B (zh) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 左旋西替利嗪的制备方法

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NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.

Also Published As

Publication number Publication date
GR890100770A (en) 1990-12-31
PH25982A (en) 1992-01-13
PT92364A (pt) 1990-05-31
KR900007825A (ko) 1990-06-02
CY1671A (en) 1993-05-14
ATA266589A (de) 1994-07-15
DK174543B1 (da) 2003-05-19
GB2225321B (en) 1992-04-08
CA1317300C (en) 1993-05-04
ES2021907A6 (es) 1991-11-16
NO172342B (no) 1993-03-29
AT398971B (de) 1995-02-27
DK586789A (da) 1990-05-24
HK95892A (en) 1992-12-11
NO894651D0 (no) 1989-11-22
GB8926243D0 (en) 1990-01-10
NO172342C (no) 1993-07-07
HU896131D0 (en) 1990-02-28
PL161379B1 (pl) 1993-06-30
NO894651L (no) 1990-05-25
KR970009728B1 (ko) 1997-06-17
PT92364B (pt) 1995-07-18
FI91862B (fi) 1994-05-13
GR1000553B (el) 1992-08-26
GB2225321A (en) 1990-05-30
HUT53627A (en) 1990-11-28
SG89492G (en) 1992-12-04
FI91862C (fi) 1994-08-25
FI895564A0 (fi) 1989-11-22
HU205094B (en) 1992-03-30
DK586789D0 (da) 1989-11-22

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