GB875060A - N,n-disubstituted ª--aminoalkylethers of alcohols of the aromatic-aliphatic series and a process for the production thereof - Google Patents
N,n-disubstituted ª--aminoalkylethers of alcohols of the aromatic-aliphatic series and a process for the production thereofInfo
- Publication number
- GB875060A GB875060A GB18840/60A GB1884060A GB875060A GB 875060 A GB875060 A GB 875060A GB 18840/60 A GB18840/60 A GB 18840/60A GB 1884060 A GB1884060 A GB 1884060A GB 875060 A GB875060 A GB 875060A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aminoalkylethers
- disubstituted
- alcohols
- aromatic
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001298 alcohols Chemical class 0.000 title 1
- 229940066768 systemic antihistamines aminoalkyl ethers Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical group C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- -1 dimethylamino, diethylamino, piperidino Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Abstract
The invention comprises compounds of the formula <FORM:0875060/IV (b)/1> in which R1 represents a dimethylamino, diethylamino, piperidino or morpholino radical; and acid addition salts thereof; and the preparation thereof by reacting 4-chloro-a -methylbenzhydrol with a compound of the formula Hal.CH(CH3).CH2R1, wherein Hal represents a halogen atom, in the presence of sodamide; and, if desired, converting the products into their acid addition salts. The products have antihistaminic and anticholinergic activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEA32142A DE1122544B (en) | 1959-05-30 | 1959-05-30 | Process for the preparation of new histamine-antagonistically active aminoalkyl ethers |
Publications (1)
Publication Number | Publication Date |
---|---|
GB875060A true GB875060A (en) | 1961-08-16 |
Family
ID=6927707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB18840/60A Expired GB875060A (en) | 1959-05-30 | 1960-05-27 | N,n-disubstituted ª--aminoalkylethers of alcohols of the aromatic-aliphatic series and a process for the production thereof |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE591071A (en) |
CH (1) | CH386448A (en) |
DE (1) | DE1122544B (en) |
FR (1) | FR280M (en) |
GB (1) | GB875060A (en) |
NL (1) | NL252001A (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1094069A (en) * | 1953-08-24 | 1955-05-11 | Fond D Equipement De L Hygiene | Process for obtaining ethers-oxides of benzhydrols and aminoalcohols |
-
0
- NL NL252001D patent/NL252001A/xx unknown
-
1959
- 1959-05-30 DE DEA32142A patent/DE1122544B/en active Pending
-
1960
- 1960-05-20 BE BE591071A patent/BE591071A/en unknown
- 1960-05-25 CH CH603060A patent/CH386448A/en unknown
- 1960-05-27 GB GB18840/60A patent/GB875060A/en not_active Expired
- 1960-08-24 FR FR828484A patent/FR280M/en active Active
Also Published As
Publication number | Publication date |
---|---|
NL252001A (en) | |
DE1122544B (en) | 1962-01-25 |
CH386448A (en) | 1965-01-15 |
BE591071A (en) | 1960-09-16 |
FR280M (en) | 1961-03-13 |
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