GB857546A - Trifluoromethyl-phenothiazine derivatives - Google Patents
Trifluoromethyl-phenothiazine derivativesInfo
- Publication number
- GB857546A GB857546A GB37978/56A GB3797856A GB857546A GB 857546 A GB857546 A GB 857546A GB 37978/56 A GB37978/56 A GB 37978/56A GB 3797856 A GB3797856 A GB 3797856A GB 857546 A GB857546 A GB 857546A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenthiazine
- reacting
- appropriate
- compounds
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AZSIPSZDDPHYPD-UHFFFAOYSA-N 1-(trifluoromethyl)-10h-phenothiazine Chemical class S1C2=CC=CC=C2NC2=C1C=CC=C2C(F)(F)F AZSIPSZDDPHYPD-UHFFFAOYSA-N 0.000 title 1
- WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- -1 alkylene radical Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000007800 oxidant agent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- DCGSQPPAWRQVPS-UHFFFAOYSA-N 2-[4-chloro-1-[4-chloro-2-(oxan-2-yl)butoxy]butan-2-yl]oxane Chemical compound O1C(CCCC1)C(COCC(CCCl)C1OCCCC1)CCCl DCGSQPPAWRQVPS-UHFFFAOYSA-N 0.000 abstract 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US857546XA | 1955-12-23 | 1955-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB857546A true GB857546A (en) | 1960-12-29 |
Family
ID=22193722
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31044/60A Expired GB857547A (en) | 1955-12-23 | 1956-12-12 | Trifluoromethyl-phenothiazine derivatives |
| GB37978/56A Expired GB857546A (en) | 1955-12-23 | 1956-12-12 | Trifluoromethyl-phenothiazine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31044/60A Expired GB857547A (en) | 1955-12-23 | 1956-12-12 | Trifluoromethyl-phenothiazine derivatives |
Country Status (5)
| Country | Link |
|---|---|
| CY (1) | CY280A (enrdf_load_stackoverflow) |
| DE (1) | DE1095836B (enrdf_load_stackoverflow) |
| FR (1) | FR1209854A (enrdf_load_stackoverflow) |
| GB (2) | GB857547A (enrdf_load_stackoverflow) |
| NL (1) | NL106170C (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017222466A1 (en) * | 2016-06-23 | 2017-12-28 | Bioimics Ab | Anti-infective heterocyclic compounds and uses thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL108827C (enrdf_load_stackoverflow) * | 1956-04-09 | |||
| GB1517385A (en) * | 1975-08-29 | 1978-07-12 | Eisai Co Ltd | Phenothiazine derivatives |
| US8637503B2 (en) | 2003-05-16 | 2014-01-28 | Board Of Regents, The University Of Texas System | Phenothiazine enantiomers as agents for the prevention of bone loss |
| JP2010502621A (ja) | 2006-09-01 | 2010-01-28 | イミユーン・コントロール・インコーポレーテツド | リンパ球の活性化に関連した病気を治療するための新規な組成物および方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE910301C (de) * | 1950-12-21 | 1954-04-29 | Rhone Poulenc Sa | Verfahren zur Herstellung von neuen Phenthiazinderivaten |
-
0
- NL NL106170D patent/NL106170C/xx active
-
1956
- 1956-04-27 FR FR1209854D patent/FR1209854A/fr not_active Expired
- 1956-12-08 DE DEO5235A patent/DE1095836B/de active Pending
- 1956-12-12 GB GB31044/60A patent/GB857547A/en not_active Expired
- 1956-12-12 GB GB37978/56A patent/GB857546A/en not_active Expired
-
1964
- 1964-03-18 CY CY28064A patent/CY280A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017222466A1 (en) * | 2016-06-23 | 2017-12-28 | Bioimics Ab | Anti-infective heterocyclic compounds and uses thereof |
| CN109641889A (zh) * | 2016-06-23 | 2019-04-16 | 百欧伊米克思有限公司 | 抗感染杂环化合物及其用途 |
| JP2019518771A (ja) * | 2016-06-23 | 2019-07-04 | バイオイミクス・アクチボラグ | 抗感染症複素環式化合物およびその使用 |
| US11130741B2 (en) | 2016-06-23 | 2021-09-28 | Bioimics Ab | Anti-infective heterocyclic compounds and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1209854A (fr) | 1960-03-04 |
| NL106170C (enrdf_load_stackoverflow) | |
| DE1095836B (de) | 1960-12-29 |
| CY280A (en) | 1964-03-18 |
| GB857547A (en) | 1960-12-29 |
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