GB723748A - Steroid - Google Patents

Steroid

Info

Publication number
GB723748A
GB723748A GB17179/52A GB1717952A GB723748A GB 723748 A GB723748 A GB 723748A GB 17179/52 A GB17179/52 A GB 17179/52A GB 1717952 A GB1717952 A GB 1717952A GB 723748 A GB723748 A GB 723748A
Authority
GB
United Kingdom
Prior art keywords
dihydroxyprogesterone
oxidation
hydroxy
bromacetamide
ketoprogesterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17179/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB723748A publication Critical patent/GB723748A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 6-hydroxy-11-ketoprogesterone, and the preparation thereof by reacting 6,11-dihydroxyprogesterone and an oxidizing agent, e.g. potassium permanganate, N-bromacetamide in tertiary butanol or chromic acid, the quantities of reactants being such that there is present not more than approximately 1 gram atom of available oxygen per gram mol. of 6,11-dihydroxyprogesterone, whereby oxidation of the hydroxy group at the 11-position of the starting material is brought about without causing oxidation elsewhere in the molecule. 6,11,a - dihydroxyprogesterone is obtained by oxygenating progesterone by means of Rhizopus arrhizus ATTCC 11145.
GB17179/52A 1952-03-25 1952-07-08 Steroid Expired GB723748A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US723748XA 1952-03-25 1952-03-25

Publications (1)

Publication Number Publication Date
GB723748A true GB723748A (en) 1955-02-09

Family

ID=22107156

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17179/52A Expired GB723748A (en) 1952-03-25 1952-07-08 Steroid

Country Status (1)

Country Link
GB (1) GB723748A (en)

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