ES368909A1 - Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)
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Merck KGaA
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E Merck AG
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Priority to ES368909ApriorityCriticalpatent/ES368909A1/en
Publication of ES368909A1publicationCriticalpatent/ES368909A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Procedure for the preparation of 9alpha-fluor-16-methylene-prednisolone or -prednisone and its 21-esters, characterized in that 9beta-11beta-oxide-l6-methylene-4-pregnen-17alpha-ol-3,20-dione it is dehydrogenated microbiologically in position 1 (2), then the 9beta, 11beta-oxide-l6-methylene-l, 4-pregnadiene-17alpha-ol-3,20-dione obtained is reacted with hydrofluoric acid and because the 9alpha-fluorine -16-methylene-l, 4-pregnadiene-11beta, -17alpha-diol-3,20-dione thus prepared is treated with iodine in alkaline solution and then with an alkaline acetate, and because in the 21-acetate of 9alpha-fluorine -6-methylene-prednisolone obtained, the group 11-oh is optionally transformed by treatment with an oxidizing agent in a group 11-keto and/or the group 21-acetoxy is saponified by treatment with a saponification agent under formation of 9alpha -fluor-l6-methylene-prednisolone or-prednisone as well as eventually these compounds are transformed by treatment with an agent esterification in its 21-esters. (Machine-translation by Google Translate, not legally binding)
ES368909A1969-06-281969-06-28Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)
ExpiredES368909A1
(en)
Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)
Novel processes for preparing steroid compounds, the comopounds when thus prepared, novel steroid compounds thereby prepared, and pharmaceutical compositions containing the novel compounds
Procedure for the preparation of the steroid 21-acetate of 16-alpha, 17-alpha-ciclopentilidendioxi-3,20-oliona (Machine-translation by Google Translate, not legally binding)
Analogous process for the preparation of anti-inflammatory 21-apocamphan-1-carboxylic acid esters of 17α, 21-dihydroxy-Δ <4> -pregne-3,20-diones.