GB695518A - Selective oxidation of dihydroxy steroids - Google Patents
Selective oxidation of dihydroxy steroidsInfo
- Publication number
- GB695518A GB695518A GB19221/51A GB1922151A GB695518A GB 695518 A GB695518 A GB 695518A GB 19221/51 A GB19221/51 A GB 19221/51A GB 1922151 A GB1922151 A GB 1922151A GB 695518 A GB695518 A GB 695518A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydroxy
- selective oxidation
- keto
- pyridine
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
D 17 - 3,21 - dihydroxy - 11 - keto - 20 - cyanopregnenes are selectively oxidized at the 3-hydroxy grouping without affecting the hydroxy group in the 21-position by reacting said D 17-3,21 - dihydroxy - 11 - keto - 20 - cyanopregnene with N-halogen-substituted carboxylic acid amides or imides, e.g. N-bromoacetamide or N-bromosuccinimide. The reaction may be effected using methanol, tertiary butanol, pyridine or a mixture of methanol and pyridine in the temperature range 18 DEG and 40 DEG C. and at a pH of 6 to 7.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US695518XA | 1950-09-16 | 1950-09-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB695518A true GB695518A (en) | 1953-08-12 |
Family
ID=22089738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB19221/51A Expired GB695518A (en) | 1950-09-16 | 1951-08-15 | Selective oxidation of dihydroxy steroids |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB695518A (en) |
-
1951
- 1951-08-15 GB GB19221/51A patent/GB695518A/en not_active Expired
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