GB973899A - Novel steroid compounds and their preparation - Google Patents
Novel steroid compounds and their preparationInfo
- Publication number
- GB973899A GB973899A GB399364A GB399364A GB973899A GB 973899 A GB973899 A GB 973899A GB 399364 A GB399364 A GB 399364A GB 399364 A GB399364 A GB 399364A GB 973899 A GB973899 A GB 973899A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ketal
- epoxy
- methyl
- pregn
- dione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises the 3-ketals of 11b ,18-epoxy-18#x-methyl-pregn-4-en-3-one compounds having the formula <FORM:0973899/C1/1> in which R represents a ketal grouping, and R1 represents the grouping =H(OH) and R2 is hydrogen or R1 represents the oxygen atom =O of a keto group and R2 is a hydrogen atom, the ethoxalyl grouping or an iodine atom, and processes for the preparation thereof by saponifying a ketal of 18#x-methyl-20b -acetoxy-11b , 18-epoxy-pregn-4-en-3-one to form the 3-ketal of 18#x-methyl-20b -hydroxy-11b , 18-epoxy-pregn-4-en-3-one, oxidizing the latter to form the corresponding 20-keto compounds, reacting the 3-ketal of 18#x-methyl-11b , 18-epoxy-pregn-4-ene-3, 20-dione with ethyl oxalate to form the corresponding 3-ketal of 18#x-methyl-21-ethoxalyl-11b , 18-epoxy-pregn-4-ene-3, 20-dione, iodinating this compound to form the corresponding 3-ketal of 18#x-methyl-21-iodo-11b , 18-epoxy-pregn-4-ene-3, 20-dione, reacting this with an acyloxylating agent to yield the corresponding 3-ketal of 18#x-methyl-21-acyloxy-11b , 18-epoxy-4-ene-3, 20-dione which is optionally saponified. As acyloxylating agent there may be employed potassium acetate and as oxidizing agent chromium trioxide may be employed. Specification 973,896 also is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR843959A FR1366720A (en) | 1960-11-15 | 1960-11-15 | New 18-Oxygenated Pregnane Series Derivatives and Method of Preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB973899A true GB973899A (en) | 1964-10-28 |
Family
ID=8742696
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB399364A Expired GB973899A (en) | 1960-11-15 | 1961-11-15 | Novel steroid compounds and their preparation |
GB4092261A Expired GB973897A (en) | 1960-11-15 | 1961-11-15 | New 18-oxygenated pregnane steroids and processes for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4092261A Expired GB973897A (en) | 1960-11-15 | 1961-11-15 | New 18-oxygenated pregnane steroids and processes for their preparation |
Country Status (3)
Country | Link |
---|---|
CH (1) | CH404660A (en) |
FR (1) | FR1366720A (en) |
GB (2) | GB973899A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53317U (en) * | 1976-06-22 | 1978-01-05 |
-
1960
- 1960-11-15 FR FR843959A patent/FR1366720A/en not_active Expired
-
1961
- 1961-11-13 CH CH1314561A patent/CH404660A/en unknown
- 1961-11-15 GB GB399364A patent/GB973899A/en not_active Expired
- 1961-11-15 GB GB4092261A patent/GB973897A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53317U (en) * | 1976-06-22 | 1978-01-05 |
Also Published As
Publication number | Publication date |
---|---|
FR1366720A (en) | 1964-07-17 |
GB973897A (en) | 1964-10-28 |
CH404660A (en) | 1965-12-31 |
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