GB694688A - New chemotherapeutic thiosemicarbazones - Google Patents

New chemotherapeutic thiosemicarbazones

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Publication number
GB694688A
GB694688A GB16141/51A GB1614151A GB694688A GB 694688 A GB694688 A GB 694688A GB 16141/51 A GB16141/51 A GB 16141/51A GB 1614151 A GB1614151 A GB 1614151A GB 694688 A GB694688 A GB 694688A
Authority
GB
United Kingdom
Prior art keywords
cinnamaldehyde
thiosemicarbazide
prepared
reacting
cinnamalthiosemicarbazone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB16141/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB694688A publication Critical patent/GB694688A/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0694688/IV (b)/1> in which R is an acylamino, nitro, carboxy, carboalkoxy, carboxyalkyleneoxy, or alkylsulphone group. The compounds are prepared by reacting thiosemicarbazide with the corresponding arylalkenyl aldehyde. In examples: (1) 4-nitrocinnamaldehyde is refluxed with thiosemicarbazide in alcohol, and the 4-nitrocinnamalthiosemicarbazone formed is reduced with iron and acetic acid to form 4-aminocinnamalthiosemicarbazone which is then acetylated with acetic anhydride in cyclohexanone; (2) 4-ethylsulphone-cinnamaldehyde-thiosemicarbazone is made from thiosemicarbazide and 4-ethylsulphone-cinnamaldehyde (prepared by reacting 4-ethylsulphonebenzaldehyde with acetaldehyde in alcoholic alkali); (3) 4-carbomethoxy-cinnamaldehyde (made by reacting methyl 4-formylbenzoate with acetaldehyde in alcoholic caustic potash) is treated with thiosemicarbazide to yield 4-carbomethoxy - cinnamalthiosemicarbazone which may then be saponified to 4-carboxycinnamalthiosemicarbazone; and (4) 4-carboxymethyleneoxy - cinnamalthiosemicarbazone is prepared from 4-carboxymethyleneoxy-cinnamaldehyde and thiosemicarbazone.
GB16141/51A 1950-07-06 1951-07-06 New chemotherapeutic thiosemicarbazones Expired GB694688A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE694688X 1950-07-06

Publications (1)

Publication Number Publication Date
GB694688A true GB694688A (en) 1953-07-22

Family

ID=6606829

Family Applications (1)

Application Number Title Priority Date Filing Date
GB16141/51A Expired GB694688A (en) 1950-07-06 1951-07-06 New chemotherapeutic thiosemicarbazones

Country Status (1)

Country Link
GB (1) GB694688A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102702058A (en) * 2009-10-27 2012-10-03 厦门大学 Preparation method of 4-methoxy-cinnamaldehyde thiosemicarbazone

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102702058A (en) * 2009-10-27 2012-10-03 厦门大学 Preparation method of 4-methoxy-cinnamaldehyde thiosemicarbazone

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