GB694688A - New chemotherapeutic thiosemicarbazones - Google Patents
New chemotherapeutic thiosemicarbazonesInfo
- Publication number
- GB694688A GB694688A GB16141/51A GB1614151A GB694688A GB 694688 A GB694688 A GB 694688A GB 16141/51 A GB16141/51 A GB 16141/51A GB 1614151 A GB1614151 A GB 1614151A GB 694688 A GB694688 A GB 694688A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cinnamaldehyde
- thiosemicarbazide
- prepared
- reacting
- cinnamalthiosemicarbazone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0694688/IV (b)/1> in which R is an acylamino, nitro, carboxy, carboalkoxy, carboxyalkyleneoxy, or alkylsulphone group. The compounds are prepared by reacting thiosemicarbazide with the corresponding arylalkenyl aldehyde. In examples: (1) 4-nitrocinnamaldehyde is refluxed with thiosemicarbazide in alcohol, and the 4-nitrocinnamalthiosemicarbazone formed is reduced with iron and acetic acid to form 4-aminocinnamalthiosemicarbazone which is then acetylated with acetic anhydride in cyclohexanone; (2) 4-ethylsulphone-cinnamaldehyde-thiosemicarbazone is made from thiosemicarbazide and 4-ethylsulphone-cinnamaldehyde (prepared by reacting 4-ethylsulphonebenzaldehyde with acetaldehyde in alcoholic alkali); (3) 4-carbomethoxy-cinnamaldehyde (made by reacting methyl 4-formylbenzoate with acetaldehyde in alcoholic caustic potash) is treated with thiosemicarbazide to yield 4-carbomethoxy - cinnamalthiosemicarbazone which may then be saponified to 4-carboxycinnamalthiosemicarbazone; and (4) 4-carboxymethyleneoxy - cinnamalthiosemicarbazone is prepared from 4-carboxymethyleneoxy-cinnamaldehyde and thiosemicarbazone.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE694688X | 1950-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB694688A true GB694688A (en) | 1953-07-22 |
Family
ID=6606829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB16141/51A Expired GB694688A (en) | 1950-07-06 | 1951-07-06 | New chemotherapeutic thiosemicarbazones |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB694688A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102702058A (en) * | 2009-10-27 | 2012-10-03 | 厦门大学 | Preparation method of 4-methoxy-cinnamaldehyde thiosemicarbazone |
-
1951
- 1951-07-06 GB GB16141/51A patent/GB694688A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102702058A (en) * | 2009-10-27 | 2012-10-03 | 厦门大学 | Preparation method of 4-methoxy-cinnamaldehyde thiosemicarbazone |
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