GB601624A - Improvements in or relating to processes of producing a dicarboxylic acid derivativeof a sulphathiazole - Google Patents
Improvements in or relating to processes of producing a dicarboxylic acid derivativeof a sulphathiazoleInfo
- Publication number
- GB601624A GB601624A GB22342/45A GB2234245A GB601624A GB 601624 A GB601624 A GB 601624A GB 22342/45 A GB22342/45 A GB 22342/45A GB 2234245 A GB2234245 A GB 2234245A GB 601624 A GB601624 A GB 601624A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphathiazole
- ketone
- water
- acetone
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
2 - (N4 - Carboxyacylamino - benzenesulphon - amido) thiazoles are prepared by reacting maleic or succinic or phthalic anhydride with sulphathiazole, or 4-alkyl-sulphathiazole or 2-sulphanilamido-4-5-6-7-tetrahydrobenzothiazole in the presence of a ketone or a mixture of ketones as a solvent. It is preferred that the reaction should take place at a temperature below 60 DEG C., and also that the ketone acid is one which is liquid at 30 DEG C. Ketones mentioned as suitable include acetone, methyl ethyl ketone, methyl propyl ketone, methyl isopropyl ketone, other isomeric pentanones, and the isomeric hexanones and heptanones. Before isolating the reaction product it is preferred to add a small amount of water. In the case of the succinyl derivative, this results in the product being obtained in the form of the monohydrate. In examples: (1) equimolecular amounts of sulphathiazole and succinic anhydride are refluxed in acetone, after which water is added and the acetone distilled off. The product is N4-succinyl-sulphathiazole monohydrate; (2) as in example (1) but omitting the addition of water; (3) equimolecular amounts of sulphathiazole and phthalic anhydride are refluxed and water added as in example (1) to form anhydrous N4-phthalylsulphathiazole. This is purified with charcoal in aqueous alkaline solution.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US601624XA | 1942-09-10 | 1942-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB601624A true GB601624A (en) | 1948-05-10 |
Family
ID=22027770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB22342/45A Expired GB601624A (en) | 1942-09-10 | 1945-08-30 | Improvements in or relating to processes of producing a dicarboxylic acid derivativeof a sulphathiazole |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB601624A (en) |
-
1945
- 1945-08-30 GB GB22342/45A patent/GB601624A/en not_active Expired
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