GB632576A - Improvements in and relating to the purification of penicillin - Google Patents
Improvements in and relating to the purification of penicillinInfo
- Publication number
- GB632576A GB632576A GB2564946A GB2564946A GB632576A GB 632576 A GB632576 A GB 632576A GB 2564946 A GB2564946 A GB 2564946A GB 2564946 A GB2564946 A GB 2564946A GB 632576 A GB632576 A GB 632576A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- glycol
- extracted
- solvent
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/18—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
In the recovery and purification of penicillin contained in a hydrophobic organic solvent, i.e. an organic solvent for penicillin which is insoluble or substantially insoluble in water such as a hydrocarbon, chlorinated hydrocarbon, ether, ester, higher alcohol or higher ketone, the penicillin is extracted from solution with a hydrophilic solvent, which is substantially immiscible with the said hydrophobic solvent and Which is an ether alcohol or polyhydric alcoho containing not more than 3 hydroxyl groups. In place of the hydrophilic solvent an aqueous solution thereof may be used. Suitably, the extraction is carried out using 50-90 per cent aqueous ethylene glycol or diethylene glycol at a pH of 4-7 and the resulting solution of penicillin in aqueous ethylene or diethylene glycol is diluted with water to a 10-40 per cent concentration of hydrophilic solvent and is re-extracted with a hydrophobic solvent at a pH of 1-5. In examples (1) and (2) penicillin in ether is extracted with 80 per cent aqueous glycol and the glycol solution is acidified, diluted and extracted with chloroform; (3) diethylene glycol is used in place of glycol in the process of (1); and (4) an amyl acetate extract of penicillin is treated as in (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2564946A GB632576A (en) | 1946-08-27 | 1946-08-27 | Improvements in and relating to the purification of penicillin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2564946A GB632576A (en) | 1946-08-27 | 1946-08-27 | Improvements in and relating to the purification of penicillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB632576A true GB632576A (en) | 1949-11-28 |
Family
ID=10231097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2564946A Expired GB632576A (en) | 1946-08-27 | 1946-08-27 | Improvements in and relating to the purification of penicillin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB632576A (en) |
-
1946
- 1946-08-27 GB GB2564946A patent/GB632576A/en not_active Expired
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