GB1074742A - Penicillin-placenta extract complex - Google Patents

Penicillin-placenta extract complex

Info

Publication number
GB1074742A
GB1074742A GB2308364A GB2308364A GB1074742A GB 1074742 A GB1074742 A GB 1074742A GB 2308364 A GB2308364 A GB 2308364A GB 2308364 A GB2308364 A GB 2308364A GB 1074742 A GB1074742 A GB 1074742A
Authority
GB
United Kingdom
Prior art keywords
placenta
penicillin
complex
precipitate
liquid extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2308364A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOUIS WOLF GRANIRER
Original Assignee
LOUIS WOLF GRANIRER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOUIS WOLF GRANIRER filed Critical LOUIS WOLF GRANIRER
Publication of GB1074742A publication Critical patent/GB1074742A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A penicillin-placenta complex is produced by contacting penicillin with a pharmaceutically-acceptable salt complex of an extract of placenta derived by contacting placenta with an acidic alcoholic solvent to form a liquid extract and adding to the liquid extract a base so as to precipitate a salt complex. In the example, human placenta is treated with aqueous ethyl alcohol at pH 2.7 at 20-30 DEG C., allowed to stand to precipitate proteins and NH4OH added to pH 9.6. The precipitate so formed is washed with water, dissolved in saline and mixed with an aqueous procaine penicillin G suspension. A preservative is added to the mixture so formed. A reaction is thought to take place between the penicillin and the placenta complex. The preparation has a prolonged action penicillin effect.ALSO:A medicinal placenta complex is obtained by contacting mamalian placenta, e.g. human placenta, with an acidic alcoholic solvent to form a liquid extract and adding to the liquid extract a base to a pH above 7 so as to precipitate a salt complex. In the example, human placenta is treated with aqueous ethyl alcohol of pH 2.7 at 20-30 DEG C., allowed to stand to precipitate proteins and NH4OH added to pH 9.6. The precipitate so formed is washed with water, dissolved in saline and mixed with an aqueous procaine penicillin G suspension (see Heading C2A). The complex produced has a prolonged action penicillin effect.
GB2308364A 1963-07-31 1963-03-22 Penicillin-placenta extract complex Expired GB1074742A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29911463A 1963-07-31 1963-07-31

Publications (1)

Publication Number Publication Date
GB1074742A true GB1074742A (en) 1967-07-05

Family

ID=23153366

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2308364A Expired GB1074742A (en) 1963-07-31 1963-03-22 Penicillin-placenta extract complex

Country Status (2)

Country Link
DE (2) DE1467908A1 (en)
GB (1) GB1074742A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124900A (en) * 1982-12-10 1984-02-29 Cubana Importadora Y Exportado Product for stimulating the synthesis of melanotic pigment in the skin

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2303529A1 (en) * 1975-03-10 1976-10-08 Florent Joseph Metal or metalloid contg. animal placenta cosmetics - obtd. by heating finely divided tissue with powdered metal or metalloid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124900A (en) * 1982-12-10 1984-02-29 Cubana Importadora Y Exportado Product for stimulating the synthesis of melanotic pigment in the skin

Also Published As

Publication number Publication date
DE1467909A1 (en) 1970-05-14
DE1467908A1 (en) 1970-05-14

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