GB623789A - Improvements in or relating to a method for producing 5:6-dimethoxy-8-aminoquinoline - Google Patents

Improvements in or relating to a method for producing 5:6-dimethoxy-8-aminoquinoline

Info

Publication number
GB623789A
GB623789A GB8274/47A GB827447A GB623789A GB 623789 A GB623789 A GB 623789A GB 8274/47 A GB8274/47 A GB 8274/47A GB 827447 A GB827447 A GB 827447A GB 623789 A GB623789 A GB 623789A
Authority
GB
United Kingdom
Prior art keywords
dimethoxy
reaction
mixture
aminoquinoline
nitroveratrole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8274/47A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
THURMOND ARTHUR WILLIAMSON
Original Assignee
THURMOND ARTHUR WILLIAMSON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by THURMOND ARTHUR WILLIAMSON filed Critical THURMOND ARTHUR WILLIAMSON
Publication of GB623789A publication Critical patent/GB623789A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

5 : 6 - Dimethoxy - 8 - aminoquinoline is prepared by adding concentrated sulphuric acid to a mixture of 4-acetamino-5-nitroveratrole, glycerin and arsenic acid at about 150 DEG C., permitting the exothermic reaction to continue for a period between 90 seconds and 15 minutes, rapidly cooling the mixture to terminate the reaction, and reducing the resulting 5 : 6 - dimethoxy - 8 - nitroquinoline with hydrogen. The reaction may be effected by heating a mixture of concentrated sulphuric acid, 4 - acetamino - 5 - nitroveratrole, glycerin and arsenic acid to a temperature of about 150 DEG C. to initiate the exothermic reaction which is allowed to continue for about 90 seconds, and the resulting 5 : 6-dimethoxy-8-nitroquinoline is reduced with stannous chloride. The initial reaction may be terminated by pouring the reaction mixture into water. Specification 351,068 is referred to.
GB8274/47A 1946-04-08 1947-03-26 Improvements in or relating to a method for producing 5:6-dimethoxy-8-aminoquinoline Expired GB623789A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US623789XA 1946-04-08 1946-04-08

Publications (1)

Publication Number Publication Date
GB623789A true GB623789A (en) 1949-05-23

Family

ID=22042089

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8274/47A Expired GB623789A (en) 1946-04-08 1947-03-26 Improvements in or relating to a method for producing 5:6-dimethoxy-8-aminoquinoline

Country Status (1)

Country Link
GB (1) GB623789A (en)

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