GB565616A - Process for the manufacture of indazolones - Google Patents

Process for the manufacture of indazolones

Info

Publication number
GB565616A
GB565616A GB924143A GB924143A GB565616A GB 565616 A GB565616 A GB 565616A GB 924143 A GB924143 A GB 924143A GB 924143 A GB924143 A GB 924143A GB 565616 A GB565616 A GB 565616A
Authority
GB
United Kingdom
Prior art keywords
cyclohexanone
added
hydrazine
ester
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB924143A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CLAUS WOLFGANG PICARD
Smith and Nephew Nominee Services Ltd
Original Assignee
CLAUS WOLFGANG PICARD
Herts Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CLAUS WOLFGANG PICARD, Herts Pharmaceuticals Ltd filed Critical CLAUS WOLFGANG PICARD
Priority to GB924143A priority Critical patent/GB565616A/en
Publication of GB565616A publication Critical patent/GB565616A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Tetrahydrindazolones for use in the production of analgesics are prepared by the reaction at a raised temperature of a cyclohexanone-o-carboxylic ester with hydrazine or phenylhydrazine formed in situ in an aqueous suspension from a salt thereof. Alkali may be added in aqueous solution to the heated mixture of hydrazine salt, water and cyclohexanone-o-carboxylic acid ester, or the cyclohexanone-o-carboxylic ester may be added to the aqueous mixture of alkali and hydrazine salt, and the temperature thereafter raised. In examples: (1) cyclohexanone-o-carboxylic acid ethyl ester is added to an aqueous solution of phenyl hydrazine sulphate, the temperature is raised to 90-100 DEG C., aqueous alkali is added and the 1-phenyltetrahydrindazolone is crystallised out; (2) cyclohexanone-o-carboxylic acid ethyl ester is added to an aqueous solution of hydrazine sulphate and caustic soda which is then heated to 90-100 DEG C.
GB924143A 1943-06-09 1943-06-09 Process for the manufacture of indazolones Expired GB565616A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB924143A GB565616A (en) 1943-06-09 1943-06-09 Process for the manufacture of indazolones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB924143A GB565616A (en) 1943-06-09 1943-06-09 Process for the manufacture of indazolones

Publications (1)

Publication Number Publication Date
GB565616A true GB565616A (en) 1944-11-17

Family

ID=9868136

Family Applications (1)

Application Number Title Priority Date Filing Date
GB924143A Expired GB565616A (en) 1943-06-09 1943-06-09 Process for the manufacture of indazolones

Country Status (1)

Country Link
GB (1) GB565616A (en)

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