GB565616A - Process for the manufacture of indazolones - Google Patents
Process for the manufacture of indazolonesInfo
- Publication number
- GB565616A GB565616A GB924143A GB924143A GB565616A GB 565616 A GB565616 A GB 565616A GB 924143 A GB924143 A GB 924143A GB 924143 A GB924143 A GB 924143A GB 565616 A GB565616 A GB 565616A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclohexanone
- added
- hydrazine
- ester
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tetrahydrindazolones for use in the production of analgesics are prepared by the reaction at a raised temperature of a cyclohexanone-o-carboxylic ester with hydrazine or phenylhydrazine formed in situ in an aqueous suspension from a salt thereof. Alkali may be added in aqueous solution to the heated mixture of hydrazine salt, water and cyclohexanone-o-carboxylic acid ester, or the cyclohexanone-o-carboxylic ester may be added to the aqueous mixture of alkali and hydrazine salt, and the temperature thereafter raised. In examples: (1) cyclohexanone-o-carboxylic acid ethyl ester is added to an aqueous solution of phenyl hydrazine sulphate, the temperature is raised to 90-100 DEG C., aqueous alkali is added and the 1-phenyltetrahydrindazolone is crystallised out; (2) cyclohexanone-o-carboxylic acid ethyl ester is added to an aqueous solution of hydrazine sulphate and caustic soda which is then heated to 90-100 DEG C.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB924143A GB565616A (en) | 1943-06-09 | 1943-06-09 | Process for the manufacture of indazolones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB924143A GB565616A (en) | 1943-06-09 | 1943-06-09 | Process for the manufacture of indazolones |
Publications (1)
Publication Number | Publication Date |
---|---|
GB565616A true GB565616A (en) | 1944-11-17 |
Family
ID=9868136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB924143A Expired GB565616A (en) | 1943-06-09 | 1943-06-09 | Process for the manufacture of indazolones |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB565616A (en) |
-
1943
- 1943-06-09 GB GB924143A patent/GB565616A/en not_active Expired
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