GB2496019B - Systems and methods for manipulating a molecule in a nanopore - Google Patents

Systems and methods for manipulating a molecule in a nanopore

Info

Publication number
GB2496019B
GB2496019B GB1216656.7A GB201216656A GB2496019B GB 2496019 B GB2496019 B GB 2496019B GB 201216656 A GB201216656 A GB 201216656A GB 2496019 B GB2496019 B GB 2496019B
Authority
GB
United Kingdom
Prior art keywords
nanopore
manipulating
molecule
systems
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1216656.7A
Other languages
English (en)
Other versions
GB2496019A (en
GB201216656D0 (en
Inventor
Roger Chen
Randy Davis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Sequencing Solutions Inc
Original Assignee
Genia Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/658,602 external-priority patent/US20120052188A1/en
Priority claimed from US12/658,591 external-priority patent/US9605307B2/en
Priority claimed from US12/658,604 external-priority patent/US8324914B2/en
Priority claimed from US12/658,601 external-priority patent/US20110192723A1/en
Priority claimed from US12/658,603 external-priority patent/US20110287414A1/en
Application filed by Genia Technologies Inc filed Critical Genia Technologies Inc
Publication of GB201216656D0 publication Critical patent/GB201216656D0/en
Publication of GB2496019A publication Critical patent/GB2496019A/en
Application granted granted Critical
Publication of GB2496019B publication Critical patent/GB2496019B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
GB1216656.7A 2010-02-08 2011-02-04 Systems and methods for manipulating a molecule in a nanopore Active GB2496019B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US12/658,602 US20120052188A1 (en) 2010-02-08 2010-02-08 Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
US12/658,591 US9605307B2 (en) 2010-02-08 2010-02-08 Systems and methods for forming a nanopore in a lipid bilayer
US12/658,604 US8324914B2 (en) 2010-02-08 2010-02-08 Systems and methods for characterizing a molecule
US12/658,601 US20110192723A1 (en) 2010-02-08 2010-02-08 Systems and methods for manipulating a molecule in a nanopore
US12/658,603 US20110287414A1 (en) 2010-02-08 2010-02-08 Systems and methods for identifying a portion of a molecule
GB201216026A GB2490847B8 (en) 2010-02-08 2011-02-04 Systems and methods for manipulating a molecule ina nanopore

Publications (3)

Publication Number Publication Date
GB201216656D0 GB201216656D0 (en) 2012-10-31
GB2496019A GB2496019A (en) 2013-05-01
GB2496019B true GB2496019B (en) 2014-11-12

Family

ID=44355716

Family Applications (2)

Application Number Title Priority Date Filing Date
GB201216026A Active GB2490847B8 (en) 2010-02-08 2011-02-04 Systems and methods for manipulating a molecule ina nanopore
GB1216656.7A Active GB2496019B (en) 2010-02-08 2011-02-04 Systems and methods for manipulating a molecule in a nanopore

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB201216026A Active GB2490847B8 (en) 2010-02-08 2011-02-04 Systems and methods for manipulating a molecule ina nanopore

Country Status (7)

Country Link
EP (2) EP2534284B1 (https=)
JP (2) JP5858931B2 (https=)
CN (2) CN103298984B (https=)
AU (1) AU2011213234B2 (https=)
CA (2) CA2995178C (https=)
GB (2) GB2490847B8 (https=)
WO (1) WO2011097028A1 (https=)

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US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
WO2012083249A2 (en) 2010-12-17 2012-06-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using modified nucleotides and nanopore detection
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US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
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CN104254619B (zh) * 2012-02-16 2018-08-24 吉尼亚科技公司 产生用于纳米孔传感器的双层的方法
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
WO2013154999A2 (en) 2012-04-09 2013-10-17 The Trustees Of Columbia University In The City Of New York Method of preparation of nanopore and uses thereof
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EP3674412A1 (en) 2012-06-20 2020-07-01 The Trustees of Columbia University in the City of New York Nucleic acid sequencing by nanopore detection of tag molecules
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US10732183B2 (en) 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
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JP6538348B2 (ja) * 2014-12-26 2019-07-03 株式会社東芝 粒子測定装置
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CN107436317A (zh) * 2017-07-21 2017-12-05 河南金泰生物技术股份有限公司 一种利用纳米通道技术检测癌症的方法
CN107377020B (zh) * 2017-08-04 2019-09-17 深圳市梅丽纳米孔科技有限公司 微流控芯片及基于微流控芯片的生物标记物的检测方法
CN107688726B (zh) * 2017-09-21 2021-09-07 深圳市易基因科技有限公司 基于液相捕获技术判定单基因病相关拷贝数缺失的方法
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CN112204154B (zh) 2018-05-28 2024-06-25 豪夫迈·罗氏有限公司 Dna-孔隙-聚合酶复合物的酶促富集
CN113260449B (zh) * 2018-12-11 2023-09-29 豪夫迈·罗氏有限公司 用于膜中自限性蛋白质孔插入的系统和方法
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US20090136958A1 (en) * 2007-10-02 2009-05-28 President And Fellows Of Harvard College Capture, recapture, and trapping of molecules with a nanopore
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WO2011067559A1 (en) * 2009-12-01 2011-06-09 Oxford Nanopore Technologies Limited Biochemical analysis instrument

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Also Published As

Publication number Publication date
JP2013519088A (ja) 2013-05-23
CA2788331A1 (en) 2011-08-11
JP6124982B2 (ja) 2017-05-10
EP2534284A1 (en) 2012-12-19
CN103298984A (zh) 2013-09-11
GB2496019A (en) 2013-05-01
AU2011213234B2 (en) 2015-05-14
GB201216656D0 (en) 2012-10-31
EP2843405B8 (en) 2023-10-04
EP2534284B1 (en) 2021-03-17
EP2534284A4 (en) 2017-01-25
WO2011097028A1 (en) 2011-08-11
EP2843405B1 (en) 2023-08-23
EP2843405A3 (en) 2015-04-29
GB2490847A8 (en) 2014-10-22
AU2011213234A2 (en) 2013-01-10
GB201216026D0 (en) 2012-10-24
GB2490847B (en) 2014-04-23
JP2016095314A (ja) 2016-05-26
GB2490847A (en) 2012-11-14
GB2490847B8 (en) 2014-10-22
CA2995178C (en) 2023-09-12
CA2995178A1 (en) 2011-08-11
CN105273991A (zh) 2016-01-27
CN103298984B (zh) 2015-11-25
EP2843405A2 (en) 2015-03-04
CN105273991B (zh) 2019-05-10
JP5858931B2 (ja) 2016-02-10
CA2788331C (en) 2018-04-03
AU2011213234A1 (en) 2012-08-23

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