CN103298984B - 用于在纳米孔中操作分子的系统和方法 - Google Patents

用于在纳米孔中操作分子的系统和方法 Download PDF

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Publication number
CN103298984B
CN103298984B CN201180016647.8A CN201180016647A CN103298984B CN 103298984 B CN103298984 B CN 103298984B CN 201180016647 A CN201180016647 A CN 201180016647A CN 103298984 B CN103298984 B CN 103298984B
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nanopore
lipid bilayer
electrical
electrical stimulation
molecule
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CN103298984A (zh
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R.陈
R.戴维斯
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F Hoffmann La Roche AG
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Genia Technologies Inc
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Priority claimed from US12/658,602 external-priority patent/US20120052188A1/en
Priority claimed from US12/658,591 external-priority patent/US9605307B2/en
Priority claimed from US12/658,604 external-priority patent/US8324914B2/en
Priority claimed from US12/658,601 external-priority patent/US20110192723A1/en
Priority claimed from US12/658,603 external-priority patent/US20110287414A1/en
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Priority to CN201510614358.8A priority Critical patent/CN105273991B/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Nanotechnology (AREA)
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CN201180016647.8A 2010-02-08 2011-02-04 用于在纳米孔中操作分子的系统和方法 Active CN103298984B (zh)

Priority Applications (1)

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CN201510614358.8A CN105273991B (zh) 2010-02-08 2011-02-04 用于在纳米孔中操作分子的系统和方法

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US12/658604 2010-02-08
US12/658,602 US20120052188A1 (en) 2010-02-08 2010-02-08 Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
US12/658601 2010-02-08
US12/658,591 US9605307B2 (en) 2010-02-08 2010-02-08 Systems and methods for forming a nanopore in a lipid bilayer
US12/658603 2010-02-08
US12/658,604 US8324914B2 (en) 2010-02-08 2010-02-08 Systems and methods for characterizing a molecule
US12/658,601 US20110192723A1 (en) 2010-02-08 2010-02-08 Systems and methods for manipulating a molecule in a nanopore
US12/658591 2010-02-08
US12/658,603 US20110287414A1 (en) 2010-02-08 2010-02-08 Systems and methods for identifying a portion of a molecule
US12/658602 2010-02-08
PCT/US2011/000205 WO2011097028A1 (en) 2010-02-08 2011-02-04 Systems and methods for manipulating a molecule in a nanopore

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CN103298984B true CN103298984B (zh) 2015-11-25

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JP (2) JP5858931B2 (https=)
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CA (2) CA2995178C (https=)
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US12252742B2 (en) 2021-09-28 2025-03-18 Axbio Inc. Methods for processing a nucleic acid sample and compositions thereof

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US12227801B2 (en) 2018-05-22 2025-02-18 Axbio Inc. Methods, systems, and compositions for nucelic acid sequencing
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JP2013519088A (ja) 2013-05-23
CA2788331A1 (en) 2011-08-11
JP6124982B2 (ja) 2017-05-10
EP2534284A1 (en) 2012-12-19
CN103298984A (zh) 2013-09-11
GB2496019A (en) 2013-05-01
AU2011213234B2 (en) 2015-05-14
GB201216656D0 (en) 2012-10-31
EP2843405B8 (en) 2023-10-04
EP2534284B1 (en) 2021-03-17
EP2534284A4 (en) 2017-01-25
WO2011097028A1 (en) 2011-08-11
EP2843405B1 (en) 2023-08-23
EP2843405A3 (en) 2015-04-29
GB2490847A8 (en) 2014-10-22
AU2011213234A2 (en) 2013-01-10
GB201216026D0 (en) 2012-10-24
GB2496019B (en) 2014-11-12
GB2490847B (en) 2014-04-23
JP2016095314A (ja) 2016-05-26
GB2490847A (en) 2012-11-14
GB2490847B8 (en) 2014-10-22
CA2995178C (en) 2023-09-12
CA2995178A1 (en) 2011-08-11
CN105273991A (zh) 2016-01-27
EP2843405A2 (en) 2015-03-04
CN105273991B (zh) 2019-05-10
JP5858931B2 (ja) 2016-02-10
CA2788331C (en) 2018-04-03
AU2011213234A1 (en) 2012-08-23

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