GB2286193A - Anticoagulants and processes for preparing such - Google Patents

Anticoagulants and processes for preparing such Download PDF

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Publication number
GB2286193A
GB2286193A GB9508157A GB9508157A GB2286193A GB 2286193 A GB2286193 A GB 2286193A GB 9508157 A GB9508157 A GB 9508157A GB 9508157 A GB9508157 A GB 9508157A GB 2286193 A GB2286193 A GB 2286193A
Authority
GB
United Kingdom
Prior art keywords
sulphated
groups
saccharide
ppm
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9508157A
Other languages
English (en)
Other versions
GB9508157D0 (en
Inventor
Klaus Jann
Barbara Jann
Benito Casu
Giangiacomo Torri
Annamaria Naggi
Giordana Grazioli
Ulf Lindahl
Helgi H Hannesson
Marion Kusche
Nahid Razi
Giorgio Zoppetti
Pasqua Oreste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Italfarmaco SpA
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV, Italfarmaco SpA filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to GB9508157A priority Critical patent/GB2286193A/en
Publication of GB9508157D0 publication Critical patent/GB9508157D0/en
Publication of GB2286193A publication Critical patent/GB2286193A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
GB9508157A 1991-03-28 1991-03-28 Anticoagulants and processes for preparing such Withdrawn GB2286193A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9508157A GB2286193A (en) 1991-03-28 1991-03-28 Anticoagulants and processes for preparing such

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9508157A GB2286193A (en) 1991-03-28 1991-03-28 Anticoagulants and processes for preparing such
GB9106757A GB2254083A (en) 1991-03-28 1991-03-28 Anticoagulants from e.coli saccharide

Publications (2)

Publication Number Publication Date
GB9508157D0 GB9508157D0 (en) 1995-06-07
GB2286193A true GB2286193A (en) 1995-08-09

Family

ID=10692438

Family Applications (2)

Application Number Title Priority Date Filing Date
GB9508157A Withdrawn GB2286193A (en) 1991-03-28 1991-03-28 Anticoagulants and processes for preparing such
GB9106757A Withdrawn GB2254083A (en) 1991-03-28 1991-03-28 Anticoagulants from e.coli saccharide

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB9106757A Withdrawn GB2254083A (en) 1991-03-28 1991-03-28 Anticoagulants from e.coli saccharide

Country Status (12)

Country Link
JP (1) JPH07501684A (xx)
AU (1) AU1430892A (xx)
CA (1) CA2107124A1 (xx)
FI (1) FI934141A0 (xx)
GB (2) GB2286193A (xx)
HU (1) HUT67208A (xx)
IE (1) IE920982A1 (xx)
IT (1) IT1254564B (xx)
PT (1) PT100316A (xx)
TW (1) TW209225B (xx)
WO (1) WO1992017507A1 (xx)
ZA (1) ZA922313B (xx)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1637158A2 (en) * 1994-09-02 2006-03-22 The Brigham And Women's Hospital, Inc. Capsular polysaccharide immunomodulator
ITMI20091445A1 (it) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione
US8008276B2 (en) 2000-12-05 2011-08-30 The Brigham And Women's Hospital, Inc. Use of zwitterionic polysaccharides for the specific modulation of immune processes
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
US9265790B2 (en) 2003-03-31 2016-02-23 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
US10772918B2 (en) 2013-05-10 2020-09-15 California Institute Of Technology Probiotic prevention and treatment of colon cancer
US10857177B2 (en) 2015-08-19 2020-12-08 President And Fellows Of Harvard College Lipidated PSA compositions and methods
US11103566B2 (en) 2010-05-20 2021-08-31 California Institute Of Technology Antigen specific Tregs and related compositions, methods and systems
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
US11419887B2 (en) 2010-04-07 2022-08-23 California Institute Of Technology Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
US11622973B2 (en) 2007-11-09 2023-04-11 California Institute Of Technology Immunomodulating compounds and related compositions and methods

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IT1270823B (it) * 1993-06-04 1997-05-13 Italfarmaco Spa Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante
IT1271057B (it) * 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
AUPO556297A0 (en) * 1997-03-11 1997-04-10 Australian National University, The Sulfated oligosaccharides having anticoagulant/ antithrombotic activity
ITMI991465A1 (it) * 1999-07-02 2001-01-02 Inalco Spa Processo per la preparazione dei polisaccaridi k4 e k5 da escherichiacoli
US20020062019A1 (en) 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20010779A1 (it) * 2001-04-12 2002-10-12 Giorgio Zoppetti Uso di polisaccaridi batterici solfati atti all'inibizione dell'angiogenesi
CN1675249A (zh) 2002-06-18 2005-09-28 格利考斯2000有限公司 N－酰基－(表)k5－胺－o－硫酸盐衍生物及其产品的制备方法
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
CN102199175A (zh) * 2011-04-07 2011-09-28 福州大学 硫酸类肝素二糖的制备纯化方法及其纯化产品

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138632A2 (fr) * 1983-07-01 1985-04-24 Choay S.A. Complexes contenant des oligosaccharides, leur préparation et leurs applications biologiques et biochimiques
US4607025A (en) * 1981-04-28 1986-08-19 Choay S.A. Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof
EP0333243A2 (en) * 1988-03-10 1989-09-20 Akzo N.V. Sulphated K5 antigen and sulphated K5 antigen fragments
EP0489647A2 (fr) * 1990-12-03 1992-06-10 Sanofi Héparosanes-N,O-sulfatés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607025A (en) * 1981-04-28 1986-08-19 Choay S.A. Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof
EP0138632A2 (fr) * 1983-07-01 1985-04-24 Choay S.A. Complexes contenant des oligosaccharides, leur préparation et leurs applications biologiques et biochimiques
EP0333243A2 (en) * 1988-03-10 1989-09-20 Akzo N.V. Sulphated K5 antigen and sulphated K5 antigen fragments
EP0489647A2 (fr) * 1990-12-03 1992-06-10 Sanofi Héparosanes-N,O-sulfatés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Kusche M, et al, Biochem. J., (United Kingdom) 1991, 275/1 pages 151-158 - see abstract *
Navia JL et al, Anal. Biochem., Nov. 1983, 135(1), pages 134-140 see abstract *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1637158A2 (en) * 1994-09-02 2006-03-22 The Brigham And Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US8008276B2 (en) 2000-12-05 2011-08-30 The Brigham And Women's Hospital, Inc. Use of zwitterionic polysaccharides for the specific modulation of immune processes
US9265790B2 (en) 2003-03-31 2016-02-23 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
US11622973B2 (en) 2007-11-09 2023-04-11 California Institute Of Technology Immunomodulating compounds and related compositions and methods
ITMI20091445A1 (it) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione
US11419887B2 (en) 2010-04-07 2022-08-23 California Institute Of Technology Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
US11103566B2 (en) 2010-05-20 2021-08-31 California Institute Of Technology Antigen specific Tregs and related compositions, methods and systems
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
US10772918B2 (en) 2013-05-10 2020-09-15 California Institute Of Technology Probiotic prevention and treatment of colon cancer
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
US10857177B2 (en) 2015-08-19 2020-12-08 President And Fellows Of Harvard College Lipidated PSA compositions and methods
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use

Also Published As

Publication number Publication date
GB9508157D0 (en) 1995-06-07
ITMI920722A1 (it) 1993-09-26
TW209225B (xx) 1993-07-11
IT1254564B (it) 1995-09-25
GB2254083A (en) 1992-09-30
WO1992017507A1 (en) 1992-10-15
FI934141A (fi) 1993-09-22
HU9302732D0 (en) 1994-01-28
PT100316A (pt) 1993-07-30
FI934141A0 (fi) 1993-09-22
CA2107124A1 (en) 1992-09-29
GB9106757D0 (en) 1991-05-15
ITMI920722A0 (it) 1992-03-26
IE920982A1 (en) 1992-10-07
HUT67208A (en) 1995-02-28
AU1430892A (en) 1992-11-02
ZA922313B (en) 1993-08-02
JPH07501684A (ja) 1995-02-23

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Legal Events

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WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)