GB2211502B - Derivatives of monophosphoryl lipid a and process for preparation - Google Patents

Derivatives of monophosphoryl lipid a and process for preparation

Info

Publication number
GB2211502B
GB2211502B GB8824330A GB8824330A GB2211502B GB 2211502 B GB2211502 B GB 2211502B GB 8824330 A GB8824330 A GB 8824330A GB 8824330 A GB8824330 A GB 8824330A GB 2211502 B GB2211502 B GB 2211502B
Authority
GB
United Kingdom
Prior art keywords
derivatives
preparation
monophosphoryl lipid
monophosphoryl
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8824330A
Other languages
English (en)
Other versions
GB8824330D0 (en
GB2211502A (en
Inventor
Kent R Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ribi Immunochem Research Inc
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of GB8824330D0 publication Critical patent/GB8824330D0/en
Publication of GB2211502A publication Critical patent/GB2211502A/en
Application granted granted Critical
Publication of GB2211502B publication Critical patent/GB2211502B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
GB8824330A 1987-10-22 1988-10-18 Derivatives of monophosphoryl lipid a and process for preparation Expired - Lifetime GB2211502B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/112,742 US4987237A (en) 1983-08-26 1987-10-22 Derivatives of monophosphoryl lipid A

Publications (3)

Publication Number Publication Date
GB8824330D0 GB8824330D0 (en) 1988-11-23
GB2211502A GB2211502A (en) 1989-07-05
GB2211502B true GB2211502B (en) 1992-02-19

Family

ID=22345625

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8824330A Expired - Lifetime GB2211502B (en) 1987-10-22 1988-10-18 Derivatives of monophosphoryl lipid a and process for preparation

Country Status (10)

Country Link
US (1) US4987237A (enExample)
JP (1) JPH075623B2 (enExample)
BE (1) BE1003250A5 (enExample)
CA (1) CA1308711C (enExample)
CH (1) CH676715A5 (enExample)
DE (1) DE3836006C2 (enExample)
FR (1) FR2622192A1 (enExample)
GB (1) GB2211502B (enExample)
IT (1) IT1230592B (enExample)
NL (1) NL8802595A (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158939A (en) * 1989-07-21 1992-10-27 Wisconsin Alumni Research Foundation Method of stimulating the immune systems of animals and compositions useful therefor
EP0482068A1 (en) * 1989-07-14 1992-04-29 American Cyanamid Company Cytokine and hormone carriers for conjugate vaccines
US5498708A (en) * 1989-07-18 1996-03-12 Montefiore Medical Center Method of synthesizing polyesters
CA2059272A1 (en) * 1990-04-12 1991-10-13 Akira Hasegawa 4,6-0-hydroxyphosphoryl-glucosamine derivatives
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
US5164375A (en) * 1991-09-27 1992-11-17 Merck & Company, Inc. Antifungal agent
US5648343A (en) * 1994-02-28 1997-07-15 The University Of Georgia Research Foundation Method for treating LPS-mediated disorders
US6218166B1 (en) 1994-12-09 2001-04-17 John Wayne Cancer Institute Adjuvant incorporation into antigen carrying cells: compositions and methods
US5681824A (en) * 1995-06-05 1997-10-28 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
US6290971B1 (en) * 1995-06-15 2001-09-18 Aventis Pasteur Limited Adjuvant compositions comprising a mineral salt and another immunostimulating compound
GB9706957D0 (en) * 1997-04-05 1997-05-21 Smithkline Beecham Plc Formulation
GB9820525D0 (en) 1998-09-21 1998-11-11 Allergy Therapeutics Ltd Formulation
GB0000891D0 (en) 2000-01-14 2000-03-08 Allergy Therapeutics Ltd Formulation
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US20030139356A1 (en) * 2001-05-18 2003-07-24 Persing David H. Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds
NZ522755A (en) 2000-05-19 2004-05-28 Corixa Corp Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds being administered in absence of exogenous antigen
US20030138769A1 (en) * 2000-08-16 2003-07-24 Birkett Ashley J. Immunogenic HBc chimer particles having enhanced stability
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US20030175863A1 (en) * 2001-08-15 2003-09-18 Birkett Ashley J. Influenza immunogen and vaccine
US20030185858A1 (en) * 2001-08-15 2003-10-02 Birkett Ashley J. Immunogenic HBc chimer particles stabilized with an N-terminal cysteine
US6911434B2 (en) * 2002-02-04 2005-06-28 Corixa Corporation Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
EP1482795B1 (en) * 2002-02-04 2009-11-11 Corixa Corporation New immunoeffector compounds
AU2003213640A1 (en) * 2002-02-28 2003-09-16 Corixa Corporation Methods of modulating dendritic cells using adjuvants
US20030224013A1 (en) * 2002-04-19 2003-12-04 Cole Garry T. Methods for protection against Coccidioides spp. infection using Coccidioides spp. urea amidohydrolase (Ure) protein
BR0312656A (pt) 2002-07-08 2005-06-07 Corixa Corp Processos para a produção de imunoefetores fosfato glicosaminìdeo de aminoalquila e dissacarìdeos e seus intermediários
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
DK1589934T3 (en) 2003-01-06 2015-12-21 Corixa Corp Certain AMINOAL COOLER GLUCOSAMINIDE PHOSPHATE COMPOUNDS AND APPLICATION
EP1449535B1 (en) * 2003-02-18 2006-05-03 Clinique La Prairie Research SA Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components
EP1835935A4 (en) * 2004-12-30 2009-06-17 Univ Rockefeller COMPOSITIONS AND METHODS FOR ENHANCING THE MATURATION AND FUNCTION OF DENDRITIC CELLS
US20060210590A1 (en) 2005-02-03 2006-09-21 Alk-Abello A/S Minor allergen control to increase safety of immunotherapy
US7622128B2 (en) * 2005-12-13 2009-11-24 University Of Washington Porphyromonas gingivalis 1435/1449 LPS as an immune modulator
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
US8273361B2 (en) 2006-09-26 2012-09-25 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
ES2539818T3 (es) 2007-08-02 2015-07-06 Biondvax Pharmaceuticals Ltd. Vacunas contra la gripe multiepitópicas multiméricas
US20090215710A1 (en) * 2007-09-24 2009-08-27 Reliance Life Sciences Pvt. Ltd. Carbohydrate based toll-like receptor (tlr) antagonists
US20090215908A1 (en) * 2007-09-24 2009-08-27 Reliance Life Sciences Pvt. Ltd. Toll like receptor (tlr) signaling antagonist
CA2744739A1 (en) 2007-12-03 2009-06-11 President And Fellows Of Harvard College Chlamydia antigens
LT2437753T (lt) 2009-06-05 2016-12-12 Infectious Disease Research Institute Sintetiniai gliukopiranozillipidų adjuvantai ir juos turinčios vakcinų kompozicijos
WO2012114323A1 (en) 2011-02-22 2012-08-30 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
WO2012141984A1 (en) 2011-04-08 2012-10-18 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
GB201106802D0 (en) 2011-04-21 2011-06-01 Allergy Therapeutics Ltd Process for preparing vaccine composition
LT2850431T (lt) 2012-05-16 2018-06-25 Immune Design Corp. Vakcinos, skirtos hsv-2
WO2014124228A1 (en) 2013-02-07 2014-08-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
DK2958935T3 (da) 2013-02-20 2019-09-16 Bergen Teknologioverforing As Vaccine
KR102039520B1 (ko) 2013-04-18 2019-11-01 이뮨 디자인 코포레이션 암 치료에 이용하기 위한 gla 단일요법
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
ES3020582T3 (en) 2013-07-26 2025-05-23 Inst Nat Sante Rech Med Methods and pharmaceutical compositions for the treatment of bacterial infections
WO2016180852A1 (en) 2015-05-12 2016-11-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preparing antigen-specific t cells from an umbilical cord blood sample
BR112020004747A2 (pt) 2017-09-13 2020-09-24 Sanofi Pasteur composição imunogênica de citomegalovírus humano
TW201946650A (zh) 2018-03-12 2019-12-16 美商詹森藥物公司 針對腹內感染之疫苗
EP3841111A1 (en) 2018-08-24 2021-06-30 Vestlandets Innovasjonsselskap AS Heat-stable enterotoxins mutants as antidiarrheal vaccine antigens
AU2020358862A1 (en) 2019-10-02 2022-04-14 Janssen Vaccines & Prevention B.V. Staphylococcus peptides and methods of use
WO2021144369A1 (en) 2020-01-16 2021-07-22 Janssen Pharmaceuticals, Inc. Fimh mutant, compositions therewith and use thereof
TW202241929A (zh) 2021-01-12 2022-11-01 美商詹森藥物公司 ＦｉｍＨ突變體、其組成物及其用途
CA3215752A1 (en) 2021-04-01 2022-10-06 Janssen Pharmaceuticals, Inc. Production of e. coli o18 bioconjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0414725Y2 (enExample) * 1980-09-30 1992-04-02
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
JPS62129293A (ja) * 1985-11-28 1987-06-11 Toho Yakuhin Kogyo Kk 親水性のリピドａ単糖類縁体
JPS62195396A (ja) * 1986-02-20 1987-08-28 Toho Yakuhin Kogyo Kk 親水性及び疎水性の基を置換したりピドａ単糖類縁体

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Bact. Endotoxin" J.Y. Hamma (ed.) (Verlag Chemie, Weinheim,Germany: 1984) pp. 61-100 *
ACS Sym. Ser. 231 (Bact. Liposaccharides) 237-54 (1983) *
Infect. Immun. 44(2) 421-33 (1984) *
JP 59048497 *
Recl. J. R. Neth. Chem. Soc. 102(10) 438-49 (1983) *
Tetrahedron Letters 24(19) 2011-4 (1983) *

Also Published As

Publication number Publication date
JPH075623B2 (ja) 1995-01-25
DE3836006A1 (de) 1989-05-03
IT8822399A0 (it) 1988-10-21
IT1230592B (it) 1991-10-28
BE1003250A5 (fr) 1992-02-11
JPH075623B1 (enExample) 1995-01-25
CA1308711C (en) 1992-10-13
DE3836006C2 (de) 1996-07-11
US4987237A (en) 1991-01-22
CH676715A5 (enExample) 1991-02-28
GB8824330D0 (en) 1988-11-23
FR2622192B1 (enExample) 1994-11-10
FR2622192A1 (fr) 1989-04-28
GB2211502A (en) 1989-07-05
JPH01146891A (ja) 1989-06-08
NL8802595A (nl) 1989-05-16

Similar Documents

Publication Publication Date Title
GB2211502B (en) Derivatives of monophosphoryl lipid a and process for preparation
GR880100512A (en) Preparation method of 4-ammonium derivatives of epipodophyllotoxinc glucosite
YU20288A (en) Process for preparing derivatives of adenosyn 5-carboxamides
HU896774D0 (en) Process for preparation of condensated-quinoline-derivatives
HU896728D0 (en) Process for preparation of mono-n-alkylated polyzamacrocyclides
YU16688A (en) Process for obtaining derivatives of benzoyl-urea
IL85706A0 (en) Process for the preparation of nitroethene derivatives
CS708787A1 (en) Method of 5-azacytosines preparation
EG18591A (en) Process for preparing of azolidinedione derivatives
EP0312922A3 (en) Oxethylsulfonyl-nitro- or -amino-benzoic acids and process for their preparation
GR880100265A (en) Preparation process of quinolinothioether
HU900159D0 (en) Process for preparation of tetrazide-derivatives
YU86189A (en) Process for obtaining derivatives of benzoilurea
HU900888D0 (en) Process for preparation of 1-arylsulfonyl-pyrrolidin-2-thion and 1-arylsulfonyl-piperidin-2-thion derivatives
GB8720773D0 (en) Preparation of derivatives
ZA881990B (en) Dicyanoethylaryl derivatives and process for their preparation
CS435387A1 (en) Method of 3-phenylalkanales preparation
GB8822146D0 (en) Process for preparation of n-aralkylated aminofluoranes
YU193687A (en) Process for preparing derivatives of l-aspartyl-l-phenylalanyn
YU163187A (en) Process for preparing derivatives of 10-dihydro-10-deoxo-11-azaeritronolides
BG43254A1 (en) Derivatives of 1- benzhydrylpiperazine and method for their preparation
BG43923A1 (en) Derivatives of n- substituted- 2- oxazolidones and method for their preparation
GB8822386D0 (en) Process for preparation of cyclopentene derivatives
CS59588A2 (en) Method of oxetanocine derivative preparation
CS340888A2 (en) Method of oxetanocine derivative preparation

Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20081017