GB2091719B - Benzofuran derivatives - Google Patents

Benzofuran derivatives

Info

Publication number
GB2091719B
GB2091719B GB8107130A GB8107130A GB2091719B GB 2091719 B GB2091719 B GB 2091719B GB 8107130 A GB8107130 A GB 8107130A GB 8107130 A GB8107130 A GB 8107130A GB 2091719 B GB2091719 B GB 2091719B
Authority
GB
United Kingdom
Prior art keywords
benzofuran derivatives
benzofuran
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8107130A
Other languages
English (en)
Other versions
GB2091719A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Menarini SAS
Original Assignee
A Menarini SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Menarini SAS filed Critical A Menarini SAS
Publication of GB2091719A publication Critical patent/GB2091719A/en
Application granted granted Critical
Publication of GB2091719B publication Critical patent/GB2091719B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8107130A 1980-11-12 1981-03-06 Benzofuran derivatives Expired GB2091719B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT09583/80A IT1154888B (it) 1980-11-12 1980-11-12 Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione

Publications (2)

Publication Number Publication Date
GB2091719A GB2091719A (en) 1982-08-04
GB2091719B true GB2091719B (en) 1985-06-05

Family

ID=11132470

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8107130A Expired GB2091719B (en) 1980-11-12 1981-03-06 Benzofuran derivatives

Country Status (14)

Country Link
US (2) US4485112A (enEXAMPLES)
JP (1) JPS57109774A (enEXAMPLES)
BE (1) BE891092A (enEXAMPLES)
CA (1) CA1182454A (enEXAMPLES)
CH (1) CH653679A5 (enEXAMPLES)
DE (1) DE3145004A1 (enEXAMPLES)
DK (1) DK153788C (enEXAMPLES)
ES (1) ES8307781A1 (enEXAMPLES)
FR (1) FR2493845B1 (enEXAMPLES)
GB (1) GB2091719B (enEXAMPLES)
GR (1) GR76933B (enEXAMPLES)
IT (1) IT1154888B (enEXAMPLES)
NL (1) NL8105121A (enEXAMPLES)
SE (1) SE451328B (enEXAMPLES)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550091B1 (fr) * 1983-08-02 1986-05-23 Sanofi Sa Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne
CA1281325C (en) * 1984-06-20 1991-03-12 Patrice C. Belanger Benzofuran derivatives
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
IT1216256B (it) * 1986-08-13 1990-02-22 Menarini Sas (benzofuran-2-il) imidazoli, con attivita' farmacologica,loro sali e procedimenti di fabbricazione relativi.
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4806663A (en) * 1987-04-06 1989-02-21 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
AU2543388A (en) * 1987-09-30 1989-04-18 University Of Tennessee Research Corporation, The Certain 3-substituted 2-alkyl benzothiophene derivatives
US4831156A (en) * 1987-09-30 1989-05-16 The University Of Tennessee Research Corp. 3-substituted 2-alkyl indole derivatives
US4975458A (en) * 1989-03-13 1990-12-04 Taro Pharmaceuticals Industries, Ltd. 2-alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
EP0601181A4 (en) * 1991-07-09 1994-07-27 Nippon Shinyaku Co Ltd Benzofuran derivative and pharmaceutical composition.
FR2708609B1 (fr) * 1993-07-29 1995-10-20 Sanofi Elf Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant.
US6653328B1 (en) * 1995-03-10 2003-11-25 Eli Lilly And Company 3-benzyl-benzothiophenes
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
US6417199B1 (en) * 1995-03-10 2002-07-09 Eli Lilly And Company 3-benzyl-benzothiophenes
WO2004026253A2 (en) * 2002-09-17 2004-04-01 Arqule, Inc. Novel lapacho compounds and methods of use thereof
EP2447263A1 (en) * 2010-09-27 2012-05-02 Bioprojet Benzazole derivatives as histamine H4 receptor ligands
US20210130312A1 (en) * 2018-04-03 2021-05-06 Children's Hospital Medical Center Inhibitors of eya3-protein tyrosine phosphatase in dna damage repair signaling of pulmonary arterial hypertension

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3156688A (en) * 1962-11-05 1964-11-10 Abbott Lab Nu-alkyl and nu-aralkyl benzoxacycloalkanemethylamines
DE1492403A1 (de) * 1965-03-30 1969-12-04 Merck Ag E UV-Lichtschutzmittel fuer kosmetische Zwecke
GB1160925A (en) * 1967-02-08 1969-08-06 Menarini Sas 2-Substituted Benzofuran Derivatives
US3880891A (en) * 1973-09-21 1975-04-29 Smithkline Corp Substituted benzofurans
US4024273A (en) * 1974-06-20 1977-05-17 Smithkline Corporation Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes

Also Published As

Publication number Publication date
CH653679A5 (it) 1986-01-15
BE891092A (fr) 1982-03-01
DK153788B (da) 1988-09-05
NL8105121A (nl) 1982-06-01
IT1154888B (it) 1987-01-21
JPH0245629B2 (enEXAMPLES) 1990-10-11
US4604392A (en) 1986-08-05
US4485112A (en) 1984-11-27
DK153788C (da) 1989-01-23
ES507072A0 (es) 1983-08-16
JPS57109774A (en) 1982-07-08
IT8009583A0 (it) 1980-11-12
SE8106733L (sv) 1982-05-13
FR2493845B1 (fr) 1985-07-05
SE451328B (sv) 1987-09-28
GB2091719A (en) 1982-08-04
FR2493845A1 (fr) 1982-05-14
CA1182454A (en) 1985-02-12
DE3145004A1 (de) 1982-06-16
ES8307781A1 (es) 1983-08-16
DK501181A (da) 1982-05-13
GR76933B (enEXAMPLES) 1984-09-04

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee