GB2084573B - Improvements in or relating to 3-aryl-5-isothiazole derivatives - Google Patents

Improvements in or relating to 3-aryl-5-isothiazole derivatives

Info

Publication number
GB2084573B
GB2084573B GB8128465A GB8128465A GB2084573B GB 2084573 B GB2084573 B GB 2084573B GB 8128465 A GB8128465 A GB 8128465A GB 8128465 A GB8128465 A GB 8128465A GB 2084573 B GB2084573 B GB 2084573B
Authority
GB
United Kingdom
Prior art keywords
aryl
relating
isothiazole derivatives
isothiazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8128465A
Other languages
English (en)
Other versions
GB2084573A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB2084573A publication Critical patent/GB2084573A/en
Application granted granted Critical
Publication of GB2084573B publication Critical patent/GB2084573B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB8128465A 1980-09-22 1981-09-21 Improvements in or relating to 3-aryl-5-isothiazole derivatives Expired GB2084573B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/189,435 US4346094A (en) 1980-09-22 1980-09-22 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels

Publications (2)

Publication Number Publication Date
GB2084573A GB2084573A (en) 1982-04-15
GB2084573B true GB2084573B (en) 1984-09-12

Family

ID=22697314

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8128465A Expired GB2084573B (en) 1980-09-22 1981-09-21 Improvements in or relating to 3-aryl-5-isothiazole derivatives

Country Status (22)

Country Link
US (1) US4346094A (enExample)
EP (1) EP0048615B1 (enExample)
JP (1) JPS5785379A (enExample)
KR (1) KR830007597A (enExample)
AR (1) AR229103A1 (enExample)
AT (1) ATE7657T1 (enExample)
AU (1) AU7551681A (enExample)
CS (1) CS228536B2 (enExample)
DD (1) DD201790A5 (enExample)
DE (1) DE3163900D1 (enExample)
DK (1) DK417981A (enExample)
ES (1) ES8301225A1 (enExample)
FI (1) FI812940L (enExample)
GB (1) GB2084573B (enExample)
GR (1) GR75046B (enExample)
IL (1) IL63890A0 (enExample)
NO (1) NO813208L (enExample)
PL (1) PL130497B1 (enExample)
PT (1) PT73711B (enExample)
RO (1) RO82216A (enExample)
YU (1) YU227181A (enExample)
ZA (1) ZA816549B (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428956A (en) 1980-12-29 1984-01-31 Merck & Co., Inc. 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4431652A (en) * 1980-12-29 1984-02-14 Merck & Co., Inc. 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis
US4539328A (en) * 1983-03-25 1985-09-03 Fmc Corporation Nematicidal isothiazole derivatives
US4620865A (en) * 1983-11-07 1986-11-04 Eli Lilly And Company Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
ZW21687A1 (en) * 1986-12-12 1988-07-20 Hoffmann La Roche Triazine derivatives
JP2725886B2 (ja) * 1990-11-30 1998-03-11 帝人株式会社 ２―アリールチアゾール誘導体及びその医薬組成物
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
MY117352A (en) * 1995-10-31 2004-06-30 Ciba Sc Holding Ag Oximesulfonic acid esters and the use thereof as latent sulfonic acids.
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
EP1044002A4 (en) 1997-11-07 2003-05-02 Univ Johns Hopkins METHODS FOR THE TREATMENT OF HEART CONTRACTILITY
TW575792B (en) * 1998-08-19 2004-02-11 Ciba Sc Holding Ag New unsaturated oxime derivatives and the use thereof as latent acids
SG78412A1 (en) 1999-03-31 2001-02-20 Ciba Sc Holding Ag Oxime derivatives and the use thereof as latent acids
CA2474532A1 (en) 2002-02-06 2003-08-14 Peter Murer Sulfonate derivatives and the use therof as latent acids
EP1783116B1 (en) * 2004-08-27 2009-08-26 Astellas Pharma Inc. 2-phenylpyridine derivative
JPWO2006022375A1 (ja) * 2004-08-27 2008-05-08 アステラス製薬株式会社 ２−フェニルチオフェン誘導体
WO2007043457A1 (ja) 2005-10-07 2007-04-19 Astellas Pharma Inc. トリアリールカルボン酸誘導体
MX2008010646A (es) 2006-02-24 2008-10-14 Astellas Pharma Inc Agente para tratar o prevenir ulcera digestiva.
GB2450975B (en) 2007-07-12 2010-02-24 Ciba Holding Inc Yellow radiation curing inks
EP2668953A1 (en) * 2008-05-22 2013-12-04 Bristol-Myers Squibb Company Pharmaceutical compositions comprising an SGLT2 inhibitor with a supply of carbohydrate and/or an inhibitor of uric acid synthesis
PL2404908T3 (pl) 2009-02-27 2014-12-31 Teijin Ltd Sposób wytwarzania podstawionej fenylem pochodnej heterocyklicznej przez sprzężenie z użyciem katalizatora metalu przejściowego
JP2012522084A (ja) 2009-03-30 2012-09-20 ビーエーエスエフ ソシエタス・ヨーロピア Ｕｖ線量インジケータフィルム
RU2563459C2 (ru) 2010-08-27 2015-09-20 Тейдзин Фарма Лимитед Способ получения фенилзамещенного гетероциклического производного посредством способа сочетания с использованием соединения палладия
US9310677B2 (en) 2011-01-28 2016-04-12 Basf Polymerizable composition comprising an oxime sulfonate as thermal curing agent
RU2632884C2 (ru) * 2013-03-29 2017-10-11 Тейдзин Фарма Лимитед Производное пиразола
WO2016030790A1 (en) 2014-08-29 2016-03-03 Basf Se Oxime sulfonate derivatives
MX375374B (es) 2015-04-29 2025-03-06 Bsn Medical Gmbh Dispositivo de baño médico.
CA2984044A1 (en) 2015-04-29 2016-11-03 Bsn Medical Gmbh Steady-state no production via ph control

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178604A (en) * 1966-03-21 1970-01-21 American Cyanamid Co Novel Pyridinium Salts and Methods for Preparing Same
US3464999A (en) * 1967-07-27 1969-09-02 R & L Molecular Research Ltd Thiadiazolylisothiazoles
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
GB1192701A (en) * 1968-03-22 1970-05-20 Ici Ltd Novel Thiazole Derivatives, the preparation thereof and Compositions containing the same
US3681498A (en) * 1970-10-19 1972-08-01 American Cyanamid Co Isothiazolyl pyridinium salts as hypoglycemic agents

Also Published As

Publication number Publication date
KR830007597A (ko) 1983-11-04
DD201790A5 (de) 1983-08-10
IL63890A0 (en) 1981-12-31
NO813208L (no) 1982-03-23
EP0048615A1 (en) 1982-03-31
PT73711B (en) 1982-12-20
ZA816549B (en) 1983-04-27
PT73711A (en) 1981-10-01
AR229103A1 (es) 1983-06-15
PL130497B1 (en) 1984-08-31
FI812940A7 (fi) 1982-03-23
YU227181A (en) 1983-10-31
AU7551681A (en) 1982-04-01
GR75046B (enExample) 1984-07-12
ATE7657T1 (de) 1984-06-15
RO82216B (ro) 1983-06-30
US4346094A (en) 1982-08-24
ES505678A0 (es) 1982-12-01
JPS5785379A (en) 1982-05-28
PL233103A1 (enExample) 1982-12-20
EP0048615B1 (en) 1984-05-30
CS228536B2 (en) 1984-05-14
DK417981A (da) 1982-03-23
GB2084573A (en) 1982-04-15
DE3163900D1 (en) 1984-07-05
ES8301225A1 (es) 1982-12-01
FI812940L (fi) 1982-03-23
RO82216A (ro) 1983-07-07

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Legal Events

Date Code Title Description
7732 Case decided by the comptroller ** patent revoked (sect. 73(2)/1977)