GB201610748D0 - Improved diffrentation method - Google Patents

Improved diffrentation method

Info

Publication number
GB201610748D0
GB201610748D0 GBGB1610748.4A GB201610748A GB201610748D0 GB 201610748 D0 GB201610748 D0 GB 201610748D0 GB 201610748 A GB201610748 A GB 201610748A GB 201610748 D0 GB201610748 D0 GB 201610748D0
Authority
GB
United Kingdom
Prior art keywords
diffrentation
improved
improved diffrentation
diffrentation method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1610748.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Nederlandse Akademie van Wetenschappen
Original Assignee
Koninklijke Nederlandse Akademie van Wetenschappen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Nederlandse Akademie van Wetenschappen filed Critical Koninklijke Nederlandse Akademie van Wetenschappen
Priority to GBGB1610748.4A priority Critical patent/GB201610748D0/en
Publication of GB201610748D0 publication Critical patent/GB201610748D0/en
Priority to KR1020197001809A priority patent/KR102478617B1/ko
Priority to CN201780047555.3A priority patent/CN109844098A/zh
Priority to JP2019518148A priority patent/JP7525263B2/ja
Priority to RU2018145539A priority patent/RU2772435C2/ru
Priority to BR112018076554-6A priority patent/BR112018076554A2/pt
Priority to CA3030098A priority patent/CA3030098A1/en
Priority to MX2018016258A priority patent/MX2018016258A/es
Priority to PCT/EP2017/065101 priority patent/WO2017220586A1/en
Priority to EP17732860.6A priority patent/EP3472302A1/en
Priority to AU2017281406A priority patent/AU2017281406B2/en
Priority to SG11201811405QA priority patent/SG11201811405QA/en
Priority to US16/310,933 priority patent/US20210047618A1/en
Priority to KR1020227043758A priority patent/KR20230004913A/ko
Priority to MX2025004237A priority patent/MX2025004237A/es
Priority to IL263854A priority patent/IL263854A/en
Priority to JP2022024460A priority patent/JP2022068302A/ja
Priority to US18/918,172 priority patent/US20250145963A1/en
Ceased legal-status Critical Current

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0679—Cells of the gastro-intestinal tract
    • C12N5/068—Stem cells; Progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0679—Cells of the gastro-intestinal tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
GBGB1610748.4A 2016-06-20 2016-06-20 Improved diffrentation method Ceased GB201610748D0 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GBGB1610748.4A GB201610748D0 (en) 2016-06-20 2016-06-20 Improved diffrentation method
KR1020227043758A KR20230004913A (ko) 2016-06-20 2017-06-20 개선된 분화 방법
PCT/EP2017/065101 WO2017220586A1 (en) 2016-06-20 2017-06-20 Improved differentiation method
AU2017281406A AU2017281406B2 (en) 2016-06-20 2017-06-20 Improved differentiation method
JP2019518148A JP7525263B2 (ja) 2016-06-20 2017-06-20 改善された分化方法
RU2018145539A RU2772435C2 (ru) 2016-06-20 2017-06-20 Улучшенный способ дифференцировки
BR112018076554-6A BR112018076554A2 (pt) 2016-06-20 2017-06-20 método para diferenciar células progenitoras, para cultivar células-tronco epiteliais, para triagem de um fármaco ou cosmético terapêutico ou profilático, para induzir a quiescência das células-tronco lgr5+ e para obtenção de uma população de células enriquecida em eecs, meio de diferenciação, organoide, composição, uso de um organoide ou uma célula derivada, formulação farmacêutica, população de células-tronco quiescentes, inibidor da bmp, e, ativador da bmp.
CA3030098A CA3030098A1 (en) 2016-06-20 2017-06-20 Improved differentiation method
MX2018016258A MX2018016258A (es) 2016-06-20 2017-06-20 Metodo de diferenciacion mejorada.
KR1020197001809A KR102478617B1 (ko) 2016-06-20 2017-06-20 개선된 분화 방법
EP17732860.6A EP3472302A1 (en) 2016-06-20 2017-06-20 Improved differentiation method
CN201780047555.3A CN109844098A (zh) 2016-06-20 2017-06-20 改进的分化方法
SG11201811405QA SG11201811405QA (en) 2016-06-20 2017-06-20 Improved differentiation method
US16/310,933 US20210047618A1 (en) 2016-06-20 2017-06-20 Improved Differentiation Method
MX2025004237A MX2025004237A (es) 2016-06-20 2018-12-19 Metodo de diferenciacion mejorada
IL263854A IL263854A (en) 2016-06-20 2018-12-20 Improved methods of differentiation
JP2022024460A JP2022068302A (ja) 2016-06-20 2022-02-21 改善された分化方法
US18/918,172 US20250145963A1 (en) 2016-06-20 2024-10-17 Improved Differentiation Method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1610748.4A GB201610748D0 (en) 2016-06-20 2016-06-20 Improved diffrentation method

Publications (1)

Publication Number Publication Date
GB201610748D0 true GB201610748D0 (en) 2016-08-03

Family

ID=56895200

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1610748.4A Ceased GB201610748D0 (en) 2016-06-20 2016-06-20 Improved diffrentation method

Country Status (13)

Country Link
US (2) US20210047618A1 (enExample)
EP (1) EP3472302A1 (enExample)
JP (2) JP7525263B2 (enExample)
KR (2) KR102478617B1 (enExample)
CN (1) CN109844098A (enExample)
AU (1) AU2017281406B2 (enExample)
BR (1) BR112018076554A2 (enExample)
CA (1) CA3030098A1 (enExample)
GB (1) GB201610748D0 (enExample)
IL (1) IL263854A (enExample)
MX (2) MX2018016258A (enExample)
SG (1) SG11201811405QA (enExample)
WO (1) WO2017220586A1 (enExample)

Families Citing this family (54)

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KR102558606B1 (ko) 2016-12-05 2023-07-26 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
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JP7506657B2 (ja) 2018-07-26 2024-06-26 チルドレンズ ホスピタル メディカル センター 肝胆膵組織およびその作製方法
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KR102133693B1 (ko) * 2018-12-28 2020-07-13 서울대학교병원 타액선 유래 줄기세포를 타액선 조직으로 분화시키는 방법 및 구강 건조증 치료 또는 예방용 조성물
CN111500525B (zh) * 2019-01-30 2023-05-02 中国科学院广州生物医药与健康研究院 一种组合物及其应用
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