SG11201811405QA - Improved differentiation method - Google Patents
Improved differentiation methodInfo
- Publication number
- SG11201811405QA SG11201811405QA SG11201811405QA SG11201811405QA SG11201811405QA SG 11201811405Q A SG11201811405Q A SG 11201811405QA SG 11201811405Q A SG11201811405Q A SG 11201811405QA SG 11201811405Q A SG11201811405Q A SG 11201811405QA SG 11201811405Q A SG11201811405Q A SG 11201811405QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- methods
- uppsalalaan
- utrecht
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0679—Cells of the gastro-intestinal tract
- C12N5/068—Stem cells; Progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/220586 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) (74) International Patent Classification: (81) C12N 5/071 (2010.01) A61K 31/4427 (2006.01) International Application Number: PCT/EP2017/065101 International Filing Date: 20 June 2017 (20.06.2017) English Publication Language: English Priority Data: 1610748.4 20 June 2016 (20.06.2016) GB (84) Applicant: KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN [NL/NL]; c/o Hubrecht Institute, Uppsalalaan 8, 3584 Utrecht (NL). Inventors: CLEVERS, Johannes Carolus; Hubrecht In- stitute, Uppsalalaan 8, 3584 Utrecht (NL). BEUMER, Joep; Hubrecht Institute, Uppsalalaan 8, 3584 Utrecht (NL). Agent: GOODFELLOW, Hugh Robin et al.; Carpmaels & Ransford LLP, One Southampton Row, London WC1B 5HA (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — = = (54) (57) Title: IMPROVED DIFFERENTIATION R , , . E F t , So, V METHOD FIG. EGFRI „., D EGFR . 5A .3,7. fr , I 1 ; I ' ,2 - , . \"S. FRi rtl e, and = = = = = = = = = = = = = = 11 .4 GC kr) 0 ei ei IN 0 to N in enteroendocrine cells and medical uses relating to such methods. CHUALYZ uses of the cells and organoids obtained by said methods. The invention also relates to methods for modulating hormone expression : The invention relates to methods and media for differentiating cells, for example for obtaining enteroendocrine cells, C [Continued on next page] WO 2017/220586 Al MIDEDIM01101 DIDIRMEMEE11OI0111111011111111101111111111111111111 Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1610748.4A GB201610748D0 (en) | 2016-06-20 | 2016-06-20 | Improved diffrentation method |
PCT/EP2017/065101 WO2017220586A1 (en) | 2016-06-20 | 2017-06-20 | Improved differentiation method |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201811405QA true SG11201811405QA (en) | 2019-01-30 |
Family
ID=56895200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811405QA SG11201811405QA (en) | 2016-06-20 | 2017-06-20 | Improved differentiation method |
Country Status (13)
Country | Link |
---|---|
US (1) | US20210047618A1 (en) |
EP (1) | EP3472302A1 (en) |
JP (2) | JP7525263B2 (en) |
KR (2) | KR102478617B1 (en) |
CN (1) | CN109844098A (en) |
AU (1) | AU2017281406B2 (en) |
BR (1) | BR112018076554A2 (en) |
CA (1) | CA3030098A1 (en) |
GB (1) | GB201610748D0 (en) |
IL (1) | IL263854A (en) |
MX (1) | MX2018016258A (en) |
SG (1) | SG11201811405QA (en) |
WO (1) | WO2017220586A1 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
WO2013093812A2 (en) | 2011-12-19 | 2013-06-27 | Umc Utrecht Holding B.V. | A rapid quantitative assay to measure cftr function in a primary intestinal culture model |
US10597633B2 (en) | 2014-05-16 | 2020-03-24 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture method for organoids |
CN113249297A (en) | 2014-05-28 | 2021-08-13 | 儿童医院医疗中心 | Methods and systems for converting precursor cells to stomach tissue via directed differentiation |
US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
GB201603569D0 (en) | 2016-03-01 | 2016-04-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved differentiation method |
EP3452578B1 (en) | 2016-05-05 | 2022-08-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
NZ753873A (en) | 2016-12-05 | 2023-01-27 | Children’S Hospital Medical Center | Colonic organoids and methods of making and using same |
CN110317775B (en) * | 2018-03-30 | 2022-06-10 | 中国科学院分子细胞科学卓越创新中心 | Culture medium for hepatocyte culture and liver organoid preparation |
WO2019217493A2 (en) * | 2018-05-07 | 2019-11-14 | President And Fellows Of Harvard College | Cell populations and gene expression associated with in vitro beta cell differentiation |
JP7377486B2 (en) * | 2018-09-10 | 2023-11-10 | 国立大学法人東京工業大学 | Method for producing intestinal cells from pluripotent stem cells |
KR20200065892A (en) | 2018-11-30 | 2020-06-09 | 오가노이드사이언스 주식회사 | A composition for bio transplanting of organoid |
KR102133693B1 (en) * | 2018-12-28 | 2020-07-13 | 서울대학교병원 | Method for differentiating salivary gland stem cell to salivary gland tissue and pharmaceutical composition for treating or preventing xerostomia |
CN111500525B (en) * | 2019-01-30 | 2023-05-02 | 中国科学院广州生物医药与健康研究院 | Composition and application thereof |
ES2961154T3 (en) * | 2019-02-19 | 2024-03-08 | Miltenyi Biotec Bv & Co Kg | Cell culture medium and method for the generation of epithelial organoids from epithelial stem cells |
CN113423818A (en) * | 2019-02-26 | 2021-09-21 | 北京大学 | Compositions and methods for long term culture of hepatocytes |
GB201906978D0 (en) | 2019-05-17 | 2019-07-03 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method using integrin agonist |
WO2021055565A1 (en) * | 2019-09-17 | 2021-03-25 | The Trustees Of Indiana University | Prolonged function of liver organoids as an in vitro model for the study of liver disease |
US11629385B2 (en) | 2019-11-22 | 2023-04-18 | Tempus Labs, Inc. | Tumor organoid culture compositions, systems, and methods |
KR102232244B1 (en) * | 2019-11-29 | 2021-03-24 | 고려대학교 산학협력단 | A composition for enhancing efficiency of reprogramming of somatic cells into induced pluripotent stem cells comprising MHY1485 or a derivative thereof and method for enhancing efficiency of reprogramming using the same |
WO2021113821A1 (en) | 2019-12-05 | 2021-06-10 | Tempus Labs, Inc. | Systems and methods for high throughput drug screening |
AU2020399785A1 (en) * | 2019-12-12 | 2022-06-30 | The Walter And Eliza Hall Institute Of Medical Research | Organoid cultures |
GB202004706D0 (en) | 2020-03-31 | 2020-05-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Methods and tools for studying enteroendocrine cells |
US11561178B2 (en) | 2020-04-20 | 2023-01-24 | Tempus Labs, Inc. | Artificial fluorescent image systems and methods |
WO2021254296A1 (en) * | 2020-06-14 | 2021-12-23 | 浙江大学 | Bioactive substance composition, serum-free culture medium comprising the composition, and uses thereof |
US20220135950A1 (en) * | 2020-11-03 | 2022-05-05 | Korea Research Institute Of Bioscience And Biotechnology | Human intestinal epithelium model and method for preparing same |
CN113151152A (en) * | 2021-05-11 | 2021-07-23 | 中国人民解放军军事科学院军事医学研究院 | Culture method of mouse lung organoid and special culture solution thereof |
WO2022241303A1 (en) * | 2021-05-14 | 2022-11-17 | University Of South Florida | Composition and method for treating covid-19 |
CN113073080B (en) * | 2021-06-03 | 2021-08-13 | 北京科途医学科技有限公司 | Polymorphic rhabdomyosarcoma organoid and culture method, culture medium and application thereof |
CN113403277B (en) * | 2021-06-28 | 2023-05-16 | 山东省第二人民医院(山东省耳鼻喉医院、山东省耳鼻喉研究所) | Method for separating FZD10 positive glial cells of inner ear |
GB202109913D0 (en) * | 2021-07-09 | 2021-08-25 | Stichting Hubrecht Organoid Tech | Organoid-derived monolayers and uses thereof |
JPWO2023074648A1 (en) * | 2021-10-25 | 2023-05-04 | ||
EP4423252A1 (en) * | 2021-10-29 | 2024-09-04 | Trailhead Biosystems Inc. | Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons |
KR20240088578A (en) * | 2022-11-24 | 2024-06-20 | 한국생명공학연구원 | Xenogenic-free culture of intestinal stem cell on the thin film-coated surfaces |
CN116478912A (en) | 2023-06-07 | 2023-07-25 | 合肥工业大学 | Culture medium for inducing directional differentiation of intestinal organoids of mice into enteroendocrine cells and application of culture medium |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5458112B2 (en) * | 2009-02-03 | 2014-04-02 | コーニンクレッカ ネザーランド アカデミー ヴァン ウェテンシャッペン | Culture medium for epithelial stem cells and organoids containing the stem cells |
EP2772534B1 (en) * | 2011-10-27 | 2019-09-18 | National University Corporation Tokyo Medical and Dental University | Culturing colorectal epithelial stem cells and transplanting colorectal epithelium |
SG11201506520TA (en) * | 2013-02-18 | 2015-09-29 | Univ Health Network | Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells |
PT2970890T (en) * | 2013-03-14 | 2020-04-24 | Massachusetts Inst Technology | Compositions and methods for epithelial stem cell expansion and culture |
EP3160503B1 (en) | 2014-06-26 | 2021-02-17 | The Trustees of Columbia University in the City of New York | Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells |
JP2019506153A (en) | 2016-01-08 | 2019-03-07 | マサチューセッツ インスティテュート オブ テクノロジー | Production of differentiated enteroendocrine cells and insulin-producing cells |
-
2016
- 2016-06-20 GB GBGB1610748.4A patent/GB201610748D0/en not_active Ceased
-
2017
- 2017-06-20 AU AU2017281406A patent/AU2017281406B2/en active Active
- 2017-06-20 SG SG11201811405QA patent/SG11201811405QA/en unknown
- 2017-06-20 CA CA3030098A patent/CA3030098A1/en active Pending
- 2017-06-20 CN CN201780047555.3A patent/CN109844098A/en active Pending
- 2017-06-20 JP JP2019518148A patent/JP7525263B2/en active Active
- 2017-06-20 KR KR1020197001809A patent/KR102478617B1/en active IP Right Grant
- 2017-06-20 BR BR112018076554-6A patent/BR112018076554A2/en unknown
- 2017-06-20 US US16/310,933 patent/US20210047618A1/en active Pending
- 2017-06-20 KR KR1020227043758A patent/KR20230004913A/en not_active Application Discontinuation
- 2017-06-20 MX MX2018016258A patent/MX2018016258A/en unknown
- 2017-06-20 WO PCT/EP2017/065101 patent/WO2017220586A1/en unknown
- 2017-06-20 EP EP17732860.6A patent/EP3472302A1/en active Pending
-
2018
- 2018-12-20 IL IL263854A patent/IL263854A/en unknown
-
2022
- 2022-02-21 JP JP2022024460A patent/JP2022068302A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2017220586A1 (en) | 2017-12-28 |
RU2018145539A3 (en) | 2021-03-19 |
MX2018016258A (en) | 2019-05-20 |
CN109844098A (en) | 2019-06-04 |
KR102478617B1 (en) | 2022-12-19 |
CA3030098A1 (en) | 2017-12-28 |
GB201610748D0 (en) | 2016-08-03 |
JP2019527068A (en) | 2019-09-26 |
IL263854A (en) | 2019-02-03 |
AU2017281406A1 (en) | 2019-01-17 |
US20210047618A1 (en) | 2021-02-18 |
KR20190028443A (en) | 2019-03-18 |
BR112018076554A2 (en) | 2019-04-02 |
JP2022068302A (en) | 2022-05-09 |
JP7525263B2 (en) | 2024-07-30 |
EP3472302A1 (en) | 2019-04-24 |
KR20230004913A (en) | 2023-01-06 |
AU2017281406B2 (en) | 2022-07-14 |
RU2018145539A (en) | 2020-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201811405QA (en) | Improved differentiation method | |
SG11201806988UA (en) | Improved differentiation method | |
SG11201903882VA (en) | Il-2 variants for the treatment of autoimmune diseases | |
SG11201805320XA (en) | Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration | |
SG11201810591VA (en) | Bispecific binding proteins binding an immunomodulatory protein and a tumor antigen | |
SG11201909955XA (en) | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies | |
SG11201909949XA (en) | Targeted immunotolerance | |
SG11201805422WA (en) | Multivalent and multispecific ox40-binding fusion proteins | |
SG11201806758VA (en) | Vcn enhancer compositions and methods of using the same | |
SG11201903928WA (en) | Mesenchymal stem cells populations, their products, and use thereof | |
SG11201804161VA (en) | Compositions comprising bacterial strains | |
SG11201806639VA (en) | New streptococcal proteases | |
SG11201806398YA (en) | Optimized factor viii genes | |
SG11201407580YA (en) | Composition comprising two antibodies engineered to have reduced and increased effector function | |
SG11201805420SA (en) | Antibodies and conjugates thereof | |
SG11201805709RA (en) | Anti-pro/latent myostatin antibodies and methods of use thereof | |
SG11201804510PA (en) | Biparatopic polypeptides antagonizing wnt signaling in tumor cells | |
SG11201907023UA (en) | Method of reducing neutropenia | |
SG11201407417VA (en) | Encoding and reconstruction of residual data based on support information | |
SG11201909303TA (en) | Point of delivery cold slurry generation | |
SG11201908092RA (en) | Anti-tigit antigen-binding proteins and methods of use thereof | |
SG11201906961UA (en) | Polypeptide variants and uses thereof | |
SG11201404836QA (en) | Long-acting coagulation factors and methods of producing same | |
SG11201907208XA (en) | Radiolabeled anti-lag3 antibodies for immuno-pet imaging | |
SG11201808592PA (en) | Method for selection of high m6p recombinant proteins |