GB201518665D0 - Method for enrichment of cell free nucleosomes - Google Patents
Method for enrichment of cell free nucleosomesInfo
- Publication number
- GB201518665D0 GB201518665D0 GBGB1518665.3A GB201518665A GB201518665D0 GB 201518665 D0 GB201518665 D0 GB 201518665D0 GB 201518665 A GB201518665 A GB 201518665A GB 201518665 D0 GB201518665 D0 GB 201518665D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- enrichment
- cell free
- free nucleosomes
- nucleosomes
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 108010047956 Nucleosomes Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 210000001623 nucleosome Anatomy 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/12—Post-translational modifications [PTMs] in chemical analysis of biological material alkylation, e.g. methylation, (iso-)prenylation, farnesylation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1518665.3A GB201518665D0 (en) | 2015-10-21 | 2015-10-21 | Method for enrichment of cell free nucleosomes |
| AU2016341501A AU2016341501B2 (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
| ES16787545T ES2830800T3 (es) | 2015-10-21 | 2016-10-21 | Método para el enriquecimiento de nucleosomas libres de células |
| US15/768,984 US10746746B2 (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
| DK16787545.9T DK3365684T3 (da) | 2015-10-21 | 2016-10-21 | Fremgangsmåde til berigelse af cellefrie nukleosomer |
| PCT/GB2016/053305 WO2017068371A1 (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
| CA3002505A CA3002505A1 (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
| JP2018520599A JP6831841B2 (ja) | 2015-10-21 | 2016-10-21 | 無細胞ヌクレオソームの濃縮のための方法 |
| EP16787545.9A EP3365684B1 (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
| PL16787545T PL3365684T3 (pl) | 2015-10-21 | 2016-10-21 | Sposób wzbogacania nukleosomów pozakomórkowych |
| SG11201803161YA SG11201803161YA (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
| CN201680074815.1A CN108603884A (zh) | 2015-10-21 | 2016-10-21 | 富集无细胞核小体的方法 |
| EP20190999.1A EP3798634A1 (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
| US16/929,016 US20200340997A1 (en) | 2015-10-21 | 2020-07-14 | Method for the enrichment of cell free nucleosomes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1518665.3A GB201518665D0 (en) | 2015-10-21 | 2015-10-21 | Method for enrichment of cell free nucleosomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201518665D0 true GB201518665D0 (en) | 2015-12-02 |
Family
ID=55131411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB1518665.3A Ceased GB201518665D0 (en) | 2015-10-21 | 2015-10-21 | Method for enrichment of cell free nucleosomes |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10746746B2 (enExample) |
| EP (2) | EP3365684B1 (enExample) |
| JP (1) | JP6831841B2 (enExample) |
| CN (1) | CN108603884A (enExample) |
| AU (1) | AU2016341501B2 (enExample) |
| CA (1) | CA3002505A1 (enExample) |
| DK (1) | DK3365684T3 (enExample) |
| ES (1) | ES2830800T3 (enExample) |
| GB (1) | GB201518665D0 (enExample) |
| PL (1) | PL3365684T3 (enExample) |
| SG (1) | SG11201803161YA (enExample) |
| WO (1) | WO2017068371A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1206055A1 (en) | 2012-03-02 | 2015-12-31 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP2971100A1 (en) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primers for dna methylation analysis |
| EP3736344A1 (en) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| PL3685165T3 (pl) * | 2017-09-18 | 2022-08-08 | Santersus Ag | Sposób i urządzenie do oczyszczania krwi z krążącego pozakomórkowego dna |
| EP4215621B1 (en) | 2018-03-01 | 2025-05-28 | Epicypher, Inc. | Quantification of nucleosome modifications using chemically-defined recombinant nucleosomes |
| EP3765638A2 (en) | 2018-03-13 | 2021-01-20 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Diagnostic use of cell free dna chromatin immunoprecipitation |
| CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用 |
| GB201906199D0 (en) * | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| EP3757227A1 (en) * | 2019-06-25 | 2020-12-30 | Aarhus Universitet | Cell-free chromatin immunoprecipitation (cfchip) as a measure of tumour gene expression in a sample |
| GB201912251D0 (en) | 2019-08-27 | 2019-10-09 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| US20220290252A1 (en) * | 2019-08-27 | 2022-09-15 | Belgian Volition Srl | Method of isolating circulating nucleosomes |
| CN114829939B (zh) * | 2019-12-02 | 2025-10-21 | 比利时意志有限责任公司 | 无细胞核小体作为生物标志物的用途 |
| TW202242145A (zh) * | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| US12053567B2 (en) | 2021-12-27 | 2024-08-06 | Santersus Ag | Method and device for removal of circulating cell free DNA |
| WO2024042210A1 (en) * | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | Method for measuring cell free chromatin |
| GB202300607D0 (en) | 2023-01-16 | 2023-03-01 | Belgian Volition Srl | Proteins and methods for isolating circulating nucleosomes |
| TW202530419A (zh) | 2023-10-04 | 2025-08-01 | 比利時商比利時意志有限公司 | Pcr方法 |
| CN117904196B (zh) * | 2024-01-05 | 2024-07-12 | 安徽大学 | 一种非小细胞肺癌组蛋白h1.4赖氨酸乙酰化点突变细胞模型的构建及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807999A (en) | 1993-02-01 | 1998-09-15 | Mt. Sinai School Of Medicine Of The City University Of New York | Monoclonal antibody that distinguishes between phosphorylated and nonphosphorylated histone H1 and uses therefor |
| GB0319376D0 (en) * | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| EP2496717B1 (en) | 2009-11-05 | 2017-06-07 | The Chinese University of Hong Kong | Fetal genomic analysis from a maternal biological sample |
| WO2011092715A2 (en) | 2010-01-27 | 2011-08-04 | Tata Memorial Centre | Method for in-vivo binding of chromatin fragments |
| US8981066B2 (en) | 2011-08-23 | 2015-03-17 | Buck Institute For Research On Aging | Epigenetic mechanisms related to DNA damage and aging |
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115099D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| EP2788767B1 (en) | 2011-12-07 | 2017-09-06 | Belgian Volition SPRL | Method for detecting nucleosome adducts |
| HK1206055A1 (en) * | 2012-03-02 | 2015-12-31 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
-
2015
- 2015-10-21 GB GBGB1518665.3A patent/GB201518665D0/en not_active Ceased
-
2016
- 2016-10-21 WO PCT/GB2016/053305 patent/WO2017068371A1/en not_active Ceased
- 2016-10-21 EP EP16787545.9A patent/EP3365684B1/en active Active
- 2016-10-21 US US15/768,984 patent/US10746746B2/en active Active
- 2016-10-21 CA CA3002505A patent/CA3002505A1/en active Pending
- 2016-10-21 JP JP2018520599A patent/JP6831841B2/ja not_active Expired - Fee Related
- 2016-10-21 AU AU2016341501A patent/AU2016341501B2/en not_active Ceased
- 2016-10-21 SG SG11201803161YA patent/SG11201803161YA/en unknown
- 2016-10-21 PL PL16787545T patent/PL3365684T3/pl unknown
- 2016-10-21 CN CN201680074815.1A patent/CN108603884A/zh active Pending
- 2016-10-21 EP EP20190999.1A patent/EP3798634A1/en not_active Withdrawn
- 2016-10-21 DK DK16787545.9T patent/DK3365684T3/da active
- 2016-10-21 ES ES16787545T patent/ES2830800T3/es active Active
-
2020
- 2020-07-14 US US16/929,016 patent/US20200340997A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3365684A1 (en) | 2018-08-29 |
| WO2017068371A1 (en) | 2017-04-27 |
| JP6831841B2 (ja) | 2021-02-17 |
| ES2830800T3 (es) | 2021-06-04 |
| EP3365684B1 (en) | 2020-09-23 |
| SG11201803161YA (en) | 2018-05-30 |
| AU2016341501A1 (en) | 2018-05-10 |
| PL3365684T3 (pl) | 2021-05-04 |
| US10746746B2 (en) | 2020-08-18 |
| AU2016341501B2 (en) | 2022-09-08 |
| DK3365684T3 (da) | 2020-12-21 |
| US20200340997A1 (en) | 2020-10-29 |
| EP3798634A1 (en) | 2021-03-31 |
| CN108603884A (zh) | 2018-09-28 |
| JP2019500582A (ja) | 2019-01-10 |
| CA3002505A1 (en) | 2017-04-27 |
| US20190064184A1 (en) | 2019-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AT | Applications terminated before publication under section 16(1) |