DK3365684T3 - Fremgangsmåde til berigelse af cellefrie nukleosomer - Google Patents
Fremgangsmåde til berigelse af cellefrie nukleosomer Download PDFInfo
- Publication number
- DK3365684T3 DK3365684T3 DK16787545.9T DK16787545T DK3365684T3 DK 3365684 T3 DK3365684 T3 DK 3365684T3 DK 16787545 T DK16787545 T DK 16787545T DK 3365684 T3 DK3365684 T3 DK 3365684T3
- Authority
- DK
- Denmark
- Prior art keywords
- enrichment
- procedure
- cell
- free nucleosomes
- nucleosomes
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/12—Post-translational modifications [PTMs] in chemical analysis of biological material alkylation, e.g. methylation, (iso-)prenylation, farnesylation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1518665.3A GB201518665D0 (en) | 2015-10-21 | 2015-10-21 | Method for enrichment of cell free nucleosomes |
| PCT/GB2016/053305 WO2017068371A1 (en) | 2015-10-21 | 2016-10-21 | Method for the enrichment of cell free nucleosomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3365684T3 true DK3365684T3 (da) | 2020-12-21 |
Family
ID=55131411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16787545.9T DK3365684T3 (da) | 2015-10-21 | 2016-10-21 | Fremgangsmåde til berigelse af cellefrie nukleosomer |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10746746B2 (da) |
| EP (2) | EP3798634A1 (da) |
| JP (1) | JP6831841B2 (da) |
| CN (1) | CN108603884A (da) |
| AU (1) | AU2016341501B2 (da) |
| CA (1) | CA3002505A1 (da) |
| DK (1) | DK3365684T3 (da) |
| ES (1) | ES2830800T3 (da) |
| GB (1) | GB201518665D0 (da) |
| PL (1) | PL3365684T3 (da) |
| SG (1) | SG11201803161YA (da) |
| WO (1) | WO2017068371A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2930180T3 (es) | 2012-03-02 | 2022-12-07 | Sequenom Inc | Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica |
| WO2014168711A1 (en) | 2013-03-13 | 2014-10-16 | Sequenom, Inc. | Primers for dna methylation analysis |
| EP3736344A1 (en) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA3084620C (en) * | 2017-09-18 | 2024-06-18 | Santersus Sa | Method and device for purification of blood from circulating cell free dna |
| ES2960550T3 (es) * | 2018-03-01 | 2024-03-05 | Epicypher Inc | Cuantificación de modificaciones de nucleosoma utilizando nucleosomas recombinantes definidos químicamente |
| EP3765638A2 (en) * | 2018-03-13 | 2021-01-20 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Diagnostic use of cell free dna chromatin immunoprecipitation |
| CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用 |
| GB201906199D0 (en) * | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| EP3757227A1 (en) * | 2019-06-25 | 2020-12-30 | Aarhus Universitet | Cell-free chromatin immunoprecipitation (cfchip) as a measure of tumour gene expression in a sample |
| CN114901832A (zh) | 2019-08-27 | 2022-08-12 | 比利时意志有限责任公司 | 分离循环核小体的方法 |
| GB201912251D0 (en) | 2019-08-27 | 2019-10-09 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| TW202242145A (zh) * | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| WO2023126672A1 (en) | 2021-12-27 | 2023-07-06 | Santersus Ag | Method and device for removal of circulating cell free dna |
| WO2024042210A1 (en) * | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | Method for measuring cell free chromatin |
| GB202300607D0 (en) | 2023-01-16 | 2023-03-01 | Belgian Volition Srl | Proteins and methods for isolating circulating nucleosomes |
| CN117904196B (zh) * | 2024-01-05 | 2024-07-12 | 安徽大学 | 一种非小细胞肺癌组蛋白h1.4赖氨酸乙酰化点突变细胞模型的构建及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807999A (en) | 1993-02-01 | 1998-09-15 | Mt. Sinai School Of Medicine Of The City University Of New York | Monoclonal antibody that distinguishes between phosphorylated and nonphosphorylated histone H1 and uses therefor |
| GB0319376D0 (en) * | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| HUE061110T2 (hu) | 2009-11-05 | 2023-05-28 | Univ Hong Kong Chinese | Magzati genomelemzés anyai biológiai mintából |
| WO2011092715A2 (en) | 2010-01-27 | 2011-08-04 | Tata Memorial Centre | Method for in-vivo binding of chromatin fragments |
| US8981066B2 (en) | 2011-08-23 | 2015-03-17 | Buck Institute For Research On Aging | Epigenetic mechanisms related to DNA damage and aging |
| GB201115098D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115099D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes |
| GB201115095D0 (en) * | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| RU2634266C2 (ru) * | 2011-12-07 | 2017-10-24 | Белджиан Волишн Спрл | Способ детекции аддуктов нуклеосом |
| ES2930180T3 (es) * | 2012-03-02 | 2022-12-07 | Sequenom Inc | Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica |
-
2015
- 2015-10-21 GB GBGB1518665.3A patent/GB201518665D0/en not_active Ceased
-
2016
- 2016-10-21 WO PCT/GB2016/053305 patent/WO2017068371A1/en active Application Filing
- 2016-10-21 EP EP20190999.1A patent/EP3798634A1/en not_active Withdrawn
- 2016-10-21 US US15/768,984 patent/US10746746B2/en active Active
- 2016-10-21 PL PL16787545T patent/PL3365684T3/pl unknown
- 2016-10-21 DK DK16787545.9T patent/DK3365684T3/da active
- 2016-10-21 JP JP2018520599A patent/JP6831841B2/ja active Active
- 2016-10-21 CA CA3002505A patent/CA3002505A1/en active Pending
- 2016-10-21 ES ES16787545T patent/ES2830800T3/es active Active
- 2016-10-21 EP EP16787545.9A patent/EP3365684B1/en active Active
- 2016-10-21 SG SG11201803161YA patent/SG11201803161YA/en unknown
- 2016-10-21 CN CN201680074815.1A patent/CN108603884A/zh active Pending
- 2016-10-21 AU AU2016341501A patent/AU2016341501B2/en not_active Ceased
-
2020
- 2020-07-14 US US16/929,016 patent/US20200340997A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017068371A1 (en) | 2017-04-27 |
| PL3365684T3 (pl) | 2021-05-04 |
| EP3365684B1 (en) | 2020-09-23 |
| CN108603884A (zh) | 2018-09-28 |
| CA3002505A1 (en) | 2017-04-27 |
| AU2016341501B2 (en) | 2022-09-08 |
| US20190064184A1 (en) | 2019-02-28 |
| SG11201803161YA (en) | 2018-05-30 |
| AU2016341501A1 (en) | 2018-05-10 |
| EP3798634A1 (en) | 2021-03-31 |
| GB201518665D0 (en) | 2015-12-02 |
| JP6831841B2 (ja) | 2021-02-17 |
| US10746746B2 (en) | 2020-08-18 |
| EP3365684A1 (en) | 2018-08-29 |
| JP2019500582A (ja) | 2019-01-10 |
| US20200340997A1 (en) | 2020-10-29 |
| ES2830800T3 (es) | 2021-06-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3365684T3 (da) | Fremgangsmåde til berigelse af cellefrie nukleosomer | |
| DK3192902T3 (da) | Fremgangsmåde til fremstilling af graphenholdige viscosefibre | |
| DK3292134T3 (da) | Metode til dyrkning af akkermansia | |
| DK3317400T3 (da) | Fremgangsmåde til kryokonservering af tumorinfiltrerende lymfocytter | |
| DK3096741T3 (da) | Fremgangsmåde til fremstillingen af hybridosomer | |
| DK3325443T3 (da) | Fremgangsmåde til fremstilling af pridopidin | |
| DK3160956T3 (da) | Inhibitorer af lysin-specifik demethylase-1 | |
| DK3137169T3 (da) | Hæmmere af lysin-specifik demethylase-1 | |
| DK3102576T3 (da) | Dihydropyrrolopyridininhibitorer af ror-gamma | |
| DK3102673T3 (da) | Fremgangsmåder og sammensætninger til behandling af beta-talassæmi | |
| DK3174858T3 (da) | Fremgangsmåde til fremstilling af pyrazoler | |
| DK3511319T3 (da) | Hæmmere af lysinspecifik demethylase-1 | |
| DK3201361T3 (da) | Fremgangsmåder til kvantificering af cellefrit DNA | |
| DK3048295T3 (da) | Fremgangsmåde til opførelse af en vindmølle og vindmølle | |
| DK3280408T3 (da) | Fremgangsmåde til fremstilling af dicycloplatin | |
| DK3166612T3 (da) | Fremgangsmåde til fremstilling af 4-alkoxy-3-hydroxy-picolinsyre | |
| DK3191498T3 (da) | Fremgangsmåde til fremstilling af 2'-o-fucosyllactose | |
| DK3390422T3 (da) | Krystalformer af lnt | |
| DK3487986T3 (da) | Fremgangsmåde til mikrobiel fremstilling af specifikke naturlige capsaicinoider | |
| DK3204352T3 (da) | Hæmmere af lysin-gingipain | |
| DK3137449T3 (da) | Fremgangsmåder til fremstilling af substituerede cycloseriner | |
| DK3277801T3 (da) | Fremgangsmåde til fremstilling af otiske progenitorer | |
| DK3328574T3 (da) | Fremgangsmåde til fremstilling af en monotektisk legering | |
| DK3529236T3 (da) | Krystalformer af eravacyclin | |
| DK3116854T3 (da) | Ny fremgangsmåde til fremstilling af prostaglandiner med høj renhed |