GB1562373A - Synthetic membrane for wound-dressing - Google Patents
Synthetic membrane for wound-dressing Download PDFInfo
- Publication number
- GB1562373A GB1562373A GB1780/78A GB178078A GB1562373A GB 1562373 A GB1562373 A GB 1562373A GB 1780/78 A GB1780/78 A GB 1780/78A GB 178078 A GB178078 A GB 178078A GB 1562373 A GB1562373 A GB 1562373A
- Authority
- GB
- United Kingdom
- Prior art keywords
- layer
- membrane
- copolymer
- membrane according
- leucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/716—Degradable
- B32B2307/7163—Biodegradable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/728—Hydrophilic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2535/00—Medical equipment, e.g. bandage, prostheses or catheter
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S602/00—Surgery: splint, brace, or bandage
- Y10S602/90—Method of making bandage structure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249961—With gradual property change within a component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31725—Of polyamide
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Synthetic Leather, Interior Materials Or Flexible Sheet Materials (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH57677A CH625702A5 (el) | 1977-01-18 | 1977-01-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1562373A true GB1562373A (en) | 1980-03-12 |
Family
ID=4190199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1780/78A Expired GB1562373A (en) | 1977-01-18 | 1978-01-17 | Synthetic membrane for wound-dressing |
Country Status (19)
Country | Link |
---|---|
US (1) | US4161948A (el) |
JP (1) | JPS5390691A (el) |
AU (1) | AU513271B2 (el) |
BE (1) | BE862981A (el) |
BR (1) | BR7800285A (el) |
CA (1) | CA1092026A (el) |
CH (1) | CH625702A5 (el) |
DE (1) | DE2802295C2 (el) |
DK (1) | DK148784C (el) |
ES (1) | ES466119A1 (el) |
FR (1) | FR2377205A1 (el) |
GB (1) | GB1562373A (el) |
GR (1) | GR61991B (el) |
IT (1) | IT1092286B (el) |
LU (1) | LU78882A1 (el) |
MX (1) | MX5547E (el) |
NL (1) | NL7800531A (el) |
SE (1) | SE439244B (el) |
ZA (1) | ZA78285B (el) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2444323A (en) * | 2006-11-30 | 2008-06-04 | Ethicon Inc | Cellular protein sheet material |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0016480B1 (de) * | 1979-03-15 | 1983-02-16 | GebràDer Sulzer Aktiengesellschaft | Strumpfartiger Überzug für den Verankerungsschaft einer Endoprothese |
US4361552A (en) * | 1980-09-26 | 1982-11-30 | Board Of Regents, The University Of Texas System | Wound dressing |
FR2524304B1 (fr) * | 1982-03-31 | 1985-06-14 | Delalande Sa | Peau artificielle |
CA1212879A (en) * | 1982-07-21 | 1986-10-21 | Laszlo Juhasz | Composite wound dressing |
SE448821B (sv) * | 1984-02-03 | 1987-03-23 | Medinvent Sa | Flerskiktat nedbrytbart material avsett som ersettning for kroppsvevnad och vars nedbrytningshastighet varierar med avstandet fran den exponerade ytan forfarande for dess framstellning |
SE452404B (sv) * | 1984-02-03 | 1987-11-30 | Medinvent Sa | Flerskiktat protesmaterial samt forfarande for dess framstellning |
SE456274B (sv) * | 1984-02-03 | 1988-09-19 | Carl Gustaf Mellsjo | Anordning vid vermevexlare for att ge det ena mediet en skruvformig cirkulationsrorelse |
JPS60261460A (ja) * | 1984-06-11 | 1985-12-24 | 株式会社 高研 | コラ−ゲンとポリ―α―アミノ酸膜から成る人工皮膚 |
ATE60340T1 (de) * | 1984-10-19 | 1991-02-15 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
SE452110B (sv) * | 1984-11-08 | 1987-11-16 | Medinvent Sa | Flerskiktat protesmaterial samt forfarande for dess framstellning |
EP0265906B1 (en) * | 1986-10-31 | 1995-04-19 | Nippon Zeon Co., Ltd. | Wound dressing |
FR2612392A1 (fr) * | 1987-03-19 | 1988-09-23 | Audion Michel | Composites biodegradables interrompus a resistance variable |
JPS642643A (en) * | 1987-06-26 | 1989-01-06 | Bio Material Yunibaasu:Kk | Artificial skin |
US5135754A (en) * | 1988-01-06 | 1992-08-04 | Delalande S.A. | Method of preparing a copolymer of two α-amino acids and a copolymer thus obtained |
US4906240A (en) * | 1988-02-01 | 1990-03-06 | Matrix Medica, Inc. | Adhesive-faced porous absorbent sheet and method of making same |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5702716A (en) * | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US5487897A (en) | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
USRE37950E1 (en) | 1990-04-24 | 2002-12-31 | Atrix Laboratories | Biogradable in-situ forming implants and methods of producing the same |
US5462990A (en) * | 1990-10-15 | 1995-10-31 | Board Of Regents, The University Of Texas System | Multifunctional organic polymers |
AU2605592A (en) * | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
WO1993010731A1 (en) * | 1991-12-06 | 1993-06-10 | Kensey Nash Corporation | Pads, methods of making, and methods of use for wound dressing, surgical reinforcement and hemostasis promotion |
US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
GB9206504D0 (en) * | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges as wound implants |
US5565210A (en) * | 1993-03-22 | 1996-10-15 | Johnson & Johnson Medical, Inc. | Bioabsorbable wound implant materials |
US5681873A (en) * | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
AU1060495A (en) * | 1993-12-01 | 1995-06-19 | Universite Du Quebec A Montreal | Albumin based hydrogel |
US6743248B2 (en) | 1996-12-18 | 2004-06-01 | Neomend, Inc. | Pretreatment method for enhancing tissue adhesion |
US6371975B2 (en) | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
US20040176801A1 (en) * | 1997-03-12 | 2004-09-09 | Neomend, Inc. | Pretreatment method for enhancing tissue adhesion |
US20030191496A1 (en) * | 1997-03-12 | 2003-10-09 | Neomend, Inc. | Vascular sealing device with microwave antenna |
US7128927B1 (en) | 1998-04-14 | 2006-10-31 | Qlt Usa, Inc. | Emulsions for in-situ delivery systems |
US6994686B2 (en) | 1998-08-26 | 2006-02-07 | Neomend, Inc. | Systems for applying cross-linked mechanical barriers |
US6458147B1 (en) | 1998-11-06 | 2002-10-01 | Neomend, Inc. | Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue |
US6949114B2 (en) | 1998-11-06 | 2005-09-27 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US7279001B2 (en) * | 1998-11-06 | 2007-10-09 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US6830756B2 (en) * | 1998-11-06 | 2004-12-14 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US6899889B1 (en) | 1998-11-06 | 2005-05-31 | Neomend, Inc. | Biocompatible material composition adaptable to diverse therapeutic indications |
US7476250B1 (en) * | 1999-04-06 | 2009-01-13 | Mansmann Kevin A | Semi-permeable membranes to assist in cartilage repair |
US8226598B2 (en) * | 1999-09-24 | 2012-07-24 | Tolmar Therapeutics, Inc. | Coupling syringe system and methods for obtaining a mixed composition |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US6833488B2 (en) | 2001-03-30 | 2004-12-21 | Exotech Bio Solution Ltd. | Biocompatible, biodegradable, water-absorbent material and methods for its preparation |
WO2003018665A1 (en) | 2001-08-22 | 2003-03-06 | Bioartificial Gel Technologies Inc. | Process for the preparation of activated polyethylene glycols |
US7351787B2 (en) * | 2004-03-05 | 2008-04-01 | Bioartificial Gel Technologies, Inc. | Process for the preparation of activated polyethylene glycols |
WO2006033766A2 (en) * | 2004-08-25 | 2006-03-30 | The Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
US20070041934A1 (en) * | 2005-08-12 | 2007-02-22 | Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
PT1937276E (pt) | 2005-10-12 | 2013-02-21 | Besins Healthcare Luxembourg | Gel de testosterona melhorado e método para a sua utilização |
CA2684725A1 (en) * | 2007-04-19 | 2009-01-15 | The Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
WO2009151687A2 (en) | 2008-03-12 | 2009-12-17 | The Regents Of The University Of Michigan | Dendrimer conjugates |
WO2010039861A2 (en) | 2008-09-30 | 2010-04-08 | The Regents Of The University Of Michigan | Dendrimer conjugates |
US9017644B2 (en) | 2008-11-07 | 2015-04-28 | The Regents Of The University Of Michigan | Methods of treating autoimmune disorders and/or inflammatory disorders |
CN102917699A (zh) | 2009-10-13 | 2013-02-06 | 密执安大学评议会 | 树枝状聚合物组合物和合成方法 |
US8912323B2 (en) | 2009-10-30 | 2014-12-16 | The Regents Of The University Of Michigan | Multifunctional small molecules |
CN102985153B (zh) | 2010-06-16 | 2015-02-11 | 日东电工株式会社 | 防水透气过滤器及其用途 |
KR102123195B1 (ko) | 2010-06-16 | 2020-06-15 | 닛토덴코 가부시키가이샤 | 방수 통기 필터 및 그의 용도 |
US9402911B2 (en) | 2011-12-08 | 2016-08-02 | The Regents Of The University Of Michigan | Multifunctional small molecules |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3875937A (en) * | 1963-10-31 | 1975-04-08 | American Cyanamid Co | Surgical dressings of absorbable polymers |
US3867520A (en) * | 1971-04-14 | 1975-02-18 | Ajinomoto Kk | Medicated polyamino acid film for occlusive dressing therapy |
JPS5031905B1 (el) * | 1971-07-05 | 1975-10-16 | ||
US3849238A (en) * | 1972-04-07 | 1974-11-19 | S Ronel | Artificial skin |
US3978266A (en) * | 1972-10-05 | 1976-08-31 | Ionics Lyo Products Company | Surgical dressings |
US3949742A (en) * | 1974-09-20 | 1976-04-13 | Frigitronics, Inc. | Medical dressing |
US3978855A (en) * | 1975-01-17 | 1976-09-07 | Ionics Lyo Products Company | Polyurethane foam surgical dressing |
US4060081A (en) * | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
-
1977
- 1977-01-18 CH CH57677A patent/CH625702A5/fr not_active IP Right Cessation
-
1978
- 1978-01-16 GR GR55171A patent/GR61991B/el unknown
- 1978-01-16 US US05/869,688 patent/US4161948A/en not_active Expired - Lifetime
- 1978-01-16 AU AU32447/78A patent/AU513271B2/en not_active Expired
- 1978-01-17 SE SE7800523A patent/SE439244B/xx not_active IP Right Cessation
- 1978-01-17 BE BE184379A patent/BE862981A/xx not_active IP Right Cessation
- 1978-01-17 LU LU78882A patent/LU78882A1/xx unknown
- 1978-01-17 MX MX786779U patent/MX5547E/es unknown
- 1978-01-17 DE DE2802295A patent/DE2802295C2/de not_active Expired
- 1978-01-17 NL NL7800531A patent/NL7800531A/xx not_active Application Discontinuation
- 1978-01-17 FR FR7801211A patent/FR2377205A1/fr active Granted
- 1978-01-17 JP JP286978A patent/JPS5390691A/ja active Pending
- 1978-01-17 DK DK22578A patent/DK148784C/da active
- 1978-01-17 GB GB1780/78A patent/GB1562373A/en not_active Expired
- 1978-01-17 ZA ZA00780285A patent/ZA78285B/xx unknown
- 1978-01-17 CA CA295,078A patent/CA1092026A/en not_active Expired
- 1978-01-17 BR BR7800285A patent/BR7800285A/pt unknown
- 1978-01-17 IT IT7819337A patent/IT1092286B/it active
- 1978-01-18 ES ES466119A patent/ES466119A1/es not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2444323A (en) * | 2006-11-30 | 2008-06-04 | Ethicon Inc | Cellular protein sheet material |
GB2444323B (en) * | 2006-11-30 | 2011-04-06 | Ethicon Inc | Protein sheet material |
Also Published As
Publication number | Publication date |
---|---|
AU3244778A (en) | 1979-07-26 |
SE7800523L (sv) | 1978-07-19 |
GR61991B (en) | 1979-02-14 |
DK148784C (da) | 1986-04-01 |
DK148784B (da) | 1985-09-30 |
NL7800531A (nl) | 1978-07-20 |
CA1092026A (en) | 1980-12-23 |
MX5547E (es) | 1983-10-05 |
LU78882A1 (fr) | 1978-09-18 |
BR7800285A (pt) | 1978-09-05 |
CH625702A5 (el) | 1981-10-15 |
SE439244B (sv) | 1985-06-10 |
AU513271B2 (en) | 1980-11-20 |
IT1092286B (it) | 1985-07-06 |
DE2802295C2 (de) | 1982-09-16 |
IT7819337A0 (it) | 1978-01-17 |
ES466119A1 (es) | 1979-05-01 |
JPS5390691A (en) | 1978-08-09 |
FR2377205B1 (el) | 1981-12-11 |
ZA78285B (en) | 1978-12-27 |
DE2802295A1 (de) | 1978-07-20 |
FR2377205A1 (fr) | 1978-08-11 |
DK22578A (da) | 1978-07-19 |
US4161948A (en) | 1979-07-24 |
BE862981A (fr) | 1978-07-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |