GB1521505A - Preparations containing silicone elastomers and pharmacologically active substances - Google Patents
Preparations containing silicone elastomers and pharmacologically active substancesInfo
- Publication number
- GB1521505A GB1521505A GB38945/75A GB3894575A GB1521505A GB 1521505 A GB1521505 A GB 1521505A GB 38945/75 A GB38945/75 A GB 38945/75A GB 3894575 A GB3894575 A GB 3894575A GB 1521505 A GB1521505 A GB 1521505A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sio
- pbw
- units
- composition
- polysiloxane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000013543 active substance Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229920002379 silicone rubber Polymers 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 10
- 229920001296 polysiloxane Polymers 0.000 abstract 7
- -1 polysiloxane Polymers 0.000 abstract 6
- 238000000465 moulding Methods 0.000 abstract 5
- 229910004298 SiO 2 Inorganic materials 0.000 abstract 4
- 229920001577 copolymer Polymers 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 abstract 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000004205 dimethyl polysiloxane Substances 0.000 abstract 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 abstract 1
- 229930182833 estradiol Natural products 0.000 abstract 1
- 229960002568 ethinylestradiol Drugs 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 229960004400 levonorgestrel Drugs 0.000 abstract 1
- 229960004296 megestrol acetate Drugs 0.000 abstract 1
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 abstract 1
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 abstract 1
- 229960001390 mestranol Drugs 0.000 abstract 1
- 229960001652 norethindrone acetate Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/2036—Silicones; Polysiloxanes
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742445971 DE2445971A1 (de) | 1974-09-24 | 1974-09-24 | Arzneimittelwirkstofftraeger ii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1521505A true GB1521505A (en) | 1978-08-16 |
Family
ID=5926793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB38945/75A Expired GB1521505A (en) | 1974-09-24 | 1975-09-23 | Preparations containing silicone elastomers and pharmacologically active substances |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4012497A (enExample) |
| JP (1) | JPS5161618A (enExample) |
| AT (1) | AT347588B (enExample) |
| AU (1) | AU498204B2 (enExample) |
| BE (1) | BE833762A (enExample) |
| BG (1) | BG27880A3 (enExample) |
| CA (1) | CA1049408A (enExample) |
| CH (1) | CH624580A5 (enExample) |
| DD (1) | DD122197A5 (enExample) |
| DE (1) | DE2445971A1 (enExample) |
| DK (1) | DK143384C (enExample) |
| EG (1) | EG11859A (enExample) |
| ES (1) | ES441203A1 (enExample) |
| FI (1) | FI58871C (enExample) |
| FR (1) | FR2285895A1 (enExample) |
| GB (1) | GB1521505A (enExample) |
| HU (1) | HU175675B (enExample) |
| IE (1) | IE41717B1 (enExample) |
| IL (1) | IL48100A (enExample) |
| IN (1) | IN142359B (enExample) |
| IT (1) | IT1042731B (enExample) |
| NL (1) | NL7511244A (enExample) |
| NO (1) | NO753230L (enExample) |
| PL (1) | PL105375B1 (enExample) |
| SE (1) | SE7510658L (enExample) |
| SU (1) | SU605547A3 (enExample) |
| ZA (1) | ZA756082B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2252497A (en) * | 1991-02-04 | 1992-08-12 | Elsimar Metzker Coutinho | Progesterone compositions for treating endometriosis |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| US4219016A (en) * | 1978-12-07 | 1980-08-26 | The Procter & Gamble Company | Vaginal contraceptive |
| US4191741A (en) * | 1978-09-22 | 1980-03-04 | Eli Lilly And Company | Removable drug implant |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| US4200090A (en) * | 1979-01-15 | 1980-04-29 | The Procter & Gamble Company | Vaginal contraceptive and method of using |
| US4264576A (en) * | 1979-06-28 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4343788A (en) * | 1979-06-29 | 1982-08-10 | The Procter & Gamble Company | Antimicrobial polymer compositions |
| US4479795A (en) * | 1979-06-29 | 1984-10-30 | The Procter & Gamble Company | Antimicrobial polymer compositions |
| US4264575A (en) * | 1979-07-16 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4264578A (en) * | 1979-07-16 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4264577A (en) * | 1979-08-03 | 1981-04-28 | Eli Lilly And Company | Contraceptive methods and compositions |
| US4341728A (en) * | 1979-12-20 | 1982-07-27 | The Population Council, Inc. | Method for making an IUD with shrinking of a medicated attachment onto a support |
| US4304226A (en) * | 1980-03-03 | 1981-12-08 | The Procter & Gamble Company | Vaginal contraceptive |
| AU538961B2 (en) * | 1980-06-09 | 1984-09-06 | Alex Harvey Industries Limited | Intra-vaginal device |
| DE3040978A1 (de) * | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Vaginalring |
| EP0076068A3 (en) * | 1981-09-25 | 1985-05-15 | Beecham Group Plc | Intramammary veterinary compositions and method for their use |
| NZ200564A (en) * | 1982-05-10 | 1987-03-06 | Ahi Operations Ltd | Device for slowly releasing chemicals into body cavities of animals |
| US4435180A (en) | 1982-05-25 | 1984-03-06 | Alza Corporation | Elastomeric active agent delivery system and method of use |
| US4563184A (en) * | 1983-10-17 | 1986-01-07 | Bernard Korol | Synthetic resin wound dressing and method of treatment using same |
| FR2560768A1 (fr) * | 1984-03-07 | 1985-09-13 | Crb Virbac Sa | Dispositif a liberation programmee |
| JPS61503003A (ja) * | 1984-04-19 | 1986-12-25 | ユニバ−シテイ− オブ クイ−ンスランド | 避妊方法、避妊用製剤及び避妊具 |
| US4673565A (en) * | 1985-05-03 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Pharmaceutical compositions containing hollow fine tubular drug delivery systems |
| NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
| US5560922A (en) * | 1986-05-30 | 1996-10-01 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process |
| US5238679A (en) * | 1987-02-26 | 1993-08-24 | Rhone-Poulenc Chimie | Diorganopolysiloxane dosage forms for the controlled release of iodine values |
| FR2611735B1 (fr) * | 1987-02-26 | 1989-06-16 | Rhone Poulenc Chimie | Composition elastomere silicone polyaddition contenant de l'iode pour le traitement de l'eau |
| FR2611733B1 (fr) * | 1987-02-26 | 1989-06-16 | Rhone Poulenc Chimie | Composition a base de gomme diorganopolysiloxane contenant de l'iode pour le traitement des eaux |
| FR2611734B1 (fr) * | 1987-02-26 | 1989-06-16 | Rhone Poulenc Chimie | Composition elastomere silicone polycondensation contenant de l'iode pour le traitement des eaux |
| US4879304A (en) * | 1987-05-01 | 1989-11-07 | Angelini Pharmaceuticals Ltd. | Ophthalmic compositions and process for preparing |
| HU197519B (en) * | 1987-06-22 | 1989-04-28 | Biogal Gyogyszergyar | Process for producing medicine form capable for penetrating through epidermis and suitable for intaking the agent through epidermis by kinetics of zero-grade |
| DE3727180A1 (de) * | 1987-08-14 | 1989-02-23 | Wacker Chemie Gmbh | Waessrige silicondispersionen |
| US5019378A (en) * | 1987-12-29 | 1991-05-28 | Cuno, Incorporated | Elastomeric composition containing therapeutic agents and articles manufactured therefrom |
| US4867968A (en) * | 1987-12-29 | 1989-09-19 | Florida-Kansas Health Care, Inc. | Elastomeric composition containing therapeutic agents and articles manufactured therefrom |
| US5019601A (en) * | 1987-12-29 | 1991-05-28 | Cuno, Incorporated | Elastomeric composition containing therapeutic agents and articles manufactured therefrom |
| US4879294A (en) * | 1988-01-28 | 1989-11-07 | Angelini Pharmaceuticals Ltd. | Opthalmic composition |
| US4906475A (en) * | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
| JP2590358B2 (ja) * | 1988-03-01 | 1997-03-12 | 正雄 五十嵐 | 子宮内膜症治療用の子宮内又は膣内投与製剤 |
| DE3838815A1 (de) * | 1988-11-17 | 1990-05-23 | Hoechst Ag | Verfahren zum herstellen eines intravaginalen applikationssystems |
| US5620499A (en) * | 1992-12-14 | 1997-04-15 | Farley; James J. | Chemical dispensing device and method |
| US5505963A (en) * | 1993-04-07 | 1996-04-09 | Schwartz Pharma Ag | Slow release pharmaceutical preparation |
| CA2342587C (en) * | 1998-09-10 | 2008-11-18 | Sumitomo Pharmaceuticals Co., Ltd. | Long term drug-sustained release preparation |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| EP1545705A4 (en) | 2000-11-16 | 2010-04-28 | Microspherix Llc | FLEXIBLE AND / OR ELASTIC BRACHYTHERAPY SEED OR STRAND |
| CN1536986B (zh) * | 2001-03-27 | 2012-07-04 | 沃纳奇尔科特(爱尔兰)有限公司 | 用于抗微生物剂给药的阴道内药物递送装置 |
| WO2003080018A1 (en) * | 2002-03-27 | 2003-10-02 | Galen (Chemicals) Limited | Intravaginal matrix drug delivery devices |
| ES2335008T3 (es) * | 2003-04-24 | 2010-03-18 | Jagotec Ag | Comprimido con nucleo coloreado. |
| WO2006026844A1 (en) * | 2004-09-09 | 2006-03-16 | Biolab Sanus Farmacêutica Ltda. | Hormone delayed release composition on the basis of polyorganosiloxanes or ethylene vinyl acetate resp. process for its manufacture |
| US7862552B2 (en) * | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| EA015304B1 (ru) | 2006-08-03 | 2011-06-30 | Нитек Фарма Аг | Лечение ревматоидного заболевания глюкокортикоидами с отсроченным высвобождением |
| US20090269403A1 (en) * | 2008-04-24 | 2009-10-29 | Shaked Ze Ev | Oral contraceptive dosage forms and methods of making such dosage forms |
| US20100040671A1 (en) * | 2008-08-12 | 2010-02-18 | Ahmed Salah U | Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof |
| US8419793B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| US8420153B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
| EP2391369A1 (en) * | 2009-01-26 | 2011-12-07 | Nitec Pharma AG | Delayed-release glucocorticoid treatment of asthma |
| EP2566535A4 (en) * | 2010-05-03 | 2013-12-18 | Izhar Halahmi | DEVICE FOR ADMINISTERING A BIOACTIVE AGENT |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| PL2982352T3 (pl) * | 2014-06-28 | 2019-01-31 | Laboratorios Andrómaco S.A. | Krążek szyjki macicy zawierający progesteron do długotrwałego, przedłużonego i ciągłego uwalniania, stosowany w celu zapobiegania przed przedwczesnym porodem |
| JP6691715B2 (ja) | 2014-08-19 | 2020-05-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 局所的薬物送達のためのインプラント及びその使用 |
| US11338119B2 (en) * | 2020-03-20 | 2022-05-24 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11173291B2 (en) * | 2020-03-20 | 2021-11-16 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11344526B2 (en) | 2020-03-20 | 2022-05-31 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US12576063B2 (en) | 2020-03-20 | 2026-03-17 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| WO2025056040A1 (zh) * | 2023-09-13 | 2025-03-20 | 沈阳星华医药科技有限公司 | 药物组合物、载药棒芯、埋植剂及其制备方法、应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
-
1974
- 1974-09-24 DE DE19742445971 patent/DE2445971A1/de active Pending
-
1975
- 1975-08-27 IN IN1660/CAL/75A patent/IN142359B/en unknown
- 1975-09-10 EG EG540/75A patent/EG11859A/xx active
- 1975-09-12 IL IL48100A patent/IL48100A/xx unknown
- 1975-09-15 BG BG030981A patent/BG27880A3/xx unknown
- 1975-09-18 IE IE2049/75A patent/IE41717B1/en unknown
- 1975-09-22 AU AU85064/75A patent/AU498204B2/en not_active Expired
- 1975-09-22 DD DD188480A patent/DD122197A5/xx unknown
- 1975-09-22 AT AT724275A patent/AT347588B/de not_active IP Right Cessation
- 1975-09-23 IT IT27536/75A patent/IT1042731B/it active
- 1975-09-23 GB GB38945/75A patent/GB1521505A/en not_active Expired
- 1975-09-23 SU SU752174604A patent/SU605547A3/ru active
- 1975-09-23 SE SE7510658A patent/SE7510658L/xx unknown
- 1975-09-23 US US05/616,001 patent/US4012497A/en not_active Expired - Lifetime
- 1975-09-23 NO NO753230A patent/NO753230L/no unknown
- 1975-09-23 HU HU75SCHE537A patent/HU175675B/hu unknown
- 1975-09-23 FI FI752660A patent/FI58871C/fi not_active IP Right Cessation
- 1975-09-23 CH CH1229875A patent/CH624580A5/de not_active IP Right Cessation
- 1975-09-23 ES ES441203A patent/ES441203A1/es not_active Expired
- 1975-09-24 FR FR7529205A patent/FR2285895A1/fr active Granted
- 1975-09-24 CA CA236,245A patent/CA1049408A/en not_active Expired
- 1975-09-24 ZA ZA00756082A patent/ZA756082B/xx unknown
- 1975-09-24 NL NL7511244A patent/NL7511244A/xx not_active Application Discontinuation
- 1975-09-24 PL PL1975183556A patent/PL105375B1/pl unknown
- 1975-09-24 BE BE160326A patent/BE833762A/xx unknown
- 1975-09-24 DK DK428175A patent/DK143384C/da active
- 1975-09-25 JP JP50115955A patent/JPS5161618A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2252497A (en) * | 1991-02-04 | 1992-08-12 | Elsimar Metzker Coutinho | Progesterone compositions for treating endometriosis |
| GB2252497B (en) * | 1991-02-04 | 1995-01-18 | Elsimar Metzker Coutinho | Pharmaceutical composition |
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