GB1511997A - Method for purification and isolation of hepatitis virus for use in the preparation of vaccine - Google Patents
Method for purification and isolation of hepatitis virus for use in the preparation of vaccineInfo
- Publication number
- GB1511997A GB1511997A GB11415/77A GB1141577A GB1511997A GB 1511997 A GB1511997 A GB 1511997A GB 11415/77 A GB11415/77 A GB 11415/77A GB 1141577 A GB1141577 A GB 1141577A GB 1511997 A GB1511997 A GB 1511997A
- Authority
- GB
- United Kingdom
- Prior art keywords
- virus
- hepatitis
- march
- surface antigen
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000700605 Viruses Species 0.000 title abstract 4
- 208000006454 hepatitis Diseases 0.000 title abstract 2
- 231100000283 hepatitis Toxicity 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 241000700721 Hepatitis B virus Species 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229920000936 Agarose Polymers 0.000 abstract 1
- 229920001287 Chondroitin sulfate Polymers 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- -1 packed in a column Chemical compound 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7603386A SE420977B (sv) | 1976-03-18 | 1976-03-18 | Forfarande for rening och isolering av hepatitvirus for vaccinframstellning |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1511997A true GB1511997A (en) | 1978-05-24 |
Family
ID=20327330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11415/77A Expired GB1511997A (en) | 1976-03-18 | 1977-03-17 | Method for purification and isolation of hepatitis virus for use in the preparation of vaccine |
Country Status (10)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008039136A1 (en) * | 2006-09-29 | 2008-04-03 | Ge Healthcare Bio-Sciences Ab | Separation matrix for viral purification |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4181713A (en) * | 1978-10-30 | 1980-01-01 | Merck & Co., Inc. | Isolation of HBs Ag |
| US6297355B1 (en) | 1978-12-22 | 2001-10-02 | Biogen, Inc. | Polypeptides displaying HBV antigenicity or hbv antigen specificity |
| US4242324A (en) * | 1979-04-04 | 1980-12-30 | Merck & Co., Inc. | Hepatitis B antigen |
| US4395395A (en) * | 1979-05-21 | 1983-07-26 | The United States Of America As Represented By The Department Of Health And Human Services | Detection of non-A, non-B hepatitis associated antigen |
| PL133476B1 (en) * | 1981-06-10 | 1985-06-29 | Akad Medyczna | Method of obtaining pure antigen hba from human serum |
| AU8746582A (en) * | 1981-09-02 | 1983-03-10 | Biogen N.V. | Hepatitis b virus e type antigen |
| US4603112A (en) * | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US7767449B1 (en) * | 1981-12-24 | 2010-08-03 | Health Research Incorporated | Methods using modified vaccinia virus |
| US4511473A (en) * | 1982-02-09 | 1985-04-16 | Amf Incorporated | Fibrous media containing millimicron-sized particulates |
| JPS59164727A (ja) * | 1983-03-09 | 1984-09-17 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ウイルス表面抗原の精製方法 |
| JPS59219239A (ja) * | 1983-05-28 | 1984-12-10 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ウイルス表面抗原の精製方法 |
| US4515714A (en) * | 1983-03-09 | 1985-05-07 | Juridicial Foundation, The Chemo-Semo-Sero-Therapeutic Research Institute | Method for purification of hepatitis B virus surface antigen |
| CA1237998A (en) * | 1984-04-14 | 1988-06-14 | Akihiro Ginnaga | Method for purification of filamentous hemagglutinin |
| JPS6147185A (ja) * | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | 日本脳炎ウイルスの精製方法 |
| JPS6147186A (ja) * | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | インフルエンザウイルスの精製方法 |
| JPS6147187A (ja) * | 1984-08-10 | 1986-03-07 | Chemo Sero Therapeut Res Inst | 狂犬病ウイルスの精製方法 |
| JPS6153226A (ja) * | 1984-08-24 | 1986-03-17 | Chemo Sero Therapeut Res Inst | 単純ヘルペスサブユニツトワクチンの精製方法 |
| JPS61103895A (ja) * | 1984-10-26 | 1986-05-22 | Green Cross Corp:The | ＨＢｓＡｇの精製方法 |
| SE503844C2 (sv) | 1989-02-09 | 1996-09-16 | Pharmacia Ab | Förfarande för rening av streptokinaser |
| US5447859A (en) * | 1993-07-16 | 1995-09-05 | Viagene | Method for the purification or removal of retroviruses using sulfated cellulose |
| JP3615785B2 (ja) * | 1994-04-28 | 2005-02-02 | テルモ株式会社 | Ｈｉｖ及びその関連物質除去材料 |
| GB9804632D0 (en) * | 1998-03-05 | 1998-04-29 | Cantab Pharma Res | Virus preparations and methods |
| US6221855B1 (en) * | 1999-03-11 | 2001-04-24 | Wake Forest University | Regulation of nucleic acid expression by heparan sulfate and biological equivalents thereof |
| JP4558652B2 (ja) * | 2003-06-20 | 2010-10-06 | マイクロビクス・バイオシステムズ・インコーポレイテツド | ウイルス生産の改善 |
| MX360727B (es) * | 2004-06-01 | 2018-11-14 | Genzyme Corp | Composiciones y metodos para evitar la agregacion del vector aav. |
| CN114210310B (zh) * | 2021-12-06 | 2023-09-29 | 武汉瑞法医疗器械有限公司 | 乙型肝炎病毒和HBsAg免疫吸附材料的制备方法及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3636191A (en) * | 1969-10-08 | 1972-01-18 | Cancer Res Inst | Vaccine against viral hepatitis and process |
| US3925152A (en) * | 1971-06-18 | 1975-12-09 | Exploaterings Ab Tbf | Virus separation |
| US3896218A (en) * | 1972-07-13 | 1975-07-22 | Research Corp | Radiommunoassay determining the hepatitis associated antigen content of blood |
| US3994870A (en) * | 1974-01-31 | 1976-11-30 | The Community Blood Council Of Greater New York, Inc. | Purification of hepatitis B surface antigen |
| US3976767A (en) * | 1975-04-14 | 1976-08-24 | The New York Blood Center | Purification of hepatitis B surface antigen by chromatography on agarose containing aminoalkyl residues |
| IL49752A (en) * | 1975-07-09 | 1979-07-25 | Kabi Ab | Compositions having affinity for hepatitis virus and method for hepatitis virus removal or concentration |
-
1976
- 1976-03-18 SE SE7603386A patent/SE420977B/xx unknown
-
1977
- 1977-02-17 CA CA271,971A patent/CA1073815A/en not_active Expired
- 1977-03-11 FR FR7707329A patent/FR2344629A1/fr active Granted
- 1977-03-14 BE BE175747A patent/BE852416A/xx unknown
- 1977-03-15 JP JP2853377A patent/JPS52114018A/ja active Pending
- 1977-03-15 NL NL7702784A patent/NL7702784A/xx not_active Application Discontinuation
- 1977-03-15 US US05/777,670 patent/US4138287A/en not_active Expired - Lifetime
- 1977-03-16 AU AU23313/77A patent/AU506385B2/en not_active Expired
- 1977-03-17 DE DE19772711773 patent/DE2711773A1/de not_active Withdrawn
- 1977-03-17 GB GB11415/77A patent/GB1511997A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008039136A1 (en) * | 2006-09-29 | 2008-04-03 | Ge Healthcare Bio-Sciences Ab | Separation matrix for viral purification |
| US8481298B2 (en) | 2006-09-29 | 2013-07-09 | Ge Healthcare Bio-Sciences Ab | Separation matrix for viral purification |
Also Published As
| Publication number | Publication date |
|---|---|
| AU506385B2 (en) | 1979-12-20 |
| SE7603386L (sv) | 1977-09-19 |
| JPS52114018A (en) | 1977-09-24 |
| US4138287A (en) | 1979-02-06 |
| NL7702784A (nl) | 1977-09-20 |
| BE852416A (fr) | 1977-07-01 |
| SE420977B (sv) | 1981-11-16 |
| FR2344629A1 (fr) | 1977-10-14 |
| AU2331377A (en) | 1978-09-21 |
| FR2344629B1 (US08188275-20120529-C00054.png) | 1983-07-18 |
| DE2711773A1 (de) | 1977-09-22 |
| CA1073815A (en) | 1980-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |