GB1506640A - Salts of s-adenosyl-l-methionine - Google Patents
Salts of s-adenosyl-l-methionineInfo
- Publication number
- GB1506640A GB1506640A GB28984/75A GB2898475A GB1506640A GB 1506640 A GB1506640 A GB 1506640A GB 28984/75 A GB28984/75 A GB 28984/75A GB 2898475 A GB2898475 A GB 2898475A GB 1506640 A GB1506640 A GB 1506640A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salts
- acid
- sam
- iii
- precipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical class O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title abstract 8
- 150000003839 salts Chemical class 0.000 title abstract 7
- 239000002244 precipitate Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 230000000926 neurological effect Effects 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
- 235000011149 sulphuric acid Nutrition 0.000 abstract 2
- 239000001117 sulphuric acid Substances 0.000 abstract 2
- OVFUUSPKWADLNJ-UHFFFAOYSA-N 5-methyl-4-nitro-2-(4-nitrophenyl)-4h-pyrazol-3-one Chemical compound O=C1C([N+]([O-])=O)C(C)=NN1C1=CC=C([N+]([O-])=O)C=C1 OVFUUSPKWADLNJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000036487 Arthropathies Diseases 0.000 abstract 1
- 208000012659 Joint disease Diseases 0.000 abstract 1
- 206010041347 Somnambulism Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 230000003001 depressive effect Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2512874 | 1974-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1506640A true GB1506640A (en) | 1978-04-05 |
Family
ID=11215784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28984/75A Expired GB1506640A (en) | 1974-07-12 | 1975-07-10 | Salts of s-adenosyl-l-methionine |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4057686A (OSRAM) |
| JP (1) | JPS51125717A (OSRAM) |
| AR (1) | AR221676A1 (OSRAM) |
| AT (1) | AT366064B (OSRAM) |
| AU (1) | AU498365B2 (OSRAM) |
| BE (1) | BE831310A (OSRAM) |
| CA (1) | CA1057681A (OSRAM) |
| CH (1) | CH606085A5 (OSRAM) |
| DD (1) | DD118643A5 (OSRAM) |
| DE (1) | DE2530898A1 (OSRAM) |
| DK (1) | DK144946C (OSRAM) |
| ES (1) | ES439316A1 (OSRAM) |
| FI (1) | FI63037C (OSRAM) |
| FR (1) | FR2277590A1 (OSRAM) |
| GB (1) | GB1506640A (OSRAM) |
| HU (1) | HU170264B (OSRAM) |
| IE (1) | IE41421B1 (OSRAM) |
| IL (1) | IL47656A (OSRAM) |
| NL (1) | NL171987C (OSRAM) |
| NO (1) | NO142175C (OSRAM) |
| NZ (1) | NZ178014A (OSRAM) |
| PL (1) | PL94268B1 (OSRAM) |
| RO (1) | RO77525A (OSRAM) |
| SE (1) | SE420204B (OSRAM) |
| SU (1) | SU676169A3 (OSRAM) |
| YU (1) | YU39271B (OSRAM) |
| ZA (1) | ZA754167B (OSRAM) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5428808A (en) * | 1977-08-03 | 1979-03-03 | Yamasa Shoyu Co Ltd | Composition containing s-adenoyl-l-methionine and its preparation |
| GB2001976B (en) * | 1977-08-03 | 1982-03-10 | Yamasa Shoyu Kk | S-adenosyl-l-methionine compositions and production thereof |
| JPS5596099A (en) * | 1979-01-12 | 1980-07-21 | Tanabe Seiyaku Co Ltd | Production of s-adenosyl-l-methionine using enzyme |
| GB2064523B (en) * | 1979-12-04 | 1983-06-29 | Kanegafuchi Chemical Ind | Stable composition of s-adenosyl-l-methionine |
| IT1137892B (it) * | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1137640B (it) * | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1139974B (it) * | 1981-09-11 | 1986-09-24 | Bioresearch Srl | Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo |
| US4419358A (en) * | 1981-11-12 | 1983-12-06 | Mead Johnson & Company | Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it |
| IT1169772B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Composizioni terapeutiche per uso orale contenenti sali stabili della s-adenosil-l-metionina |
| IT1169773B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Processo per la produzione di sali stabili della solfo-adenosil-l-metionina |
| IT1169774B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina |
| IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
| IT1177373B (it) * | 1984-12-06 | 1987-08-26 | Bioresearch Spa | Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica |
| IT1200589B (it) * | 1985-02-14 | 1989-01-27 | Gibipharma Spa | Derivati naturali attivita farmagologica |
| US4962451A (en) * | 1985-11-07 | 1990-10-09 | International Business Machines Corporation | Cache-effective sort string generation method |
| JPH03501970A (ja) * | 1987-10-09 | 1991-05-09 | ザッピア ヴィンセンツォ | Ｓ‐アデノシル‐ｌ‐メチオニン（ｓａｍ）のアシル化タウリン誘導体との親油性塩 |
| FR2623396B1 (fr) * | 1987-11-25 | 1990-03-30 | Sanofi Sa | Utilisation de l'ademetionine contre le vieillissement de la peau |
| IT1229477B (it) * | 1989-03-13 | 1991-09-03 | Bioresearch Spa | Impiego di 5' deossi - 5' metiltioadenosina, s adenosilmetionina e dei loro sali per la preparazione di composizioni farmaceutiche atte a ridurre la seborrea e composizioni farmaceutiche relative |
| JPH02290896A (ja) * | 1989-04-28 | 1990-11-30 | Fuji Kagaku Kogyo Kk | 新規なｓ―アデノシルメチオニン誘導体 |
| JPH03123514U (OSRAM) * | 1990-03-27 | 1991-12-16 | ||
| US6399093B1 (en) | 1999-05-19 | 2002-06-04 | Advanced Medical Instruments | Method and composition to treat musculoskeletal disorders |
| US6635615B1 (en) * | 1999-11-17 | 2003-10-21 | Rolland F. Hebert | Stable salts of S-adenosyl-l-methionine |
| DE10022856A1 (de) * | 2000-05-10 | 2001-11-15 | Basf Ag | Therapeutische Kombination von Liponsäure und C1-Donoren zur Behandlung von Störungen des Zentralen Nervensystems |
| US6759395B2 (en) | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
| FR2823211A1 (fr) * | 2001-04-10 | 2002-10-11 | Virbac Sa | Composition a base d'un polyphosphate de s-adenosyl-l-methionine et utilisations d'un tel polyphosphate |
| US6649753B2 (en) | 2001-06-07 | 2003-11-18 | Orchid Chemicals & Pharmaceuticals Ltd. | Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation |
| US6881837B2 (en) | 2001-06-07 | 2005-04-19 | Orchid Chemicals & Pharmaceuticals Ltd. | Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer |
| WO2002102823A1 (en) * | 2001-06-14 | 2002-12-27 | Orchid Chemicals & Pharmaceuticals Limited | Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation |
| US20050272687A1 (en) * | 2004-06-08 | 2005-12-08 | Hebert Rolland F | Stable S-adenosyl-l-methionine |
| EP1812454A2 (en) | 2004-06-23 | 2007-08-01 | Orchid Chemicals and Pharmaceuticals Ltd | Chemical synthesis of s-adenosyl-l-methionine with enrichment of (s,s)-isomer |
| WO2006079212A1 (en) | 2005-01-26 | 2006-08-03 | Diamedica Inc. | Use of s-adenosylmethionme, vitamin e, and vitamin c for the treatment of oxidative liver injury or insulin resistance |
| FR2884421B1 (fr) | 2005-04-15 | 2007-08-10 | Virbac Sa | Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie |
| EP1874937A2 (en) * | 2005-04-20 | 2008-01-09 | BASF Plant Science GmbH | Expression cassettes for seed-preferential expression in plants |
| US20090012036A1 (en) * | 2005-05-24 | 2009-01-08 | Hebert Rolland F | Stable S-adenosyl-L-methionine |
| ITMI20060629A1 (it) * | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
| CN101437934B (zh) | 2006-05-10 | 2013-03-20 | 三菱瓦斯化学株式会社 | 含s-腺苷-l-甲硫氨酸的干燥酵母的制备方法以及口服用组合物 |
| US20090088404A1 (en) * | 2007-01-31 | 2009-04-02 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| CN101677543A (zh) * | 2007-01-31 | 2010-03-24 | 甲基化物科学国际有限公司 | S-腺苷甲硫氨酸的延时释放药物制剂 |
| US20090197824A1 (en) * | 2008-01-31 | 2009-08-06 | Methylation Sciences International Srl | Extended Release Pharmaceutical Formulations of S-Adenosylmethionine |
| ITMI20071374A1 (it) * | 2007-07-10 | 2009-01-11 | Gnosis Spa | Sali stabili di s-adenosilmetionina e processo per il loro ottenimento. |
| US20100004191A1 (en) * | 2008-07-01 | 2010-01-07 | Rolland F Hebert | Compositions of S-adenosyl-L-methionine. |
| EP2193787A1 (en) * | 2008-12-02 | 2010-06-09 | Giorgio Stramentinoli | Formulations for systemic buccal delivery comprising s-adenosylmethionine, their preparation and use |
| US8329208B2 (en) | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
| US20110027342A1 (en) * | 2009-07-28 | 2011-02-03 | Msi Methylation Sciences, Inc. | S-adenosylmethionine formulations with enhanced bioavailability |
| CN103906521A (zh) | 2011-04-15 | 2014-07-02 | 塞玛尔有限公司 | S-腺苷甲硫氨酸、维生素e和维生素c在预防和治疗心血管功能障碍中的应用 |
| CN102321136B (zh) * | 2011-09-19 | 2014-10-22 | 北京化工大学 | S-腺苷-l-甲硫氨酸对甲苯磺酸硫酸双盐的制备方法 |
| CA2888302C (en) | 2012-10-17 | 2016-05-31 | Methylation Sciences International Srl | Compositions comprising s-adenosylmethionine and a gallic acid ester |
| US9534010B2 (en) | 2013-01-16 | 2017-01-03 | Hebert Sam-E Llc | Stable indole-3-propionate salts of S-adenosyl-L-methionine |
| RU2537556C1 (ru) * | 2013-07-30 | 2015-01-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ получения соли адеметионина с хондроитинсульфокислотой |
| US12239623B2 (en) | 2023-05-15 | 2025-03-04 | Bonafide Health, Llc | Sleep-improving compositions and methods of use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1803978C2 (de) * | 1968-10-18 | 1985-05-02 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin |
| IE37913B1 (en) * | 1972-08-02 | 1977-11-09 | Bioresearch Sas | Salt of s-adenosyl-l-methionine |
| IE39517B1 (en) * | 1973-06-27 | 1978-10-25 | Bioresearch Sas | Double salts of s-adenosyl-l-methhionine |
-
1975
- 1975-01-01 AR AR259529A patent/AR221676A1/es active
- 1975-06-30 ZA ZA00754167A patent/ZA754167B/xx unknown
- 1975-06-30 IE IE1448/75A patent/IE41421B1/en unknown
- 1975-07-02 FR FR7520778A patent/FR2277590A1/fr active Granted
- 1975-07-03 FI FI751946A patent/FI63037C/fi not_active IP Right Cessation
- 1975-07-03 NZ NZ178014A patent/NZ178014A/xx unknown
- 1975-07-07 IL IL47656A patent/IL47656A/xx unknown
- 1975-07-07 AT AT0521275A patent/AT366064B/de not_active IP Right Cessation
- 1975-07-09 US US05/594,601 patent/US4057686A/en not_active Expired - Lifetime
- 1975-07-09 YU YU1744/75A patent/YU39271B/xx unknown
- 1975-07-09 HU HUEE2357A patent/HU170264B/hu unknown
- 1975-07-10 GB GB28984/75A patent/GB1506640A/en not_active Expired
- 1975-07-10 CA CA231,185A patent/CA1057681A/en not_active Expired
- 1975-07-10 DE DE19752530898 patent/DE2530898A1/de active Granted
- 1975-07-11 SE SE7507966A patent/SE420204B/xx not_active IP Right Cessation
- 1975-07-11 DK DK315375A patent/DK144946C/da not_active IP Right Cessation
- 1975-07-11 ES ES439316A patent/ES439316A1/es not_active Expired
- 1975-07-11 SU SU752152821A patent/SU676169A3/ru active
- 1975-07-11 RO RO7582833A patent/RO77525A/ro unknown
- 1975-07-11 JP JP50085200A patent/JPS51125717A/ja active Granted
- 1975-07-11 NO NO752499A patent/NO142175C/no unknown
- 1975-07-11 AU AU82959/75A patent/AU498365B2/en not_active Expired
- 1975-07-11 BE BE158248A patent/BE831310A/xx not_active IP Right Cessation
- 1975-07-11 CH CH913575A patent/CH606085A5/xx not_active IP Right Cessation
- 1975-07-11 DD DD187262A patent/DD118643A5/xx unknown
- 1975-07-11 NL NLAANVRAGE7508316,A patent/NL171987C/xx not_active IP Right Cessation
- 1975-07-12 PL PL1975182042A patent/PL94268B1/pl unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 416 | Proceeding under section 16 patents act 1949 | ||
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19950709 |