GB1473733A - Pseudotrisaccharides and methods for their production - Google Patents

Pseudotrisaccharides and methods for their production

Info

Publication number
GB1473733A
GB1473733A GB3396874A GB3396874A GB1473733A GB 1473733 A GB1473733 A GB 1473733A GB 3396874 A GB3396874 A GB 3396874A GB 3396874 A GB3396874 A GB 3396874A GB 1473733 A GB1473733 A GB 1473733A
Authority
GB
United Kingdom
Prior art keywords
gentamicin
antibiotic
mutamicin
diaminocyclitols
aminoglycosyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3396874A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,586 external-priority patent/US4029882A/en
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of GB1473733A publication Critical patent/GB1473733A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
GB3396874A 1973-08-06 1974-08-01 Pseudotrisaccharides and methods for their production Expired GB1473733A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38575173A 1973-08-06 1973-08-06
US45260074A 1974-03-19 1974-03-19
US05/452,586 US4029882A (en) 1974-03-19 1974-03-19 Selective acylation of the C-1 amino group of aminoglycoside antibiotics

Publications (1)

Publication Number Publication Date
GB1473733A true GB1473733A (en) 1977-05-18

Family

ID=27409729

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3396874A Expired GB1473733A (en) 1973-08-06 1974-08-01 Pseudotrisaccharides and methods for their production

Country Status (20)

Country Link
AR (1) AR215834A1 (enExample)
BE (1) BE818431A (enExample)
BG (1) BG25804A3 (enExample)
CH (1) CH606076A5 (enExample)
CY (1) CY1018A (enExample)
DD (1) DD119037A5 (enExample)
DE (2) DE2437160C3 (enExample)
DK (1) DK146298C (enExample)
FI (1) FI62100C (enExample)
FR (1) FR2240015B1 (enExample)
GB (1) GB1473733A (enExample)
HK (1) HK55179A (enExample)
IE (1) IE40437B1 (enExample)
IL (1) IL45385A (enExample)
KE (1) KE2981A (enExample)
LU (1) LU70661A1 (enExample)
MY (1) MY8000090A (enExample)
NL (1) NL171587C (enExample)
NO (1) NO139483C (enExample)
SE (1) SE424994B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2293383B (en) * 1993-04-23 1997-02-26 Jiangsu Inst Microbiology Method of preparing 1-N-ethylgentamicin derivatives
CN101575311B (zh) * 2009-06-19 2011-05-04 无锡好芳德药业有限公司 一种制备褪黑素的方法
US8383596B2 (en) 2007-11-21 2013-02-26 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8492354B2 (en) 2009-05-15 2013-07-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524675B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524689B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8653042B2 (en) 2009-05-15 2014-02-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8658606B2 (en) 2009-05-15 2014-02-25 Achaogen, Inc. Antibacterial aminoglycoside analogs

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1464401A (en) * 1974-10-26 1977-02-16 Pfizer Ltd Aminoglycosides
US4217446A (en) 1974-10-26 1980-08-12 Pfizer Inc. ωAmino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics
FR2405266A1 (fr) * 1975-09-08 1979-05-04 Scherico Ltd Nouveaux pseudotrisaccharides, et applications pharmaceutiques de ceux-ci
EP0000057B1 (de) * 1977-06-10 1982-07-14 Bayer Ag Selektiv geschützte 4,6-Di-O-(aminoglycosyl)-1,3-diaminocyclitole
US4282350A (en) * 1977-08-05 1981-08-04 Schering Corporation Selective 3"-N-acylation of 1,3"-di-N-unprotected-poly-N-protected-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols
JPS5492951A (en) * 1977-12-29 1979-07-23 Shionogi & Co Ltd Novel aminoglycoside derivative
JPS5538345A (en) * 1978-09-11 1980-03-17 Shionogi & Co Ltd Novel aminoglycoside derivative
DE2840907A1 (de) * 1978-09-20 1980-04-03 Bayer Ag Selektiv geschuetzte 4,6-di-o-(aminoglykosyl)-1,3-diaminocyclitole
DE2928183A1 (de) * 1979-07-12 1981-01-29 Bayer Ag 1-n-alkylsisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1235311B (de) * 1963-03-25 1967-03-02 Roussel Uclaf Verfahren zur Herstellung von N-Monophenylaethylneomycin B bzw. seinen therapeutisch vertraeglichen Salzen

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2293383B (en) * 1993-04-23 1997-02-26 Jiangsu Inst Microbiology Method of preparing 1-N-ethylgentamicin derivatives
US8822424B2 (en) 2007-11-21 2014-09-02 Achaogen, Inc. Antibacterial aminoglycoside analogs
US11117915B2 (en) 2007-11-21 2021-09-14 Cipla USA, Inc. Antibacterial aminoglycoside analogs
US8383596B2 (en) 2007-11-21 2013-02-26 Achaogen, Inc. Antibacterial aminoglycoside analogs
US9688711B2 (en) 2007-11-21 2017-06-27 Achaogen, Inc. Antibacterial aminoglycoside analogs
US9266919B2 (en) 2007-11-21 2016-02-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8492354B2 (en) 2009-05-15 2013-07-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8658606B2 (en) 2009-05-15 2014-02-25 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8653042B2 (en) 2009-05-15 2014-02-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524689B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524675B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
USRE47741E1 (en) 2009-05-15 2019-11-26 Achaogen, Inc. Antibacterial aminoglycoside analogs
CN101575311B (zh) * 2009-06-19 2011-05-04 无锡好芳德药业有限公司 一种制备褪黑素的方法

Also Published As

Publication number Publication date
BE818431A (fr) 1975-02-03
HK55179A (en) 1979-08-17
IL45385A (en) 1978-10-31
FR2240015A1 (enExample) 1975-03-07
LU70661A1 (enExample) 1975-05-21
DK146298B (da) 1983-08-29
FI62100C (fi) 1982-11-10
NO139483C (no) 1979-03-21
DE2462485A1 (de) 1977-04-21
NL171587C (nl) 1983-04-18
NO139483B (no) 1978-12-11
NL7410363A (nl) 1975-02-10
CY1018A (en) 1979-11-23
DD119037A5 (enExample) 1976-04-05
AU7194274A (en) 1976-02-05
DE2437160B2 (de) 1979-01-04
FR2240015B1 (enExample) 1978-08-18
SE7409946L (enExample) 1975-02-07
NO742787L (enExample) 1975-03-03
CH606076A5 (enExample) 1978-10-13
DE2437160C3 (de) 1979-08-30
SE424994B (sv) 1982-08-23
DE2437160A1 (de) 1975-02-20
MY8000090A (en) 1980-12-31
DK412474A (enExample) 1975-04-01
DE2462485C2 (de) 1987-04-09
DK146298C (da) 1984-02-06
BG25804A3 (bg) 1978-12-12
NL171587B (nl) 1982-11-16
KE2981A (en) 1979-07-20
IE40437L (en) 1975-02-06
IE40437B1 (en) 1979-06-06
FI230474A7 (enExample) 1975-02-07
AR215834A1 (es) 1979-11-15
FI62100B (fi) 1982-07-30
IL45385A0 (en) 1974-11-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19940731