GB1472525A - Olefinic derivatives of amino acids - Google Patents
Olefinic derivatives of amino acidsInfo
- Publication number
- GB1472525A GB1472525A GB285676A GB285676A GB1472525A GB 1472525 A GB1472525 A GB 1472525A GB 285676 A GB285676 A GB 285676A GB 285676 A GB285676 A GB 285676A GB 1472525 A GB1472525 A GB 1472525A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- hydrogen
- lower alkyl
- straight
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003951 lactams Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- ZDQWVKDDJDIVAL-UHFFFAOYSA-N catecholborane Chemical compound C1=CC=C2O[B]OC2=C1 ZDQWVKDDJDIVAL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000012299 nitrogen atmosphere Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/559,544 US3960927A (en) | 1975-03-18 | 1975-03-18 | Olefinic derivatives of amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1472525A true GB1472525A (en) | 1977-05-04 |
Family
ID=24233995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB285676A Expired GB1472525A (en) | 1975-03-18 | 1976-01-26 | Olefinic derivatives of amino acids |
Country Status (20)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0094886A1 (en) * | 1982-05-17 | 1983-11-23 | Merrell Toraude Et Compagnie | Aminoalkadiene derivative |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4039549A (en) * | 1975-03-18 | 1977-08-02 | Merrell Toraude Et Compagnie | Olefinic derivatives of amino acids |
| US4041041A (en) * | 1975-03-18 | 1977-08-09 | Merrell Toraude Et Compagnie | Acetylene derivatives of amino acids |
| CA1157030A (en) * | 1977-07-01 | 1983-11-15 | Brian W. Metcalf | .alpha.-VINYL AMINO ACIDS |
| CA1121375A (en) * | 1977-07-01 | 1982-04-06 | Brian W. Metcalf | Derivatives of amines and amino acids |
| US4139563A (en) * | 1977-07-01 | 1979-02-13 | Merrell Toraude Et Compagnie | α-ACETYLENIC DERIVATIVES OF AMINES |
| US4147873A (en) * | 1977-07-01 | 1979-04-03 | Merrell Toraude Et Compagnie | α-Vinyl derivatives of α-amino acids |
| US4326071A (en) * | 1977-09-28 | 1982-04-20 | Merrell Toraude Et Compagnie | Halomethyl derivatives of gamma-aminobutyric acid and related compounds |
| US4187316A (en) * | 1978-01-12 | 1980-02-05 | Merrell Toraude Et Compagnie | Substituted 1,5-cyclohexadiene carboxylic acid derivatives |
| US4178463A (en) * | 1978-01-30 | 1979-12-11 | Merrell Toraude Et Compagnie | Process for making 4-aminohex-5-enoic acid |
| US4254284A (en) * | 1978-01-30 | 1981-03-03 | Merrell Toraude Et Compagnie | Process for preparing 4-aminohex-5-ynoic acid |
| US5147868A (en) * | 1978-07-24 | 1992-09-15 | Merck & Co., Inc. | Thienamycin renal peptidase inhibitors |
| US4880793A (en) * | 1978-07-24 | 1989-11-14 | Merck & Co., Inc. | Combination of thienamycin-type antibiotics with dipeptidase inhibitors |
| US4323704A (en) * | 1979-06-25 | 1982-04-06 | Merrell Toraude Et Compagnie | αAcetylene and α-vinyl derivatives of amino acids |
| US4539208A (en) * | 1980-09-17 | 1985-09-03 | Merck & Co., Inc. | Combination of thienamycin-type antibiotics with dipeptidase inhibitors |
| US4372974A (en) * | 1980-06-25 | 1983-02-08 | New York University | Anticonvulsive compositions and method of treating convulsive disorders |
| GB2133002B (en) * | 1982-12-30 | 1986-01-29 | Merrell Toraude & Co | Process for preparing 4-amino-5-hexenoic acid |
| GB8311804D0 (en) * | 1983-04-29 | 1983-06-02 | Merrell Toraude & Co | Treatment of seizure disorders and pharmaceutical compositions |
| DK335784A (da) * | 1983-07-07 | 1985-01-08 | Syntex Inc | Gamma-allenyl-gamma-aminosmoersyrederivater |
| US4668703A (en) * | 1983-07-07 | 1987-05-26 | Syntex (U.S.A.) Inc. | γ-allenyl-γ-aminobutyric acids |
| US4661510A (en) * | 1983-08-17 | 1987-04-28 | Syntex (U.S.A.) Inc. | α-allenic-α-amino acids as enzyme inhibitors |
| US4588825A (en) * | 1983-10-11 | 1986-05-13 | Merrell Dow Pharmaceuticals Inc. | Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furancarboxylic acid |
| US4632994A (en) * | 1983-11-04 | 1986-12-30 | Gruppo Lepetit S.P.A. | Process for decomposing N-oxide derivatives producing 5-vinyl-2-pyrrolidones |
| JPS6137389U (ja) * | 1984-08-09 | 1986-03-08 | 永大産業株式会社 | 家具用の戸 |
| DE3536146A1 (de) * | 1985-10-10 | 1987-04-16 | Degussa | Verfahren zur enantioselektiven herstellung von (alpha)-vinyl-(alpha)-aminocarbonsaeuren |
| US4727062A (en) * | 1986-03-17 | 1988-02-23 | Merck & Co., Inc. | 3-Halovinylglycine antibacterial agents |
| US4806680A (en) * | 1986-03-17 | 1989-02-21 | Merck & Co., Inc. | 3-halovinylglycine antibacterial agents |
| CA2028782C (en) * | 1989-11-07 | 2003-10-14 | Christian T. Goralski | Process for the production of vinyl-gaba |
| US5208345A (en) * | 1990-12-17 | 1993-05-04 | Merrell Dow Pharmaceuticals Inc. | Process for the production of (S)-vinyl and allenyl gaba |
| AU644919B2 (en) * | 1990-12-17 | 1993-12-23 | Aventisub Ii Inc. | Process for the production of (S)-vinyl and allenyl gaba |
| EP0546230A1 (en) * | 1991-12-10 | 1993-06-16 | Merrell Dow Pharmaceuticals Inc. | Novel process for preparing 4-amino-5-hexenoic acid |
| US5705660A (en) * | 1994-08-22 | 1998-01-06 | Board Of Regents, University Of Nebraska-Lincoln | Method for the synthesis of α-oxiranyl amino acids |
| US7098206B2 (en) * | 1998-01-21 | 2006-08-29 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| US6998400B2 (en) * | 1998-01-22 | 2006-02-14 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| WO1999038504A1 (en) | 1998-01-29 | 1999-08-05 | Sepracor Inc. | Pharmaceutical uses of optically pure (-)-bupropion |
| JP2002501891A (ja) | 1998-01-29 | 2002-01-22 | セプラコア インコーポレーテッド | 光学的に純粋な（＋）−ビュープロピオンの医薬用途 |
| US6541520B1 (en) | 1998-08-05 | 2003-04-01 | Brookhaven Science Associates | Treatment of addiction and addiction-related behavior |
| US6855820B2 (en) | 1999-01-20 | 2005-02-15 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| US6734213B2 (en) | 1999-01-20 | 2004-05-11 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| US6337328B1 (en) * | 1999-03-01 | 2002-01-08 | Sepracor, Inc. | Bupropion metabolites and methods of use |
| US6342496B1 (en) * | 1999-03-01 | 2002-01-29 | Sepracor Inc. | Bupropion metabolites and methods of use |
| AP2001002359A0 (en) | 2000-11-30 | 2001-12-31 | Pfizer Prod Inc | Combination of gaba agonists and aldose reductase inhibitors. |
| EA200300432A1 (ru) | 2000-11-30 | 2003-10-30 | Пфайзер Продактс Инк. | Комбинация гамк-агонистов и ингибиторов сорбитолдегидрогеназы |
| BRPI0410271A (pt) * | 2003-05-16 | 2006-05-16 | Pfizer Prod Inc | combinações terapêuticas de antipsicóticos atìpicos com moduladores de gaba, anticonvulsivantes ou benzodiazepinas |
| PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
| WO2005082372A1 (en) * | 2004-01-29 | 2005-09-09 | Pfizer Products Inc. | COMBINATION OF γ-AMINOBUTYRIC ACID MODULATORS AND 5-HT 1B RECEPTOR ANTAGONISTS |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249435A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| BRPI0716604A2 (pt) | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| CA2679741A1 (en) * | 2007-03-15 | 2008-09-18 | Sun Pharma Advanced Research Company Ltd. | Novel prodrugs |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2537827B1 (en) | 2011-06-24 | 2014-06-11 | Targeon SAS | Process for preparing 4-amino-5-hexenoic acid from succinimide |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2460708A (en) * | 1946-03-22 | 1949-02-01 | Merck & Co Inc | Process for making acetamido dimethylacrylic acid |
| US2531595A (en) * | 1949-06-09 | 1950-11-28 | Sterling Drug Inc | Preparation of alpha-acylamino-alpha-substituted-acetic acids |
| US2588969A (en) * | 1949-11-26 | 1952-03-11 | Eastman Kodak Co | Certain acylamino-acrylates and-crotonates as insecticides |
| US3223729A (en) * | 1962-06-06 | 1965-12-14 | Sterling Drug Inc | 3-allylhydantoic acid |
-
1975
- 1975-03-18 US US05/559,544 patent/US3960927A/en not_active Expired - Lifetime
-
1976
- 1976-01-23 IE IE136/76A patent/IE42410B1/en unknown
- 1976-01-26 NO NO760234A patent/NO146428C/no unknown
- 1976-01-26 ZA ZA411A patent/ZA76411B/xx unknown
- 1976-01-26 NZ NZ179834A patent/NZ179834A/en unknown
- 1976-01-26 GB GB285676A patent/GB1472525A/en not_active Expired
- 1976-01-27 IL IL48912A patent/IL48912A/xx unknown
- 1976-01-27 DK DK31476A patent/DK145339C/da not_active IP Right Cessation
- 1976-02-02 PT PT64761A patent/PT64761B/pt unknown
- 1976-02-03 PH PH18044A patent/PH12100A/en unknown
- 1976-02-04 SE SE7601205A patent/SE442295B/xx not_active IP Right Cessation
- 1976-02-04 NL NLAANVRAGE7601116,A patent/NL187161C/xx active Protection Beyond IP Right Term
- 1976-02-17 CA CA245,927A patent/CA1077487A/en not_active Expired
- 1976-02-25 DE DE2607620A patent/DE2607620C2/de not_active Expired
- 1976-02-26 JP JP51019522A patent/JPS593988B2/ja not_active Expired
- 1976-02-27 CH CH245476A patent/CH631696A5/de active Protection Beyond IP Right Term
- 1976-02-28 ES ES445659A patent/ES445659A1/es not_active Expired
- 1976-03-02 MX MX7665U patent/MX4654E/es unknown
- 1976-03-16 FR FR7607547A patent/FR2304329A1/fr active Granted
- 1976-03-17 BE BE165245A patent/BE839657A/xx not_active IP Right Cessation
-
1993
- 1993-06-30 NL NL930125C patent/NL930125I2/nl unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0094886A1 (en) * | 1982-05-17 | 1983-11-23 | Merrell Toraude Et Compagnie | Aminoalkadiene derivative |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| CTFF | Supplementary protection certificate filed |
Free format text: SPC/GB93/119, 930629 |
|
| CTFG | Supplementary protection certificate granted |
Free format text: SPC/GB93/119, 931119, EXPIRES:20010125 |
|
| CTFE | Supplementary protection certificate entered into force |
Free format text: SPC/GB93/119, 960126, EXPIRES:20010125 |
|
| PE20 | Patent expired after termination of 20 years |
Effective date: 19960125 |
|
| SPCE | Supplementary protection certificate expired |
Free format text: SPC/GB93/119, 20010125 |