GB1458293A - 3-halo cephalosporins - Google Patents
3-halo cephalosporinsInfo
- Publication number
- GB1458293A GB1458293A GB809674A GB809674A GB1458293A GB 1458293 A GB1458293 A GB 1458293A GB 809674 A GB809674 A GB 809674A GB 809674 A GB809674 A GB 809674A GB 1458293 A GB1458293 A GB 1458293A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- thienyl
- amino
- methyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 -halo cephalosporins Chemical class 0.000 title abstract 12
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 2
- YYSCKUIUUOYNNB-NQPNHJOESA-N (6R)-7-amino-3-methylidene-5-thia-1-azabicyclo[4.2.0]octan-8-one Chemical class C=C1CS[C@H]2N(C1)C(C2N)=O YYSCKUIUUOYNNB-NQPNHJOESA-N 0.000 abstract 1
- 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000006181 N-acylation Effects 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001782 cephems Chemical class 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 230000006196 deacetylation Effects 0.000 abstract 1
- 238000003381 deacetylation reaction Methods 0.000 abstract 1
- 238000005947 deacylation reaction Methods 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000006331 halo benzoyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000006502 nitrobenzyl group Chemical group 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33541473A | 1973-02-23 | 1973-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1458293A true GB1458293A (en) | 1976-12-15 |
Family
ID=23311677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB809674A Expired GB1458293A (en) | 1973-02-23 | 1974-02-22 | 3-halo cephalosporins |
Country Status (34)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT342197B (de) * | 1975-02-20 | 1978-03-28 | Ciba Geigy Ag | Neues verfahren zur herstellung von 3-cephemverbindungen |
| CH622802A5 (enExample) * | 1975-08-20 | 1981-04-30 | Ciba Geigy Ag | |
| IE45158B1 (en) * | 1976-08-16 | 1982-06-30 | Lilly Co Eli | 3-chloro-cephem synthesis |
| PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
| JPS62112053U (enExample) * | 1985-12-27 | 1987-07-16 | ||
| IT1255458B (it) * | 1992-05-11 | 1995-11-02 | Col Marco Da | Procedimento per la preparazione di derivati beta-lattamici alogenati |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2143211B1 (enExample) * | 1971-06-24 | 1975-10-31 | Fujisawa Pharmaceutical Co |
-
1974
- 1974-01-01 AR AR256545A patent/AR208068A1/es active
- 1974-02-21 AT AT142474A patent/AT333952B/de not_active IP Right Cessation
- 1974-02-22 ES ES423532A patent/ES423532A1/es not_active Expired
- 1974-02-22 CA CA193,238A patent/CA1032532A/en not_active Expired
- 1974-02-22 YU YU0463/74A patent/YU36971B/xx unknown
- 1974-02-22 HU HUEI527A patent/HU167749B/hu unknown
- 1974-02-22 ZM ZM36/74A patent/ZM3674A1/xx unknown
- 1974-02-22 MW MW5/74*UA patent/MW574A1/xx unknown
- 1974-02-22 FI FI526/74A patent/FI63240C/fi active
- 1974-02-22 DE DE2408686A patent/DE2408686C2/de not_active Expired
- 1974-02-22 AR AR252494A patent/AR200908A1/es active
- 1974-02-22 BE BE1005740A patent/BE811494A/xx not_active IP Right Cessation
- 1974-02-22 GB GB809674A patent/GB1458293A/en not_active Expired
- 1974-02-22 BG BG025871A patent/BG22404A3/xx unknown
- 1974-02-22 SE SE7402414A patent/SE411211B/xx not_active IP Right Cessation
- 1974-02-22 CY CY1042A patent/CY1042A/xx unknown
- 1974-02-22 IL IL44263A patent/IL44263A/en unknown
- 1974-02-22 FR FR7406154A patent/FR2218878B1/fr not_active Expired
- 1974-02-22 NO NO740607A patent/NO148376C/no unknown
- 1974-02-22 ZA ZA00741190A patent/ZA741190B/xx unknown
- 1974-02-22 DD DD176752A patent/DD110277A5/xx unknown
- 1974-02-22 GT GT197432132A patent/GT197432132A/es unknown
- 1974-02-22 IE IE00357/74A patent/IE38916B1/xx unknown
- 1974-02-22 NL NLAANVRAGE7402486,A patent/NL181010C/xx not_active IP Right Cessation
- 1974-02-22 BR BR1385/74A patent/BR7401385D0/pt unknown
- 1974-02-23 OA OA55127A patent/OA04688A/xx unknown
- 1974-02-23 PL PL1974169033A patent/PL88714B1/pl unknown
- 1974-02-23 JP JP49021871A patent/JPS612677B2/ja not_active Expired
- 1974-02-23 RO RO7477795A patent/RO64595A/ro unknown
- 1974-02-25 CH CH265474A patent/CH594686A5/xx not_active IP Right Cessation
- 1974-02-25 CS CS741377A patent/CS189625B2/cs unknown
- 1974-11-15 AR AR256546A patent/AR201709A1/es active
-
1977
- 1977-02-11 PH PH19444A patent/PH14014A/en unknown
-
1979
- 1979-08-10 NO NO792609A patent/NO792609L/no unknown
-
1980
- 1980-02-27 KE KE3026A patent/KE3026A/xx unknown
- 1980-04-11 YU YU0998/80A patent/YU37347B/xx unknown
- 1980-04-17 HK HK199/80A patent/HK19980A/xx unknown
-
1981
- 1981-02-20 JP JP2533181A patent/JPS56138193A/ja active Granted
- 1981-02-20 JP JP2533381A patent/JPS56138195A/ja active Granted
- 1981-02-20 JP JP2533281A patent/JPS56138194A/ja active Granted
- 1981-12-30 MY MY23/81A patent/MY8100023A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19940221 |