GB1443680A - Manufacture of hydroxylated chloesterol derivatives - Google Patents

Manufacture of hydroxylated chloesterol derivatives

Info

Publication number
GB1443680A
GB1443680A GB4872274A GB4872274A GB1443680A GB 1443680 A GB1443680 A GB 1443680A GB 4872274 A GB4872274 A GB 4872274A GB 4872274 A GB4872274 A GB 4872274A GB 1443680 A GB1443680 A GB 1443680A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
cholestan
cholestane
dihydroxy
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4872274A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1443680A publication Critical patent/GB1443680A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
GB4872274A 1973-11-12 1974-11-11 Manufacture of hydroxylated chloesterol derivatives Expired GB1443680A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US415186A US3887545A (en) 1973-11-12 1973-11-12 Synthesis of 1{60 -hydroxylated cholesterol derivatives

Publications (1)

Publication Number Publication Date
GB1443680A true GB1443680A (en) 1976-07-21

Family

ID=23644712

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4872274A Expired GB1443680A (en) 1973-11-12 1974-11-11 Manufacture of hydroxylated chloesterol derivatives

Country Status (9)

Country Link
US (1) US3887545A (https=)
JP (1) JPS5438098B2 (https=)
AT (1) AT342793B (https=)
BE (1) BE821983A (https=)
CH (1) CH599247A5 (https=)
DE (1) DE2453648C3 (https=)
FR (1) FR2250764B1 (https=)
GB (1) GB1443680A (https=)
NL (1) NL7414675A (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
US4264512A (en) * 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
JPS603045B2 (ja) * 1976-04-19 1985-01-25 中外製薬株式会社 １α―ヒドロキシビタミンＤ類軟カプセルの製造方法
US4098801A (en) * 1977-01-26 1978-07-04 Hoffmann-La Roche Inc. Synthesis of 1α-hydroxylated derivatives of cholesterol
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
US5952317A (en) * 1995-09-21 1999-09-14 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
US5976784A (en) * 1996-09-20 1999-11-02 Wisconsin Alumni Research Foundation Calcitriol derivatives and their uses
HUP9904616A3 (en) 1996-12-20 2001-02-28 Novo Nordisk As Meiosis regulating cholestane-derivatives
IL146223A0 (en) * 1999-04-30 2002-07-25 Arch Dev Corp Steroid derivatives
JP2005508281A (ja) * 2001-02-08 2005-03-31 ザ ユニバーシティー オブ シカゴ ステロイド誘導体
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
AU2003228485A1 (en) * 2002-04-12 2003-10-27 The University Of Chicago Farnesoid x-activated receptor agonists
US7897588B2 (en) * 2002-08-29 2011-03-01 The Regents Of The University Of California Agents and methods for enhancing bone formation
US9532994B2 (en) * 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
US20070032464A1 (en) * 2004-10-08 2007-02-08 Shutsung Liao Methods of treating cancers
DE502006002752D1 (de) * 2005-04-23 2009-03-19 Ixetic Mac Gmbh Axialkolbenmaschine
CA2621157A1 (en) * 2005-09-02 2007-03-08 The Regents Of The University Of California Osteogenic and anti-adipogenic oxysterols
US9670244B2 (en) * 2006-02-27 2017-06-06 The Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
US20100048944A1 (en) * 2006-07-19 2010-02-25 Farhad Parhami Interactions of hedgehog and liver x receptor signaling pathways
AU2007339325A1 (en) 2006-12-19 2008-07-10 The Regents Of The University Of California Inhibition of PPAR gamma expression by specific osteogenic oxysterols
WO2009073186A1 (en) * 2007-12-03 2009-06-11 The Regents Of The University Of California Oxsterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and wnt signaling
US20100112030A1 (en) * 2007-03-16 2010-05-06 The Regents Of The University Of California Role of hedgehog signaling in atherosclerosis and cardiovascular disease
EP2459581A4 (en) * 2009-07-29 2012-12-26 Univ Chicago LIVER X-RECEPTOR AGONISTS
KR20150013232A (ko) 2012-05-07 2015-02-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 골형성 및 헤지호그 신호전달을 유도하고 지방생성을 억제하는 옥시스테롤 유사체 oxy133
CN105263500A (zh) 2013-05-02 2016-01-20 加利福尼亚大学董事会 骨选择性成骨性氧固醇-骨靶向剂
CN114315947B (zh) * 2021-11-17 2023-10-03 王涛 一种由22-甾醇作为原料合成胆固醇和25-羟基胆固醇的新方法
CN116789726A (zh) * 2022-01-28 2023-09-22 珂阑(上海)医药科技有限公司 甾类化合物、其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080937A (en) * 1960-11-07 1963-03-12 Garbell Res Foundation Combined acoustic wall and exhaust gas deflector in operation of jet engines
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol

Also Published As

Publication number Publication date
AT342793B (de) 1978-04-25
DE2453648A1 (de) 1975-05-15
FR2250764B1 (https=) 1979-08-03
JPS5077360A (https=) 1975-06-24
ATA899274A (de) 1977-08-15
FR2250764A1 (https=) 1975-06-06
CH599247A5 (https=) 1978-05-31
US3887545A (en) 1975-06-03
NL7414675A (nl) 1975-05-14
BE821983A (fr) 1975-05-09
DE2453648B2 (de) 1980-06-26
JPS5438098B2 (https=) 1979-11-19
DE2453648C3 (de) 1981-08-06

Similar Documents

Publication Publication Date Title
GB1443680A (en) Manufacture of hydroxylated chloesterol derivatives
Zaffaroni Absorption spectra of sulfuric acid chromogens obtained from adrenal steroids and related compounds
Malhotra et al. Chemistry of Conjugate Anions and Enols. V. Stereochemistry, Kinetics, and Mechanism of the Acid-and Enzymatic-Catalyzed Isomerization of 5-3-Keto Steroids1, 2
GB1531047A (en) Steroid sulphoxides and their preparation
Brodie et al. The stereochemical course of the catalytic hydrogenation of ring A unsaturated steroids
GB1242194A (en) A new oestratriol and a process for its manufacture
EP0050325A3 (en) Process for the preparation of intermediates in the synthesis of vitamin-d3 metabolites, and intermediates
KR830002800A (ko) 서당 유도체
CH614217A5 (en) Process for the preparation of 1,3,5(10)-8alpha-oestratrienes
George et al. Oxygen Oxidation of Triphenylsilyllithium
Marshall et al. Opening the B10H102-cage to produce B10H12 (Et2S) 2
NAGAI et al. Studies on the constituents of Saxifragaceous plants. I. Two triterpene acids of Peltoboykinia tellimoides (MAXIM.) HARA
JPS5476529A (en) Addition reaction method
Tsujimura et al. Pathway from progesterone to 5α-reduced C19 steroids not involving androstenedione and testosterone in immature mouse testes in vitro
US3109850A (en) Delta5-androsteno-3, 11, 17-triol and the esters thereof
GB1308849A (en) Process for the preparation of 6alpha-methyl-19-nor-pregnenes
GB1277266A (en) 07-acetylgonanes and derivatives therefor
GB1309670A (en) Pyranosides
Schneider Enzymatic reduction of compound E-21-aldehyde to compound E
GB1244560A (en) Halogenated steroids and process for the manufacture thereof
GB1504132A (en) 6beta-fluorosteroids of the pregnane series
GB1450807A (en) Cardenolide glycosides and process for their manufacture
GB1468473A (en) Method for the preparation of steryl beta-d-glucoside palmitates
GB1529249A (en) 21-acetals and mixed acetals of steroidal 21-aldehydes intermediates and methods of preparation
GB1130052A (en) Improvements in or relating to steroids and intermediates for the production thereof

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee