GB1438574A - 1,n6-ethenoadenosine cyclophosphate and cyclophosphonate compounds - Google Patents

1,n6-ethenoadenosine cyclophosphate and cyclophosphonate compounds

Info

Publication number
GB1438574A
GB1438574A GB4322673A GB4322673A GB1438574A GB 1438574 A GB1438574 A GB 1438574A GB 4322673 A GB4322673 A GB 4322673A GB 4322673 A GB4322673 A GB 4322673A GB 1438574 A GB1438574 A GB 1438574A
Authority
GB
United Kingdom
Prior art keywords
compounds
alkyl
formula
amino
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4322673A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of GB1438574A publication Critical patent/GB1438574A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/14—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB4322673A 1972-10-10 1973-09-14 1,n6-ethenoadenosine cyclophosphate and cyclophosphonate compounds Expired GB1438574A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29588972A 1972-10-10 1972-10-10
US378220A US3872098A (en) 1972-10-10 1973-07-11 1,n{hu 6{b ethenoadenosine cyclophosphate compounds

Publications (1)

Publication Number Publication Date
GB1438574A true GB1438574A (en) 1976-06-09

Family

ID=26969389

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4322673A Expired GB1438574A (en) 1972-10-10 1973-09-14 1,n6-ethenoadenosine cyclophosphate and cyclophosphonate compounds

Country Status (5)

Country Link
US (1) US3872098A (https=)
JP (1) JPS4986398A (https=)
DE (2) DE2365720A1 (https=)
FR (1) FR2201897A1 (https=)
GB (1) GB1438574A (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960840A (en) * 1972-12-29 1976-06-01 University Of Illinois Foundaton Fluorescent derivatives of adenine-containing compounds
US4058659A (en) * 1974-05-31 1977-11-15 Icn Pharmaceuticals, Inc. 6,8-Disubstituted purine derivatives of 9-β-D-ribofuranosyl 3',5'-cyclic phosphate
US4048307A (en) * 1974-12-26 1977-09-13 Asahi Kasei Kogyo Kabushiki Kaisha Cyclic adenosine monophosphate 8-substituted derivatives
JPS5312892A (en) * 1976-07-23 1978-02-04 Kikkoman Corp Novel 1,n6-etheno-2-substituted-adenosine-3,5-cyclic phosphoric acid and its preparation
JPS5841895A (ja) * 1981-09-04 1983-03-11 Yamasa Shoyu Co Ltd ７−オキソピリド〔２，１−ｉ〕プリンリボヌクレオシド誘導体およびその合成法
JPS60239496A (ja) * 1984-05-11 1985-11-28 Kikkoman Corp Ｎ↑６−置換−アデノシン−３′，５′−環状リン酸及びその塩の製法
US5086176A (en) * 1989-03-29 1992-02-04 Merrell Dow Pharmaceuticals Inc. Tricyclic fused adenine derivatives
US20040186282A1 (en) * 2003-03-20 2004-09-23 Chait Edward M. Synthesis and method of purification of cyclic nucleotide derivatives
AU2010226466A1 (en) * 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1257546A (https=) * 1968-09-10 1971-12-22
US3558595A (en) * 1969-02-28 1971-01-26 Syntex Corp 2'-cyclic esters and 5'-cyclic esters of 3'-deoxy - 3' - dihydroxyphosphinylmethyl - beta - d - ribofuranosylnucleoside derivatives and intermediates therefor

Also Published As

Publication number Publication date
FR2201897A1 (https=) 1974-05-03
US3872098A (en) 1975-03-18
DE2350608A1 (de) 1974-04-25
JPS4986398A (https=) 1974-08-19
DE2365720A1 (de) 1976-01-15

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Legal Events

Date Code Title Description
CSNS Application of which complete specification have been accepted and published, but patent is not sealed