GB1428793A - Cephalosporins - Google Patents

Cephalosporins

Info

Publication number
GB1428793A
GB1428793A GB5130473A GB5130473A GB1428793A GB 1428793 A GB1428793 A GB 1428793A GB 5130473 A GB5130473 A GB 5130473A GB 5130473 A GB5130473 A GB 5130473A GB 1428793 A GB1428793 A GB 1428793A
Authority
GB
United Kingdom
Prior art keywords
substituted
compounds
group
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5130473A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1428793A publication Critical patent/GB1428793A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
GB5130473A 1972-11-13 1973-11-05 Cephalosporins Expired GB1428793A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30606472A 1972-11-13 1972-11-13
US31448572A 1972-12-12 1972-12-12
US05/392,159 US3947413A (en) 1972-11-13 1973-08-27 3-α-Substituted cephalosporins
US77640177A 1977-03-10 1977-03-10
US05/902,586 US4258040A (en) 1972-11-13 1978-05-04 Cephalosporin compounds

Publications (1)

Publication Number Publication Date
GB1428793A true GB1428793A (en) 1976-03-17

Family

ID=27540920

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5130473A Expired GB1428793A (en) 1972-11-13 1973-11-05 Cephalosporins

Country Status (8)

Country Link
US (2) US3947413A (enExample)
JP (3) JPS49133391A (enExample)
CH (1) CH606010A5 (enExample)
DE (1) DE2356388A1 (enExample)
FR (1) FR2206085B1 (enExample)
GB (1) GB1428793A (enExample)
NL (1) NL7314893A (enExample)
SE (1) SE422801B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2141124A (en) * 1983-05-17 1984-12-12 Chinoin Gyogyszer Es Vegyeszet Phosphorus containing semisynthetic cephalosporanic and penicillanic derivatives

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1032533A (en) * 1973-09-07 1978-06-06 William H. Koster Process for the production of cephalosporin compounds
JPS5165789A (en) * 1974-11-30 1976-06-07 Sankyo Co 77 metokishisefuarosuhorinkagobutsuno seiho
JPS5168589A (enExample) * 1974-12-06 1976-06-14 Shionogi Seiyaku Kk
US4012380A (en) * 1974-12-10 1977-03-15 Eli Lilly And Company 7-Acylamino-3-acyl-2(or 3)cephems
SE432254B (sv) * 1975-02-04 1984-03-26 Fujisawa Pharmaceutical Co Analogiforfarande for framstellning av 3-substituerade 7-(alfa,alfa-disubstituerade acetamido)-3-cefem-4-karboxylsyror
DE2620094A1 (de) * 1975-05-12 1976-12-02 Takeda Chemical Industries Ltd Cephalosporinverbindungen und verfahren zu ihrer herstellung
FR2511375A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine, leur preparation et les medicaments qui les contiennent
FR2531711A1 (fr) * 1982-08-13 1984-02-17 Rhone Poulenc Sante Nouveaux derives de la cephalosporine, leur preparation et les medicaments qui les contiennent
FR2531710B2 (fr) * 1982-08-13 1986-05-23 Rhone Poulenc Sante Nouveaux derives de la cephalosporine, leur preparation et les medicaments qui les contiennent
HU188874B (en) * 1983-04-19 1986-05-28 Biogal Gyogyszergyar,Hu Process for producing new 7-acylamido-3-acylaminomethyl-ceph-3-eme-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof
JPS624290A (ja) * 1985-06-28 1987-01-10 Toyama Chem Co Ltd 新規なセフアロスポリン類およびその塩
JPH072751B2 (ja) * 1985-10-04 1995-01-18 富山化学工業株式会社 新規なセフアロスポリン類およびその塩
JPS6287592A (ja) * 1985-10-11 1987-04-22 Toyama Chem Co Ltd 新規なセフアロスポリン類およびその塩
EP0473767A1 (en) * 1990-03-23 1992-03-11 Eastman Kodak Company Virtual memory management and allocation arrangement for digital data processing system
DE4037841A1 (de) * 1990-11-28 1992-06-04 Bayer Ag Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA2702257C (en) 2007-10-09 2016-07-12 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
US9975905B2 (en) * 2013-03-12 2018-05-22 Gladius Pharmaceuticals Corporation Derivatized 3-styryl-cephalosporins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799922A (en) * 1971-11-17 1974-03-26 Smithkline Corp 4-substituted 3-cephem compounds
BE793448A (fr) * 1971-12-31 1973-06-28 Roussel Uclaf Procede de preparation de nouveaux derives des cephalosporines et produits obtenus
FR2166623A5 (en) * 1971-12-31 1973-08-17 Roussel Uclaf 7-substd-phenylacetamido-cephalosporin derivs - - antibiotics active against streptococci and staphylococci
NL7304755A (enExample) * 1972-04-14 1973-10-16
US4013651A (en) * 1975-05-12 1977-03-22 Eli Lilly And Company 3-substituted amino-cephalosporins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2141124A (en) * 1983-05-17 1984-12-12 Chinoin Gyogyszer Es Vegyeszet Phosphorus containing semisynthetic cephalosporanic and penicillanic derivatives

Also Published As

Publication number Publication date
CH606010A5 (enExample) 1978-10-13
NL7314893A (enExample) 1974-05-15
JPS57112397A (en) 1982-07-13
FR2206085A1 (enExample) 1974-06-07
US4258040A (en) 1981-03-24
DE2356388A1 (de) 1974-05-22
JPS49133391A (enExample) 1974-12-21
AU6215273A (en) 1975-05-08
JPS57112395A (en) 1982-07-13
FR2206085B1 (enExample) 1976-12-03
US3947413A (en) 1976-03-30
SE422801B (sv) 1982-03-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee