ES461983A1 - Un procedimiento para la preparacion de nuevas cefalospori- nas. - Google Patents

Un procedimiento para la preparacion de nuevas cefalospori- nas.

Info

Publication number
ES461983A1
ES461983A1 ES461983A ES461983A ES461983A1 ES 461983 A1 ES461983 A1 ES 461983A1 ES 461983 A ES461983 A ES 461983A ES 461983 A ES461983 A ES 461983A ES 461983 A1 ES461983 A1 ES 461983A1
Authority
ES
Spain
Prior art keywords
reaction
cephalosporin
appropriate
cephalosporins
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES461983A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES461983A1 publication Critical patent/ES461983A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los compuestos de esta invención son isómeros sin o bien son mezclas de isómeros sin y anti que contienen como mínimo un 75 % del isómero sin. Preferiblemente estas mezclas de isómeros contienen por lo menos un 90 % del isómero sin y no más del 10 % del isómero anti. Todavía mejor, los compuestos son isómeros sin esencialmente exentos del correspondiente isómero anti. Las realizaciones preferidas de esta invención son los isómeros sin de los compuestos de fórmula I donde R1 es metilo o etilo, n es 1 ó 2 y R2 es hidrógeno, pivaloiloximetilo, acetoximetilo, metoximetilo, acetonilo, fenacilo, p-nitrobencilo, beta, beta, beta-tricloroetilo, 3-ftalidilo o 5-indanilo.
ES461983A 1976-08-30 1977-08-30 Un procedimiento para la preparacion de nuevas cefalospori- nas. Expired ES461983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71902576A 1976-08-30 1976-08-30

Publications (1)

Publication Number Publication Date
ES461983A1 true ES461983A1 (es) 1978-12-01

Family

ID=24888488

Family Applications (1)

Application Number Title Priority Date Filing Date
ES461983A Expired ES461983A1 (es) 1976-08-30 1977-08-30 Un procedimiento para la preparacion de nuevas cefalospori- nas.

Country Status (18)

Country Link
JP (1) JPS5331693A (es)
AU (1) AU510280B2 (es)
BE (1) BE858112A (es)
CA (1) CA1115267A (es)
CH (1) CH638812A5 (es)
DE (1) DE2739080A1 (es)
DK (1) DK382977A (es)
ES (1) ES461983A1 (es)
FI (1) FI64803C (es)
FR (1) FR2372167A1 (es)
GB (1) GB1557423A (es)
GR (1) GR74023B (es)
IE (1) IE46431B1 (es)
LU (1) LU78027A1 (es)
NL (1) NL7709466A (es)
SE (1) SE7709646L (es)
YU (1) YU204877A (es)
ZA (1) ZA775193B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
FI782683A (fi) * 1978-07-19 1980-01-20 Hoffmann La Roche Kefalosporinestrar och -estrar
US4973107A (en) * 1989-11-01 1990-11-27 Graham John M Dual pressure air brake system
EP1379531A2 (en) * 2001-04-19 2004-01-14 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4286089A (en) * 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
NZ182649A (en) * 1975-11-27 1979-11-01 Beecham Group Ltd Cephalosporins,intermediates, and phrmaceutical compositions
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins

Also Published As

Publication number Publication date
FI64803C (fi) 1984-01-10
NL7709466A (nl) 1978-03-02
DK382977A (da) 1978-03-01
IE771799L (en) 1978-02-28
BE858112A (fr) 1978-02-27
IE46431B1 (en) 1983-06-15
FR2372167B1 (es) 1981-11-27
AU510280B2 (en) 1980-06-19
DE2739080A1 (de) 1978-03-02
GB1557423A (en) 1979-12-12
JPS5331693A (en) 1978-03-25
FI772549A (fi) 1978-03-01
CH638812A5 (en) 1983-10-14
CA1115267A (en) 1981-12-29
AU2797277A (en) 1979-02-22
FR2372167A1 (fr) 1978-06-23
GR74023B (es) 1984-06-06
YU204877A (en) 1982-10-31
ZA775193B (en) 1978-07-26
SE7709646L (sv) 1978-03-01
FI64803B (fi) 1983-09-30
LU78027A1 (es) 1978-04-27

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