GB1389540A - Derivatives of alpha-aminocephalosporins - Google Patents

Derivatives of alpha-aminocephalosporins

Info

Publication number
GB1389540A
GB1389540A GB5625771A GB5625771A GB1389540A GB 1389540 A GB1389540 A GB 1389540A GB 5625771 A GB5625771 A GB 5625771A GB 5625771 A GB5625771 A GB 5625771A GB 1389540 A GB1389540 A GB 1389540A
Authority
GB
United Kingdom
Prior art keywords
iii
derivatives
formula
compound
alkanoyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5625771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE792228D priority Critical patent/BE792228A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to GB5625771A priority patent/GB1389540A/en
Priority to ZA728474A priority patent/ZA728474B/en
Priority to CH1745272A priority patent/CH586708A5/de
Priority to DK599372AA priority patent/DK138950B/en
Priority to CH1582876A priority patent/CH602749A5/xx
Priority to DE19722258994 priority patent/DE2258994A1/en
Priority to NL7216350A priority patent/NL7216350A/xx
Priority to FR7242905A priority patent/FR2162199B1/fr
Priority to JP47119982A priority patent/JPS4864093A/ja
Priority to AU49511/72A priority patent/AU475142B2/en
Publication of GB1389540A publication Critical patent/GB1389540A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Fodder In General (AREA)

Abstract

1389540 Derivatives of α-aminocephalosporins BRISTOL-MYERS CO 20 Nov 1972 [3 Dec 1971] 56257/71 Heading C2C Novel α-aminocephalosporin derivatives having the Formula III or (IV) and acid addition salts thereof, wherein R is cyclohexadienyl, 2- or 3-thienyl, phenyl, or phenyl substituted by one or more groups selected from halo, hydroxy, C 1-6 alkyl, C 1-6 alkanoyl, C 1-6 alkanoyloxy, C 1-6 alkoxy, C 1-6 alkanoylamino, C 1-6 alkylmercapto, nitro, trifluoromethyl, and amino; and A is a cephem moiety of formula in which R<SP>1</SP> is hydrogen or a salt-forming ion and X is hydrogen or C 1-6 alkanoyloxy; are prepared by reacting acetaldehyde with an α-aminocephalosporin compound of Formula (I) or an acid addition salt thereof wherein A and R are as defined above. The compound (III) is produced by carrying out the reaction in a substantially anhydrous medium in which the products is insoluble, such as acetone or isopropanol. In a medium which is a solvent for the product, e.g. methylene chloride, and preferably contains water, the cyclic compound (IV) is produced. The products (III) and IV and their salts have antibiotic activity, and may be admixed with a pharmaceutically acceptable carrier to provide antibiotic pharmaceutical compositions.
GB5625771A 1971-12-03 1971-12-03 Derivatives of alpha-aminocephalosporins Expired GB1389540A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BE792228D BE792228A (en) 1971-12-03 ANTIBACTERIAL AGENTS AND METHOD FOR PREPARING THEM
GB5625771A GB1389540A (en) 1971-12-03 1971-12-03 Derivatives of alpha-aminocephalosporins
ZA728474A ZA728474B (en) 1971-12-03 1972-11-29 Antibacterial agents and a process for their preparation
CH1582876A CH602749A5 (en) 1971-12-03 1972-11-30
DK599372AA DK138950B (en) 1971-12-03 1972-11-30 Analogous process for the preparation of alpha-aminopenicillin or cephalosporin derivatives.
CH1745272A CH586708A5 (en) 1971-12-03 1972-11-30
DE19722258994 DE2258994A1 (en) 1971-12-03 1972-12-01 ANTIBACTERIAL AGENTS AND METHODS FOR THEIR PRODUCTION
NL7216350A NL7216350A (en) 1971-12-03 1972-12-01
FR7242905A FR2162199B1 (en) 1971-12-03 1972-12-01
JP47119982A JPS4864093A (en) 1971-12-03 1972-12-01
AU49511/72A AU475142B2 (en) 1971-12-03 1972-12-01 Antibacterial agents and a process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5625771A GB1389540A (en) 1971-12-03 1971-12-03 Derivatives of alpha-aminocephalosporins

Publications (1)

Publication Number Publication Date
GB1389540A true GB1389540A (en) 1975-04-03

Family

ID=10476184

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5625771A Expired GB1389540A (en) 1971-12-03 1971-12-03 Derivatives of alpha-aminocephalosporins

Country Status (10)

Country Link
JP (1) JPS4864093A (en)
AU (1) AU475142B2 (en)
BE (1) BE792228A (en)
CH (2) CH586708A5 (en)
DE (1) DE2258994A1 (en)
DK (1) DK138950B (en)
FR (1) FR2162199B1 (en)
GB (1) GB1389540A (en)
NL (1) NL7216350A (en)
ZA (1) ZA728474B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50129587A (en) * 1974-03-28 1975-10-13
US4091213A (en) * 1975-12-12 1978-05-23 Bristol-Myers Company 7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives
ES2073458T3 (en) * 1989-02-06 1995-08-16 Purzer Pharmaceutical Co Ltd PROCEDURE FOR THE PREPARATION OF SALT DERIVATIVES OF ALKALINE METALS FROM ACID 7-AMINO-CEPHALOSPORANIC 3.7 REPLACED.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1458925A (en) * 1963-01-25 1966-04-29 Bristol Myers Co Process for the preparation of new alpha-aminopenicillins
ES377996A1 (en) * 1970-03-26 1972-10-16 Gallardo Antonio Sa A procedure for the obtaining of new derivatives of the 6-amino-penicilanico acid and its salts. (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
DE2258994A1 (en) 1973-06-20
JPS4864093A (en) 1973-09-05
DK138950B (en) 1978-11-20
BE792228A (en) 1973-06-01
CH602749A5 (en) 1978-07-31
CH586708A5 (en) 1977-04-15
ZA728474B (en) 1973-08-29
FR2162199B1 (en) 1976-07-02
AU4951172A (en) 1974-06-06
FR2162199A1 (en) 1973-07-13
AU475142B2 (en) 1976-08-12
NL7216350A (en) 1973-06-05
DK138950C (en) 1979-05-07

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee