GB1427881A - Mixtures containing nitroglycerin and polyvinyl-pyrrolidone - Google Patents
Mixtures containing nitroglycerin and polyvinyl-pyrrolidoneInfo
- Publication number
- GB1427881A GB1427881A GB62074A GB62074A GB1427881A GB 1427881 A GB1427881 A GB 1427881A GB 62074 A GB62074 A GB 62074A GB 62074 A GB62074 A GB 62074A GB 1427881 A GB1427881 A GB 1427881A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nitroglycerin
- pvp
- optionally
- mixtures
- jan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 title abstract 8
- 239000000006 Nitroglycerin Substances 0.000 title abstract 8
- 229960003711 glyceryl trinitrate Drugs 0.000 title abstract 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 title abstract 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 6
- 239000002775 capsule Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- 229930008281 A03AD01 - Papaverine Natural products 0.000 abstract 1
- 229930003347 Atropine Natural products 0.000 abstract 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229960003556 aminophylline Drugs 0.000 abstract 1
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 229940125683 antiemetic agent Drugs 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 abstract 1
- 229960000396 atropine Drugs 0.000 abstract 1
- 229920003086 cellulose ether Polymers 0.000 abstract 1
- 239000003218 coronary vasodilator agent Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- -1 dragÚes Substances 0.000 abstract 1
- SNFOERUNNSHUGP-ZXZARUISSA-N erythrityl tetranitrate Chemical compound [O-][N+](=O)OC[C@@H](O[N+]([O-])=O)[C@@H](O[N+]([O-])=O)CO[N+]([O-])=O SNFOERUNNSHUGP-ZXZARUISSA-N 0.000 abstract 1
- YVPJCJLMRRTDMQ-UHFFFAOYSA-N ethyl diazoacetate Chemical compound CCOC(=O)C=[N+]=[N-] YVPJCJLMRRTDMQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008240 homogeneous mixture Substances 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- DGMJZELBSFOPHH-KVTDHHQDSA-N mannite hexanitrate Chemical compound [O-][N+](=O)OC[C@@H](O[N+]([O-])=O)[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)CO[N+]([O-])=O DGMJZELBSFOPHH-KVTDHHQDSA-N 0.000 abstract 1
- 229960001765 mannitol hexanitrate Drugs 0.000 abstract 1
- 239000004081 narcotic agent Substances 0.000 abstract 1
- 229960001789 papaverine Drugs 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229960000278 theophylline Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732301664 DE2301664C3 (de) | 1973-01-13 | 1973-01-13 | Oral verabreichbares, Nitroglycerin enthaltendes Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1427881A true GB1427881A (en) | 1976-03-10 |
Family
ID=5868955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB62074A Expired GB1427881A (en) | 1973-01-13 | 1974-01-07 | Mixtures containing nitroglycerin and polyvinyl-pyrrolidone |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE809512A (enrdf_load_stackoverflow) |
| DE (1) | DE2301664C3 (enrdf_load_stackoverflow) |
| DK (1) | DK137364C (enrdf_load_stackoverflow) |
| FR (1) | FR2213779B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1427881A (enrdf_load_stackoverflow) |
| IE (1) | IE38721B1 (enrdf_load_stackoverflow) |
| LU (1) | LU69138A1 (enrdf_load_stackoverflow) |
| NL (1) | NL158701B (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323577A (en) | 1979-11-13 | 1982-04-06 | Nippon Kayaku Kabushiki Kaisha | Aqueous solution of nitroglycerin |
| US4450877A (en) * | 1977-11-03 | 1984-05-29 | Hoechst Aktiengesellschaft | Pharmaceutical preparations in solid unit dosage form |
| US4470962A (en) * | 1979-08-14 | 1984-09-11 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix |
| US4482534A (en) * | 1980-12-16 | 1984-11-13 | Forest Laboratories, Inc. | Nitroglycerin preparations |
| US4482533A (en) * | 1982-01-11 | 1984-11-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
| EP0304730A1 (de) * | 1987-08-27 | 1989-03-01 | G. Pohl-Boskamp GmbH & Co. Chemisch-pharmazeutische Fabrik | N-Alkylscopolaminiumsalz und Nitroglycerin enthaltendes Arzneimittel, Verfahren zu dessen Herstellung und dessen Verwendung |
| AU591185B2 (en) * | 1985-10-15 | 1989-11-30 | Eurand International S.P.A. | Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained |
| US5128138A (en) * | 1989-07-21 | 1992-07-07 | Izhak Blank | Estradiol compositions and methods for topical application |
| US5232703A (en) * | 1989-07-21 | 1993-08-03 | Izhak Blank | Estradiol compositions and methods for topical application |
| ITMI20121654A1 (it) * | 2012-10-03 | 2014-04-04 | Dipharma Francis Srl | Composizioni farmaceutiche |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1561204A (en) * | 1977-06-01 | 1980-02-13 | Ici Ltd | Sustained release pharmaceutical composition |
| SU806037A1 (ru) * | 1978-04-06 | 1981-02-23 | Всесоюзный Кардиологический Научныйцентр Amh Cccp | Антиангинальное средство |
| DE3109783C2 (de) * | 1981-03-13 | 1987-04-02 | Schwarz GmbH, 4019 Monheim | Verfahren zur Herstellung einer ethanolfreien Nitroglycerinlösung mit einer Konzentration von etwa 1 mg Nitroglycerin/ml |
| DE3237284A1 (de) * | 1982-10-08 | 1984-04-12 | G. Pohl-Boskamp GmbH & Co Chemisch-pharmazeutische Fabrik, 2214 Hohenlockstedt | Loesungsvermittlerfreie, waessrige nitroglycerinloesung |
| US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| SE457326B (sv) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
| RU2195932C2 (ru) * | 2000-09-18 | 2003-01-10 | Гаврилов Андрей Станиславович | Способ получения антиангинального лекарственного средства |
-
1973
- 1973-01-13 DE DE19732301664 patent/DE2301664C3/de not_active Expired
- 1973-12-27 FR FR7346453A patent/FR2213779B1/fr not_active Expired
-
1974
- 1974-01-07 GB GB62074A patent/GB1427881A/en not_active Expired
- 1974-01-08 BE BE139619A patent/BE809512A/xx not_active IP Right Cessation
- 1974-01-08 IE IE3674A patent/IE38721B1/xx unknown
- 1974-01-08 DK DK8274A patent/DK137364C/da not_active IP Right Cessation
- 1974-01-10 LU LU69138A patent/LU69138A1/xx unknown
- 1974-01-11 NL NL7400386A patent/NL158701B/xx not_active IP Right Cessation
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450877A (en) * | 1977-11-03 | 1984-05-29 | Hoechst Aktiengesellschaft | Pharmaceutical preparations in solid unit dosage form |
| US4470962A (en) * | 1979-08-14 | 1984-09-11 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix |
| US4323577A (en) | 1979-11-13 | 1982-04-06 | Nippon Kayaku Kabushiki Kaisha | Aqueous solution of nitroglycerin |
| US4482534A (en) * | 1980-12-16 | 1984-11-13 | Forest Laboratories, Inc. | Nitroglycerin preparations |
| US4533540A (en) * | 1980-12-16 | 1985-08-06 | Forest Laboratories, Inc. | Nitroglycerin-containing polymeric matrix for sustained release on topical application |
| US4482533A (en) * | 1982-01-11 | 1984-11-13 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing propranolol |
| AU591185B2 (en) * | 1985-10-15 | 1989-11-30 | Eurand International S.P.A. | Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained |
| EP0304730A1 (de) * | 1987-08-27 | 1989-03-01 | G. Pohl-Boskamp GmbH & Co. Chemisch-pharmazeutische Fabrik | N-Alkylscopolaminiumsalz und Nitroglycerin enthaltendes Arzneimittel, Verfahren zu dessen Herstellung und dessen Verwendung |
| US5128138A (en) * | 1989-07-21 | 1992-07-07 | Izhak Blank | Estradiol compositions and methods for topical application |
| US5232703A (en) * | 1989-07-21 | 1993-08-03 | Izhak Blank | Estradiol compositions and methods for topical application |
| ITMI20121654A1 (it) * | 2012-10-03 | 2014-04-04 | Dipharma Francis Srl | Composizioni farmaceutiche |
| WO2014053328A3 (en) * | 2012-10-03 | 2014-05-30 | Dipharma Francis S.R.L. | Pharmaceutical compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| LU69138A1 (enrdf_load_stackoverflow) | 1975-04-11 |
| IE38721L (en) | 1974-07-13 |
| DE2301664A1 (de) | 1974-08-01 |
| NL7400386A (enrdf_load_stackoverflow) | 1974-07-16 |
| NL158701B (nl) | 1978-12-15 |
| FR2213779A1 (enrdf_load_stackoverflow) | 1974-08-09 |
| BE809512A (fr) | 1974-07-08 |
| DK137364B (da) | 1978-02-27 |
| FR2213779B1 (enrdf_load_stackoverflow) | 1978-01-06 |
| DE2301664C3 (de) | 1979-07-12 |
| DK137364C (da) | 1978-07-31 |
| IE38721B1 (en) | 1978-05-24 |
| DE2301664B2 (de) | 1978-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |