GB1411495A - Substituted-4-biphenyl-3-hydroxybutyric acids esters and amides and pharmaceutical compositions containing them - Google Patents
Substituted-4-biphenyl-3-hydroxybutyric acids esters and amides and pharmaceutical compositions containing themInfo
- Publication number
- GB1411495A GB1411495A GB3884373A GB3884373A GB1411495A GB 1411495 A GB1411495 A GB 1411495A GB 3884373 A GB3884373 A GB 3884373A GB 3884373 A GB3884373 A GB 3884373A GB 1411495 A GB1411495 A GB 1411495A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- formula
- alkoxy
- salts
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 4
- -1 acids esters Chemical class 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 11
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- RYNCQNDSXKIJIB-UHFFFAOYSA-N 3-(3-fluoro-4-phenylphenyl)-3-hydroxybutanoic acid Chemical class FC1=CC(C(O)(CC(O)=O)C)=CC=C1C1=CC=CC=C1 RYNCQNDSXKIJIB-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000007127 saponification reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
- C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
- C07C17/208—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/64—Acyl halides
- C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2240441A DE2240441A1 (de) | 1972-08-17 | 1972-08-17 | Neue biphenylderivate und verfahren zur herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1411495A true GB1411495A (en) | 1975-10-29 |
Family
ID=5853790
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3884373A Expired GB1411495A (en) | 1972-08-17 | 1973-08-16 | Substituted-4-biphenyl-3-hydroxybutyric acids esters and amides and pharmaceutical compositions containing them |
| GB3884473A Expired GB1410852A (en) | 1972-08-17 | 1973-08-16 | Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3884473A Expired GB1410852A (en) | 1972-08-17 | 1973-08-16 | Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them |
Country Status (19)
| Country | Link |
|---|---|
| JP (2) | JPS49124051A (fr) |
| AT (3) | AT323144B (fr) |
| AU (2) | AU5930873A (fr) |
| BE (3) | BE803733A (fr) |
| BG (3) | BG21844A3 (fr) |
| CH (1) | CH588435A5 (fr) |
| CS (3) | CS165387B2 (fr) |
| DD (2) | DD108071A5 (fr) |
| DE (1) | DE2240441A1 (fr) |
| ES (4) | ES417884A1 (fr) |
| FR (2) | FR2196168B1 (fr) |
| GB (2) | GB1411495A (fr) |
| HU (2) | HU166517B (fr) |
| IL (2) | IL43004A0 (fr) |
| NL (2) | NL7311301A (fr) |
| PL (2) | PL94510B1 (fr) |
| RO (2) | RO62917A (fr) |
| SU (11) | SU484679A3 (fr) |
| ZA (3) | ZA735628B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2457275A1 (fr) * | 1979-05-21 | 1980-12-19 | Fabre Sa Pierre | Acides p-biphenyl-4 methyl-2 buten-3 oiques utiles dans le traitement des rhumatismes |
| RU2686489C1 (ru) * | 2018-12-27 | 2019-04-29 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет (СПбГУ)" | Способ получения α-диазокарбонильных соединений в водной среде |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2162038A1 (de) * | 1970-05-05 | 1972-08-17 | William H Rorer Ine , Fort Washington, Pa (V St A ) | Verfahren zur Herstellung von synthe tischen Alkansauren und deren Derivaten |
| BE776316R (fr) * | 1971-03-10 | 1972-06-06 | Rorer Inc William H | Nouveaux derives d'acides phenyl-acetiques substitues et procede pour leur |
-
1972
- 1972-08-17 DE DE2240441A patent/DE2240441A1/de active Pending
-
1973
- 1973-08-14 CH CH1170773A patent/CH588435A5/xx not_active IP Right Cessation
- 1973-08-14 AT AT710873A patent/AT323144B/de not_active IP Right Cessation
- 1973-08-14 AT AT711273A patent/AT328427B/de not_active IP Right Cessation
- 1973-08-14 ES ES417884A patent/ES417884A1/es not_active Expired
- 1973-08-14 ES ES417883A patent/ES417883A1/es not_active Expired
- 1973-08-14 AT AT710773A patent/AT323143B/de not_active IP Right Cessation
- 1973-08-15 BG BG027671A patent/BG21844A3/xx unknown
- 1973-08-15 HU HUTO926A patent/HU166517B/hu unknown
- 1973-08-15 HU HUTO925A patent/HU166516B/hu unknown
- 1973-08-15 SU SU1958288A patent/SU484679A3/ru active
- 1973-08-15 SU SU1958290A patent/SU511846A3/ru active
- 1973-08-15 BG BG024327A patent/BG21197A3/xx unknown
- 1973-08-15 DD DD172906A patent/DD108071A5/xx unknown
- 1973-08-15 DD DD172907A patent/DD107901A5/xx unknown
- 1973-08-15 SU SU1958291A patent/SU482039A3/ru active
- 1973-08-15 BG BG24328A patent/BG22069A3/xx not_active Expired
- 1973-08-16 JP JP48092052A patent/JPS49124051A/ja active Pending
- 1973-08-16 GB GB3884373A patent/GB1411495A/en not_active Expired
- 1973-08-16 CS CS4904A patent/CS165387B2/cs unknown
- 1973-08-16 AU AU59308/73A patent/AU5930873A/en not_active Expired
- 1973-08-16 IL IL43004A patent/IL43004A0/xx unknown
- 1973-08-16 AU AU59309/73A patent/AU476340B2/en not_active Expired
- 1973-08-16 JP JP48092053A patent/JPS49124052A/ja active Pending
- 1973-08-16 PL PL1973186474A patent/PL94510B1/pl unknown
- 1973-08-16 CS CS5793A patent/CS165385B2/cs unknown
- 1973-08-16 IL IL43003A patent/IL43003A0/xx unknown
- 1973-08-16 ZA ZA00735628A patent/ZA735628B/xx unknown
- 1973-08-16 GB GB3884473A patent/GB1410852A/en not_active Expired
- 1973-08-16 PL PL1973164708A patent/PL90397B1/pl unknown
- 1973-08-16 NL NL7311301A patent/NL7311301A/xx unknown
- 1973-08-16 ZA ZA00735629A patent/ZA735629B/xx unknown
- 1973-08-16 NL NL7311300A patent/NL7311300A/xx unknown
- 1973-08-16 CS CS4903A patent/CS165386B2/cs unknown
- 1973-08-16 ZA ZA00735616A patent/ZA735616B/xx unknown
- 1973-08-17 BE BE134690A patent/BE803733A/fr unknown
- 1973-08-17 BE BE134689A patent/BE803732A/fr unknown
- 1973-08-17 FR FR7330076A patent/FR2196168B1/fr not_active Expired
- 1973-08-17 RO RO7300075821A patent/RO62917A/fr unknown
- 1973-08-17 RO RO7300075822A patent/RO62918A/fr unknown
- 1973-08-17 BE BE134691A patent/BE803734A/fr unknown
- 1973-08-17 FR FR7330075A patent/FR2196167B1/fr not_active Expired
-
1974
- 1974-10-21 SU SU2069576A patent/SU561505A3/ru active
- 1974-10-21 SU SU2069577A patent/SU520907A3/ru active
- 1974-10-21 SU SU2069578A patent/SU511847A3/ru active
- 1974-10-21 SU SU7402069575A patent/SU577967A3/ru active
- 1974-10-21 SU SU2069110A patent/SU554810A3/ru active
- 1974-10-21 SU SU2069774A patent/SU552021A3/ru active
- 1974-10-21 SU SU2069771A patent/SU520030A3/ru active
- 1974-10-21 SU SU2069114A patent/SU538658A3/ru active
- 1974-11-30 ES ES432464A patent/ES432464A1/es not_active Expired
- 1974-11-30 ES ES432465A patent/ES432465A1/es not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |