SU511846A3 - Способ получени -бифенилмасл ных кислот или их солей - Google Patents

Способ получени -бифенилмасл ных кислот или их солей

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Publication number
SU511846A3
SU511846A3 SU1958290A SU1958290A SU511846A3 SU 511846 A3 SU511846 A3 SU 511846A3 SU 1958290 A SU1958290 A SU 1958290A SU 1958290 A SU1958290 A SU 1958290A SU 511846 A3 SU511846 A3 SU 511846A3
Authority
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USSR - Soviet Union
Prior art keywords
acids
salts
obtaining
biphenylbuttonic
general formula
Prior art date
Application number
SU1958290A
Other languages
English (en)
Inventor
Энгель Вольфхард
Тойфель Хельмут
Зеегер Эрнст
Никкль Йозеф
Энгельгардт Гюнтер
Original Assignee
Д-Р Карл Томэ Гмбх (Фирма)
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Application filed by Д-Р Карл Томэ Гмбх (Фирма) filed Critical Д-Р Карл Томэ Гмбх (Фирма)
Application granted granted Critical
Publication of SU511846A3 publication Critical patent/SU511846A3/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/20Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
    • C07C17/202Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
    • C07C17/208Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64Acyl halides
    • C07C57/76Acyl halides containing halogen outside the carbonyl halide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5407Acyclic saturated phosphonium compounds
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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ -БИФЕНИЛМАСЛЯНЫХ ЮГСЛОТ
1
Предлагаетс  способ полученн  новых соедине . НИИ бифеннлмасл ных кислот или их ел лей, d падающих физиологической активностью.
Известен общий метод получ ш  карбоншых кислот взаимопействием сшфтов, алкенов, алкипгалогешиюв с 1,1 дихлорэтиленом в щшсутствии кислоты и трехфтсфистого бора.
Однако, синтез новых соединений, которте обладают более высоким физиологическим действием DO сравнению с известными соепинени ми того же шз ачеюи, на1фимер феюшбутазоном, не тер ет своего шачени  в насто щее врем .
Предлагаютс  - бифенилмасл ные кислоты общей формулы 1
/7 I
CH-CHj-COOH
где R означает атом галог а, или их соли с неорганическими или opnutB etta ми основани ми получать взаимодействием соедиие11ИЙ общей формулы И
СН,
V
где R имеет указанное значение;
X - оксигруши, атом галогена или ацилокснipyisia ,
с 1,1 дихлорэтнленом в присутствии серной кислоты или ее смеси с трехфгористым борюм с последующим выделением целевого продукта и/или расщеплением его на оптические антиподы известными приемами.
Расщепление рацематов на оптцческие антиподы осуществл ют, например, фракционированной крнсталлизацней их солей с. оптически активным основанием, преимущественно хинином. Кислоты общей формулы 1 могут быть переведены в соли с неорганическими или органическими основани ми. В качестве органических оснований преимущественно примен ют диэганоламин, морфЪлин, циклогексифамин и пиперазин.
Исходные соединеаи  общей формулы II, где X означает оксигруппу, могут быть получены известны ми способами, например восстановлением кетонов общей формулы III
SU1958290A 1972-08-17 1973-08-15 Способ получени -бифенилмасл ных кислот или их солей SU511846A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2240441A DE2240441A1 (de) 1972-08-17 1972-08-17 Neue biphenylderivate und verfahren zur herstellung

Publications (1)

Publication Number Publication Date
SU511846A3 true SU511846A3 (ru) 1976-04-25

Family

ID=5853790

Family Applications (11)

Application Number Title Priority Date Filing Date
SU1958288A SU484679A3 (ru) 1972-08-17 1973-08-15 Способ получени производных бифенила
SU1958291A SU482039A3 (ru) 1972-08-17 1973-08-15 Способ получени бифенилилбутеновых кислот или их производных
SU1958290A SU511846A3 (ru) 1972-08-17 1973-08-15 Способ получени -бифенилмасл ных кислот или их солей
SU2069114A SU538658A3 (ru) 1972-08-17 1974-10-21 Способ получени бифенилмасл ных кислот или их солей, или рацематов, или оптически активных антиподов
SU2069577A SU520907A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилилмасл ной кислоты или ее соли
SU2069578A SU511847A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилмасл ной кислоты или ее эфиров или солей
SU2069576A SU561505A3 (ru) 1972-08-17 1974-10-21 Способ получени 3-(4-бифенилил) -масл ной кислоты или ее солей
SU2069110A SU554810A3 (ru) 1972-08-17 1974-10-21 Способ получени производных бифенила или их солей, или рацематов, или оптически активных антиподов
SU2069771A SU520030A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилмасл ной кислоты или ее эфира или ее соли
SU7402069575A SU577967A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилилмасл ной кислоты или ее эфиров или ее амидов или ее солей
SU2069774A SU552021A3 (ru) 1972-08-17 1974-10-21 Способ получени производных бифенила или их солей

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SU1958288A SU484679A3 (ru) 1972-08-17 1973-08-15 Способ получени производных бифенила
SU1958291A SU482039A3 (ru) 1972-08-17 1973-08-15 Способ получени бифенилилбутеновых кислот или их производных

Family Applications After (8)

Application Number Title Priority Date Filing Date
SU2069114A SU538658A3 (ru) 1972-08-17 1974-10-21 Способ получени бифенилмасл ных кислот или их солей, или рацематов, или оптически активных антиподов
SU2069577A SU520907A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилилмасл ной кислоты или ее соли
SU2069578A SU511847A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилмасл ной кислоты или ее эфиров или солей
SU2069576A SU561505A3 (ru) 1972-08-17 1974-10-21 Способ получени 3-(4-бифенилил) -масл ной кислоты или ее солей
SU2069110A SU554810A3 (ru) 1972-08-17 1974-10-21 Способ получени производных бифенила или их солей, или рацематов, или оптически активных антиподов
SU2069771A SU520030A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилмасл ной кислоты или ее эфира или ее соли
SU7402069575A SU577967A3 (ru) 1972-08-17 1974-10-21 Способ получени замещенной бифенилилмасл ной кислоты или ее эфиров или ее амидов или ее солей
SU2069774A SU552021A3 (ru) 1972-08-17 1974-10-21 Способ получени производных бифенила или их солей

Country Status (19)

Country Link
JP (2) JPS49124051A (ru)
AT (3) AT323143B (ru)
AU (2) AU5930873A (ru)
BE (3) BE803732A (ru)
BG (3) BG21844A3 (ru)
CH (1) CH588435A5 (ru)
CS (3) CS165387B2 (ru)
DD (2) DD108071A5 (ru)
DE (1) DE2240441A1 (ru)
ES (4) ES417883A1 (ru)
FR (2) FR2196167B1 (ru)
GB (2) GB1411495A (ru)
HU (2) HU166517B (ru)
IL (2) IL43003A0 (ru)
NL (2) NL7311301A (ru)
PL (2) PL94510B1 (ru)
RO (2) RO62918A (ru)
SU (11) SU484679A3 (ru)
ZA (3) ZA735629B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457275A1 (fr) * 1979-05-21 1980-12-19 Fabre Sa Pierre Acides p-biphenyl-4 methyl-2 buten-3 oiques utiles dans le traitement des rhumatismes
RU2686489C1 (ru) * 2018-12-27 2019-04-29 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет (СПбГУ)" Способ получения α-диазокарбонильных соединений в водной среде

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2128277B2 (ru) * 1970-05-05 1979-06-22 Rorer Inc William H
BE776316R (fr) * 1971-03-10 1972-06-06 Rorer Inc William H Nouveaux derives d'acides phenyl-acetiques substitues et procede pour leur

Also Published As

Publication number Publication date
IL43004A0 (en) 1973-11-28
JPS49124051A (ru) 1974-11-27
BE803734A (fr) 1974-02-18
RO62917A (fr) 1978-02-15
IL43003A0 (en) 1973-11-28
CS165385B2 (ru) 1975-12-22
BG22069A3 (ru) 1976-11-25
AT323144B (de) 1975-06-25
SU554810A3 (ru) 1977-04-15
GB1411495A (en) 1975-10-29
BG21197A3 (ru) 1976-03-20
BE803733A (fr) 1974-02-18
ES417884A1 (es) 1976-03-16
AT323143B (de) 1975-06-25
ATA711273A (de) 1975-06-15
AU5930973A (en) 1975-02-20
BG21844A3 (ru) 1976-09-20
SU520907A3 (ru) 1976-07-05
SU511847A3 (ru) 1976-04-25
CS165387B2 (ru) 1975-12-22
NL7311300A (ru) 1974-02-19
ZA735628B (en) 1975-04-30
CS165386B2 (ru) 1975-12-22
AU476340B2 (en) 1976-09-16
DD107901A5 (ru) 1974-08-20
GB1410852A (en) 1975-10-22
FR2196168A1 (ru) 1974-03-15
CH588435A5 (ru) 1977-05-31
SU484679A3 (ru) 1975-09-15
NL7311301A (ru) 1974-02-19
DE2240441A1 (de) 1974-02-28
ZA735616B (en) 1976-01-28
BE803732A (fr) 1974-02-18
AT328427B (de) 1976-03-25
HU166516B (ru) 1975-03-28
SU520030A3 (ru) 1976-06-30
JPS49124052A (ru) 1974-11-27
SU552021A3 (ru) 1977-03-25
FR2196167A1 (ru) 1974-03-15
ES432465A1 (es) 1976-11-16
SU538658A3 (ru) 1976-12-05
PL90397B1 (ru) 1977-01-31
RO62918A (fr) 1978-04-15
ES432464A1 (es) 1977-02-16
SU482039A3 (ru) 1975-08-25
SU561505A3 (ru) 1977-06-05
ES417883A1 (es) 1976-11-16
DD108071A5 (ru) 1974-09-05
FR2196168B1 (ru) 1977-02-25
AU5930873A (en) 1975-02-20
ZA735629B (en) 1976-01-28
HU166517B (ru) 1975-03-28
SU577967A3 (ru) 1977-10-25
PL94510B1 (pl) 1977-08-31
FR2196167B1 (ru) 1977-04-15

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