SU506298A3 - Способ получени производных изихинолинтеофиллина - Google Patents

Способ получени производных изихинолинтеофиллина

Info

Publication number
SU506298A3
SU506298A3 SU1999306A SU1999306A SU506298A3 SU 506298 A3 SU506298 A3 SU 506298A3 SU 1999306 A SU1999306 A SU 1999306A SU 1999306 A SU1999306 A SU 1999306A SU 506298 A3 SU506298 A3 SU 506298A3
Authority
SU
USSR - Soviet Union
Prior art keywords
izikhinolinteofillina
obtaining derivatives
derivatives
obtaining
acetic acid
Prior art date
Application number
SU1999306A
Other languages
English (en)
Inventor
Сентмиклоши Петер
Месарош Золтан
Тардош Ласло
Хермец Иштван
Эрдельи Илона
Давид Агоштон
Вашвари Лелле
Херват Агнеш
Original Assignee
Хиноин Дьедьсер Еш Ведьесети Термекек Дьяра(Инопредприятие)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хиноин Дьедьсер Еш Ведьесети Термекек Дьяра(Инопредприятие) filed Critical Хиноин Дьедьсер Еш Ведьесети Термекек Дьяра(Инопредприятие)
Application granted granted Critical
Publication of SU506298A3 publication Critical patent/SU506298A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Description

1
Изобретение относитс  к способу получешм новых производных изохинолинтеофиллина, а именно новых солей дигидро- и тетрагидроизохинолинтеофиллин -7- уксусной кислоты, которые превосход т по своим свойствам соль папаверина и теофиллин -7- уксусной кислоты и могут найти применение в медицине.
Предлагаемый способ получени  соединений общей формулы
R
10 CHj-COO V о,Л/
20
сн, где R, X и Z - как указано выше, обрабатывают теофиллинуксусной кислотой формулы С СН -СООН 2ЧмЛ.1| г o.V
где R водородилиС -Сю - алкоксигруппа;
Z и X - водород или вместе образуют валентную св зь, зазслючаетс  в том, что соединение общей формулы
в присутствии растворител  например уксусной кислоты.
Когда Z и X образуют валентную св зь, .целевое 25 соединение может находитьс  в двух формах:
SU1999306A 1973-01-25 1974-01-24 Способ получени производных изихинолинтеофиллина SU506298A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI1333A HU167246B (ru) 1973-01-25 1973-01-25

Publications (1)

Publication Number Publication Date
SU506298A3 true SU506298A3 (ru) 1976-03-05

Family

ID=10994468

Family Applications (1)

Application Number Title Priority Date Filing Date
SU1999306A SU506298A3 (ru) 1973-01-25 1974-01-24 Способ получени производных изихинолинтеофиллина

Country Status (12)

Country Link
US (1) US4035366A (ru)
JP (1) JPS6043351B2 (ru)
BE (1) BE810145A (ru)
CA (1) CA1018160A (ru)
DE (1) DE2403122A1 (ru)
ES (1) ES422694A1 (ru)
FR (1) FR2221134B1 (ru)
GB (1) GB1417542A (ru)
HU (1) HU167246B (ru)
IL (1) IL44056A (ru)
SU (1) SU506298A3 (ru)
YU (1) YU19274A (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368277A1 (fr) * 1976-10-21 1978-05-19 Sobio Lab Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique
FR2377385A2 (fr) * 1977-01-12 1978-08-11 Sobio Lab Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique
JPS614663U (ja) * 1984-06-13 1986-01-11 日輪ゴム工業株式会社 ゲ−ム用ボ−ル
HU194179B (en) * 1985-10-03 1988-01-28 Chinoin Gyogyszer Es Vegyeszet Process for production of 1-/3',4'-dietoxi-benzil/-1,6,7-dietoxi-3,4-dihydro-izoquinolinine-teophilin-7-acetate and their new cristallic monohydrate
HU197207B (en) * 1985-12-04 1989-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical comprising 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydro-isoquinolinium-theophylline-7-acetate or its monohydrate as active ingredient
JPS6384261U (ru) * 1986-11-19 1988-06-02
JPS63154049U (ru) * 1987-03-28 1988-10-11
JPS63160864U (ru) * 1987-04-08 1988-10-20
HUT60926A (en) 1991-04-12 1992-11-30 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition suitable for reducing or preventing increased thrombocyte-aggregation capability
JP3276762B2 (ja) * 1993-12-28 2002-04-22 日本臓器製薬株式会社 イソキノリン誘導体を含有する医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2975E (fr) 1903-12-12 1904-07-29 Francois Gaston Petit Perfectionnements aux fers à repasser
FR1369374A (fr) * 1963-04-26 1964-08-14 Agrologique Francaise Soc Dérivés alcaloïdes de l'acide théophylline-acétique et leur procédé de fabrication
FR2975M (fr) * 1963-09-02 1964-11-30 Agrologique Francaise Soc Nouveaux médicaments a base de dérivés alcaloides de l'acide théophylline-acétique.
FR3625M (fr) * 1964-05-14 1965-10-18 Gerda Lab Médicament constitué par des dérivés de l'acide théophylline-acétique.

Also Published As

Publication number Publication date
CA1018160A (en) 1977-09-27
GB1417542A (en) 1975-12-10
JPS6043351B2 (ja) 1985-09-27
JPS5046818A (ru) 1975-04-25
DE2403122A1 (de) 1974-08-01
BE810145A (fr) 1974-05-16
FR2221134A1 (ru) 1974-10-11
DE2403122C2 (ru) 1990-03-22
HU167246B (ru) 1975-09-27
US4035366A (en) 1977-07-12
FR2221134B1 (ru) 1976-09-03
YU19274A (en) 1983-01-21
IL44056A (en) 1977-01-31
ES422694A1 (es) 1976-09-01
AU6477874A (en) 1975-07-24

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