SU544370A3 - Способ получени производных циклопропилфенилпирролидина или их солей - Google Patents

Способ получени производных циклопропилфенилпирролидина или их солей

Info

Publication number
SU544370A3
SU544370A3 SU2063054A SU2063054A SU544370A3 SU 544370 A3 SU544370 A3 SU 544370A3 SU 2063054 A SU2063054 A SU 2063054A SU 2063054 A SU2063054 A SU 2063054A SU 544370 A3 SU544370 A3 SU 544370A3
Authority
SU
USSR - Soviet Union
Prior art keywords
derivatives
salts
cyclopropylphenylpyrrolidine
preparing
general formula
Prior art date
Application number
SU2063054A
Other languages
English (en)
Inventor
Телон Жан-Мари
Original Assignee
Эксашими (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эксашими (Фирма) filed Critical Эксашими (Фирма)
Application granted granted Critical
Publication of SU544370A3 publication Critical patent/SU544370A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ЦИКЛОПЮПИЛФЕНИЛ ПИРРОЛИДИНА ИЛИ ИХ СОЛЕЙ
.1
Изобретение относитс  к шособу получени  новых производных циклопропилфенилпирролидаиа , которые обладают высокой биологической активностью и могут найти применение в фармацевтической промышлености.
Известны производные циклопропилфенилпирролидина- 1 общей формулы
где R и RI по отдельности представл ют водород , галоген, низший алкил, низший алкоксил, трифторметил или гидроксил и могут находитьс  в положении мета- или пара-, или R и RI вместе 5 представл ют диоксиметилен;
RI - водород или метил,
а также их сол х, обладающих высокой биологической активностью..
Предлагаетс  способ получени  производных 0 циклопропилфеиилпирролидина общей формулы 1 или их солей, заключающийс  в том, что нитропентанон общей формулы
где R представл ет алкил,
обладающие биологической активностью.
В то же врем  в литературе отсутствуют сведени  о производных циклопропилфенилпирро идина общей формулы
V-CH-CHo-С- |
I
I II

Claims (1)

1. Патент ФРГ№1 914925. кл.C07d, 1969.
SU2063054A 1973-09-27 1974-09-26 Способ получени производных циклопропилфенилпирролидина или их солей SU544370A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4539573A GB1474907A (en) 1973-09-27 1973-09-27 Pyrolidine derivatives

Publications (1)

Publication Number Publication Date
SU544370A3 true SU544370A3 (ru) 1977-01-25

Family

ID=10437065

Family Applications (1)

Application Number Title Priority Date Filing Date
SU2063054A SU544370A3 (ru) 1973-09-27 1974-09-26 Способ получени производных циклопропилфенилпирролидина или их солей

Country Status (20)

Country Link
US (1) US4005103A (ru)
JP (1) JPS5076052A (ru)
AR (1) AR209281A1 (ru)
AT (1) AT336601B (ru)
BE (1) BE820191A (ru)
CA (1) CA1025456A (ru)
CH (1) CH593255A5 (ru)
CS (1) CS188203B2 (ru)
DD (1) DD114072A5 (ru)
DE (1) DE2446317A1 (ru)
DK (1) DK506474A (ru)
ES (1) ES430394A1 (ru)
FR (1) FR2245361B1 (ru)
GB (1) GB1474907A (ru)
HU (1) HU170007B (ru)
NL (1) NL7412868A (ru)
NO (1) NO743281L (ru)
SE (1) SE389108B (ru)
SU (1) SU544370A3 (ru)
ZA (1) ZA745927B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182729A (en) * 1972-06-22 1980-01-08 Sterling Drug Inc. Arylvinyl cyclopropyl ketones
US4206230A (en) * 1978-11-13 1980-06-03 Mobil Oil Corporation Phenyl cyclopropyl ketone insecticides
AU2002326806B2 (en) * 2001-08-29 2007-07-19 Endo Pharmaceuticals, Inc. Analgetic pyrroline derivatives
US20070129434A1 (en) * 2002-08-29 2007-06-07 Richard Smith-Carliss Analgesics and methods of use
US20060074083A1 (en) * 2004-10-05 2006-04-06 Merz Pharma Gmbh & Co. Kgaa Cyclic and acyclic propenones for treating CNS disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135766A (en) * 1961-10-03 1964-06-02 Mead Johnson & Co 3-substituted-3-pyrrolidinols
US3452015A (en) * 1967-07-12 1969-06-24 Lilly Co Eli Synthesis of beta,beta-alkyl pyrrolidines

Also Published As

Publication number Publication date
AR209281A1 (es) 1977-04-15
NO743281L (ru) 1975-04-28
BE820191A (fr) 1975-01-16
NL7412868A (nl) 1975-04-02
CH593255A5 (ru) 1977-11-30
CA1025456A (en) 1978-01-31
SE7412161L (ru) 1975-04-01
AU7332474A (en) 1976-03-18
SE389108B (sv) 1976-10-25
FR2245361A1 (ru) 1975-04-25
ZA745927B (en) 1975-10-29
DD114072A5 (ru) 1975-07-12
JPS5076052A (ru) 1975-06-21
ATA765574A (de) 1976-09-15
CS188203B2 (en) 1979-02-28
HU170007B (ru) 1977-03-28
ES430394A1 (es) 1976-10-16
US4005103A (en) 1977-01-25
FR2245361B1 (ru) 1977-11-04
GB1474907A (en) 1977-05-25
AT336601B (de) 1977-05-10
DE2446317A1 (de) 1975-04-10
DK506474A (ru) 1975-06-02

Similar Documents

Publication Publication Date Title
NL930102I2 (nl) Nieuwe para-gesubstitueerde 3-fenoxy-1-alkylamino-propanol-2-en met beta-receptor blokkerende eigenschappen.
RO78465A (ro) Procedeu de preparare a unor derivati ai acizilor 1,2-benzizoxazolcarboxilici
AR207766A1 (es) Procedimiento para la preparacion de 6,7-dimetoxi-4-amino-2-(4-(2-furoil)-piperazin-1-il)quinazolina
PT64673B (fr) Procede pour la preparation de nouvelles perhaloalcoylamidines substituees utilisees comme stimulants cardiaques
ES396213A1 (es) Procedimiento para la preparacion de derivados de piperazi-na racemicos u opticamente activos.
SU544370A3 (ru) Способ получени производных циклопропилфенилпирролидина или их солей
AR211938A1 (es) Procedimiento para preparar derivados de acidos 4-(3,5-diterbutil-4-hidroxi-fenilacilamino)-fenoxialquilcarboxilicos
BE811521A (fr) Procede de preparation de derives d'acides 7-acylamino-desacetoxy cephalosporaniques
MX3765E (es) Procedimiento para la preparacion de derivados de piperidina
ATE149507T1 (de) Lösliche, nichttoxische derivate von basischen polyenmakroliden, ihre herstellung und verwendung
CH612427A5 (en) Process for the preparation of heterocyclic compounds substituted by acylamino groups
AR202416A1 (es) Procedimiento para la preparacion de derivados de 1-aril-n-dialquilaminoalquil 3, 4-dihidro-2 (1h)-isoquinolincarboxamidas
ES454084A1 (es) Procedimiento para la preparmacion de n-(r-tetrahidrofurfu- ril)-noroximorfona y n-(s-tetrahidrofurfuril)-noroximorfona nuevas.
OA04784A (fr) Nouveau procédé de préparation de benzamides 2,5 disubstitués.
SE387625B (sv) Sett for framstellning av foreningar med den allmenna formeln r'-c-c-r?722, varvid foreningar med den allmenna formeln r'-c-ch omsettes med foreningar med den allmenna formeln x-r'722, der x betecknar halogen
BG44203A3 (en) Method for preparing of 2- oxyindol- 1- carboxamides
BE825156A (fr) Procede de preparation de derives d'acides 7-amino,
SE7708686L (sv) Mellanprodukter och forfarande for framstellning derav
SE402775B (sv) Analogiforfarande for framstellning av spasmolytiskt verksamma 3-dietylamino-2,2-dimetylpropyl-5-(substituerad fenyl)-2-furoat
DK135574B (da) Fremgangsmåde til fremstilling af benzylaminderivater eller fysiologisk anvendelige syreadditionssalte heraf.
BE1000719A4 (fr) Derives de 3-(hydroxymethyl)-isoquinoleine, procede pour les preparer et compositions pharmaceutiques les contenant.
ES407866A1 (es) Procedimiento para la obtencion de n - (dietilaminoetil) - 2 - metoxi - 5 - metilsulfonil - benzamida.
ES495651A0 (es) Procedimiento para la preparacion de 10-bromosandwicina y 10-bromoisosandwicina
HU171836B (hu) Sposob poluchenija proizvodnykh tiazolo/5,4-f/khinolin-8-karbonovoj kisloty
AR204834A1 (es) Procedimiento para la preparacion de 2-(n-butilo normal-butilo terciario-amino)-2',6'-acetoxilidida