GB1395764A - Cytidines and related compounds - Google Patents

Cytidines and related compounds

Info

Publication number
GB1395764A
GB1395764A GB2011572A GB2011572A GB1395764A GB 1395764 A GB1395764 A GB 1395764A GB 2011572 A GB2011572 A GB 2011572A GB 2011572 A GB2011572 A GB 2011572A GB 1395764 A GB1395764 A GB 1395764A
Authority
GB
United Kingdom
Prior art keywords
alkyl
group
hydrogen
sugar group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2011572A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB1395764A publication Critical patent/GB1395764A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
GB2011572A 1971-05-04 1972-05-01 Cytidines and related compounds Expired GB1395764A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2122991A DE2122991C2 (de) 1971-05-04 1971-05-04 Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden

Publications (1)

Publication Number Publication Date
GB1395764A true GB1395764A (en) 1975-05-29

Family

ID=5807376

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2011572A Expired GB1395764A (en) 1971-05-04 1972-05-01 Cytidines and related compounds

Country Status (8)

Country Link
US (1) US3891623A (enExample)
BE (1) BE783026A (enExample)
CH (1) CH579585A5 (enExample)
CS (1) CS171723B2 (enExample)
DE (1) DE2122991C2 (enExample)
FR (1) FR2135249B1 (enExample)
GB (1) GB1395764A (enExample)
NL (1) NL7206058A (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4090021A (en) * 1971-10-08 1978-05-16 Schering Aktiengesellschaft Process for the production of N6 -substituted adenosine nucleotides and products resulting therefrom
DE2508312A1 (de) * 1975-02-24 1976-09-02 Schering Ag Neues verfahren zur herstellung von nucleosiden
DE2514275A1 (de) * 1975-03-27 1976-10-14 Schering Ag Verfahren zur herstellung von n- (polysaccharidyl)-stickstoffheterocyclen, insbesondere von pyrimidin- oder purinbasen
US4118484A (en) * 1976-03-29 1978-10-03 The Upjohn Company Method of treating rheumatoid arthritis
DE2621645C3 (de) * 1976-05-13 1981-08-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von Aminoderivaten von N-Heterocyclen
GB1601020A (en) 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
US4754026A (en) * 1985-06-04 1988-06-28 Takeda Chemical Industries, Ltd. Conversion of uracil derivatives to cytosine derivatives
FR2590255B1 (fr) * 1985-11-19 1987-12-24 Rhone Poulenc Sante Procede de preparation de derives de la pteridine
US4788181A (en) * 1986-09-29 1988-11-29 The United States Of America As Represented By The Department Of Health And Human Services 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
US6432924B1 (en) 1993-12-26 2002-08-13 East Carolina University Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
RU98113785A (ru) * 1995-12-22 2000-06-10 Ист Каролина Юниверсити (US) Агент и способ лечения заболеваний, связанных с чрезмерной экспрессией цитидиндезаминазы или дезоксицитидинзаминазы
US7291463B2 (en) * 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US6864059B2 (en) * 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7468243B2 (en) * 2001-03-12 2008-12-23 Affymetrix, Inc. 2-aminopyrimidin-4-one nucleic acid labeling compounds
US7282327B2 (en) * 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US20040210045A1 (en) * 1996-01-23 2004-10-21 Mcgall Glenn Nucleic acid labeling compounds
EP0880598A4 (en) * 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US7423143B2 (en) * 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US20010018514A1 (en) * 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AP2005003213A0 (en) * 2002-06-28 2005-03-31 Univ Cagliari 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
MXPA05006230A (es) 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
US6943249B2 (en) * 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
WO2004084453A2 (en) * 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
US7595390B2 (en) 2003-04-28 2009-09-29 Novartis Ag Industrially scalable nucleoside synthesis
EP1639121A4 (en) * 2003-06-30 2008-04-16 Idenix Cayman Ltd SYNTHESIS OF BETA-L-2-DESOXYNUCLEOSIDES
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
UA99308C2 (ru) * 2007-09-26 2012-08-10 Маунт Синай Скул Оф Медсин Аналог азацитидина и его применение
ES2774226T3 (es) 2008-05-15 2020-07-17 Celgene Corp Formulaciones orales de análogos de citidina y métodos de uso de los mismos
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1030970A (en) * 1964-05-15 1966-05-25 Inst Mikrobiologii Im Akad D K Method for the preparation of 2', 3', 5'-tri-o-acyl-6-azacytidines
US3328389A (en) * 1964-08-07 1967-06-27 Sankyo Co Process for preparing nucleotide derivatives
US3328388A (en) * 1964-09-02 1967-06-27 Merck & Co Inc Arabinofuranosyl pyrimidines and methods of preparing same
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US3346561A (en) * 1965-10-24 1967-10-10 Merck & Co Inc Pyrimidine 3-deoxynucleosides
US3404144A (en) * 1965-12-23 1968-10-01 Research Corp 1-beta-d-arabinofuranosyl-5-fluorocytosine compounds
DE1795357A1 (de) * 1968-09-18 1972-01-05 Schering Ag 2-Thio-pyrimidin-nucleoside
US3721664A (en) * 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides

Also Published As

Publication number Publication date
DE2122991A1 (de) 1972-11-16
US3891623A (en) 1975-06-24
FR2135249A1 (enExample) 1972-12-15
CS171723B2 (enExample) 1976-10-29
FR2135249B1 (enExample) 1975-10-17
BE783026A (fr) 1972-11-06
DE2122991C2 (de) 1982-06-09
NL7206058A (enExample) 1972-11-07
CH579585A5 (enExample) 1976-09-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee