GB1394859A - N-substituted 1-aminomethylindans - Google Patents
N-substituted 1-aminomethylindansInfo
- Publication number
- GB1394859A GB1394859A GB3468972A GB3468972A GB1394859A GB 1394859 A GB1394859 A GB 1394859A GB 3468972 A GB3468972 A GB 3468972A GB 3468972 A GB3468972 A GB 3468972A GB 1394859 A GB1394859 A GB 1394859A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- compounds
- alkyl
- july
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 N-substituted-1-aminomethylindanes Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical group CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- CMKDJMDGRSJZIS-UHFFFAOYSA-N 2,3-dihydro-1h-indene-1-carbaldehyde Chemical compound C1=CC=C2C(C=O)CCC2=C1 CMKDJMDGRSJZIS-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002445 parasympatholytic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003235 pyrrolidines Chemical class 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2137276A DE2137276A1 (de) | 1971-07-26 | 1971-07-26 | N-substituierte 1-aminomethylindane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1394859A true GB1394859A (en) | 1975-05-21 |
Family
ID=5814830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3468972A Expired GB1394859A (en) | 1971-07-26 | 1972-07-25 | N-substituted 1-aminomethylindans |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3886168A (https=) |
| JP (1) | JPS5824433B1 (https=) |
| AT (1) | AT316534B (https=) |
| BE (1) | BE786748A (https=) |
| CA (1) | CA978184A (https=) |
| CH (1) | CH583169A5 (https=) |
| DE (1) | DE2137276A1 (https=) |
| FR (1) | FR2147209B1 (https=) |
| GB (1) | GB1394859A (https=) |
| NL (1) | NL7209802A (https=) |
| SE (1) | SE411755B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0164697A3 (en) * | 1984-06-09 | 1987-04-29 | Kaken Pharmaceutical Co., Ltd. | Amine derivatives, processes for preparing the same and fungicides containing the same |
| EP0361577A1 (en) * | 1988-09-19 | 1990-04-04 | Akzo N.V. | Tetrahydronaphthalene and indane derivatives |
| US5334628A (en) * | 1984-06-09 | 1994-08-02 | Kaken Pharmaceutical Co., Ltd. | Amine derivatives, processes for preparing the same and fungicides containing the same |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005093A (en) * | 1975-01-20 | 1977-01-25 | Sterling Drug Inc. | 2-Naphthyl-lower-alkylamines |
| US4130646A (en) * | 1975-07-25 | 1978-12-19 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof |
| JPS52133993A (en) * | 1976-04-29 | 1977-11-09 | Takeda Chem Ind Ltd | 1.2-dihydronaphthalene derivatives and method of preparing the same |
| DE2862103D1 (en) * | 1977-08-19 | 1982-11-18 | Sandoz Ag | Propenyl amines, processes for their production and pharmaceutical compositions containing them |
| GB8704572D0 (en) * | 1987-02-26 | 1987-04-01 | Lundbeck & Co As H | Organic compounds |
| DE68909253T2 (de) * | 1988-01-15 | 1994-02-24 | Abbott Lab | 1-Aminomethyl-1,2,3,4-tetrahydronaphthaline und -indane. |
| US5877218A (en) * | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| EP0738149B1 (en) * | 1994-01-10 | 2006-11-29 | Teva Pharmaceutical Industries, Ltd. | 1-aminoindan derivatives and compositions thereof |
| ES2241064T3 (es) | 1996-12-18 | 2005-10-16 | Teva Pharmaceutical Industries, Ltd. | Derivados de aminoindano. |
| US6737547B1 (en) | 1998-12-31 | 2004-05-18 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using N-acyl-1H-aminoindenes |
| JP2003512426A (ja) | 1999-10-27 | 2003-04-02 | テバ ファーマシューティカル インダストリーズ リミティド | 双極性気分障害における躁病の治療のための１−アミノインダンの使用。 |
| US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| ES2632638T3 (es) * | 2005-12-09 | 2017-09-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Ladostigilo de baja dosis para el tratamiento de la deficiencia cognitiva |
| US20070135518A1 (en) * | 2005-12-09 | 2007-06-14 | Marta Weinstock-Rosin | Use of low-dose ladostigil for neuroprotection |
| TW200744576A (en) * | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3706756A (en) * | 1969-02-03 | 1972-12-19 | Ciba Geigy Corp | Aminoalkyl-spirocycloalkanes |
| BE757408A (fr) * | 1969-10-13 | 1971-04-13 | Thomae Gmbh Dr K | Nouveaux butanols tertiaires a constituants basiques |
| US3704323A (en) * | 1969-12-23 | 1972-11-28 | Squibb & Sons Inc | Indane derivatives |
| US3725412A (en) * | 1969-12-29 | 1973-04-03 | Sandoz Ag | Substituted {60 ,{60 ,{65 -triphenyl-aminopropanols |
-
0
- BE BE786748D patent/BE786748A/xx unknown
-
1971
- 1971-07-26 DE DE2137276A patent/DE2137276A1/de active Pending
-
1972
- 1972-07-14 NL NL7209802A patent/NL7209802A/xx not_active Application Discontinuation
- 1972-07-20 US US273456A patent/US3886168A/en not_active Expired - Lifetime
- 1972-07-21 CH CH1092372A patent/CH583169A5/xx not_active IP Right Cessation
- 1972-07-24 SE SE7209669A patent/SE411755B/xx unknown
- 1972-07-25 JP JP47073910A patent/JPS5824433B1/ja active Granted
- 1972-07-25 AT AT637972A patent/AT316534B/de not_active IP Right Cessation
- 1972-07-25 GB GB3468972A patent/GB1394859A/en not_active Expired
- 1972-07-25 CA CA147,926A patent/CA978184A/en not_active Expired
- 1972-07-26 FR FR7226884A patent/FR2147209B1/fr not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0164697A3 (en) * | 1984-06-09 | 1987-04-29 | Kaken Pharmaceutical Co., Ltd. | Amine derivatives, processes for preparing the same and fungicides containing the same |
| US5021458A (en) * | 1984-06-09 | 1991-06-04 | Kaken Pharmaceutical Co., Ltd. | Amine derivatives and fungicides containing the same |
| US5200423A (en) * | 1984-06-09 | 1993-04-06 | Kaken Pharmaceutical Co., Ltd. | Amine derivatives, processes for preparing the same and fungicides containing the same |
| US5334628A (en) * | 1984-06-09 | 1994-08-02 | Kaken Pharmaceutical Co., Ltd. | Amine derivatives, processes for preparing the same and fungicides containing the same |
| EP0361577A1 (en) * | 1988-09-19 | 1990-04-04 | Akzo N.V. | Tetrahydronaphthalene and indane derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5824433B1 (https=) | 1983-05-20 |
| FR2147209B1 (https=) | 1975-10-17 |
| US3886168A (en) | 1975-05-27 |
| SE411755B (sv) | 1980-02-04 |
| CH583169A5 (https=) | 1976-12-31 |
| CA978184A (en) | 1975-11-18 |
| DE2137276A1 (de) | 1973-02-08 |
| AT316534B (de) | 1974-07-10 |
| FR2147209A1 (https=) | 1973-03-09 |
| BE786748A (fr) | 1973-01-26 |
| NL7209802A (https=) | 1973-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |