ES8404333A1 - Un metodo para preparar derivados de fenilpiperazina. - Google Patents

Un metodo para preparar derivados de fenilpiperazina.

Info

Publication number
ES8404333A1
ES8404333A1 ES520439A ES520439A ES8404333A1 ES 8404333 A1 ES8404333 A1 ES 8404333A1 ES 520439 A ES520439 A ES 520439A ES 520439 A ES520439 A ES 520439A ES 8404333 A1 ES8404333 A1 ES 8404333A1
Authority
ES
Spain
Prior art keywords
piperazine derivatives
phenyl piperazine
antiaggressive activity
antiaggressive
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520439A
Other languages
English (en)
Other versions
ES520439A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of ES8404333A1 publication Critical patent/ES8404333A1/es
Publication of ES520439A0 publication Critical patent/ES520439A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO PARA PREPARAR DERIVADOS DE FENIL-PIPERAZINA, FARMACEUTICAMENTE ACTIVOS, DE FORMULA GENERAL (3), EN LA QUE R3 ES UN GRUPO TRIFLUOROMETILO O UN ATOMO DE CLORO; R4 ES UN ATOMO DE HIDROGENO, UN GRUPO METILO O UN GRUPO ETILO; A ES UN GRUPO -CH2- O -CH2-CH2; X ES UN GRUPO -CH2-; Y ES UN GRUPO FCFO O FSO2; Y Z ES UN GRUPO ALCOHILO CON 1 A 4 ATOMOS DE CARBONO O UN GRUPO FENILO, Y SUS SALES DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA: CL-A-X-NR4-Y-Z, EN CUYAS FORMULAS LOS SIMBOLOS TIENENLOS SIGNIFICADOS YA MENCIONADOS.DE APLICACION EN EL TRATAMIENTO DE UN COMPORTAMIENTO INTRA Y EXTRAPUNITIVO Y UN COMPORTAMIENTO AGRESIVO EVIDENTE EN EL HOMBRE Y EN LOS ANIMALES.
ES520439A 1982-03-12 1983-03-09 Un metodo para preparar derivados de fenilpiperazina. Granted ES520439A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8201032 1982-03-12

Publications (2)

Publication Number Publication Date
ES8404333A1 true ES8404333A1 (es) 1984-04-16
ES520439A0 ES520439A0 (es) 1984-04-16

Family

ID=19839409

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520439A Granted ES520439A0 (es) 1982-03-12 1983-03-09 Un metodo para preparar derivados de fenilpiperazina.

Country Status (8)

Country Link
EP (1) EP0089089A1 (es)
JP (1) JPS58180478A (es)
AU (1) AU1233483A (es)
DK (1) DK101683A (es)
ES (1) ES520439A0 (es)
GR (1) GR77944B (es)
IL (1) IL68092A0 (es)
ZA (1) ZA831625B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8501192D0 (en) * 1985-01-17 1985-02-20 Boots Co Plc Therapeutic agents
GB8531071D0 (en) * 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
FR2675802B1 (fr) * 1991-04-26 1993-12-24 Rhone Poulenc Rorer Sa Antiserotonines, leur preparation et les medicaments les contenant.
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
PE20040167A1 (es) * 2002-03-28 2004-05-26 Novartis Ag Amidas del acido sulfamico
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455927A (en) * 1966-11-17 1969-07-15 Smithkline Corp Phenylpiperazinylalkylsulfamides
US3824530A (en) * 1972-12-05 1974-07-16 Amp Inc Installation of electrical connectors on wires intermediate the ends thereof
DE3065026D1 (en) * 1979-05-23 1983-11-03 Beecham Wuelfing Gmbh & Co Kg Phenylsulphonamide derivatives, a process for their preparation and their use as medicines
NL8005132A (nl) * 1980-09-12 1982-04-01 Duphar Int Res Fenylpiperazinederivaten met antiagressieve werking.

Also Published As

Publication number Publication date
DK101683D0 (da) 1983-02-28
ES520439A0 (es) 1984-04-16
ZA831625B (en) 1984-10-31
GR77944B (es) 1984-09-25
DK101683A (da) 1983-09-13
AU1233483A (en) 1983-09-15
IL68092A0 (en) 1983-06-15
JPS58180478A (ja) 1983-10-21
EP0089089A1 (en) 1983-09-21

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