GB1425049A - Substituted 2-hydroxy-2-phenylethyl-amines - Google Patents

Substituted 2-hydroxy-2-phenylethyl-amines

Info

Publication number
GB1425049A
GB1425049A GB2508273A GB2508273A GB1425049A GB 1425049 A GB1425049 A GB 1425049A GB 2508273 A GB2508273 A GB 2508273A GB 2508273 A GB2508273 A GB 2508273A GB 1425049 A GB1425049 A GB 1425049A
Authority
GB
United Kingdom
Prior art keywords
acetoxy
dimethoxy
hydroxy
acetophenone
nhch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2508273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr L Zambeletti SpA
Original Assignee
Dr L Zambeletti SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr L Zambeletti SpA filed Critical Dr L Zambeletti SpA
Publication of GB1425049A publication Critical patent/GB1425049A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1425049 2 - Hydroxy - 2 - phenylethylamines DR L ZAMBELETTI SpA 25 May 1973 [7 Sept 1972] 25082/73 Heading C2C Novel compounds I: in which the R radicals are identical and are H, CH 2 O or OH, R 1 is H, OH or CH 3 O, R 2 is 4- methyl - 1 - piperazinyl, 6 - methylpyrid - 2 - ylamino, cyclohexylamino, 4 - (2 - hydroxyethyl) - 1 - piperazinyl, morpholino, NHCH 3 or NH-n-C 4 H 9 , and R 3 is H or CH 3 , provided that when R 2 is NHCH 3 , R 3 is CH 3 , and when R 2 is NH-n-C 4 H 9 , at least one of R and R 1 is CH 3 O, and their non-toxic acid addition salts, are prepared by reducing an acid addition salt of an aminoketone of Formula II: Starting materials and intermediates.-The following compounds are prepared in the examples: # - (61 - methylpyridyl - 2<SP>1</SP>- amino) - 4- (hydroxy or acetoxy) - acetophenone, # , (N<SP>1</SP>- methylpiperazino) - 3,5 - dimethoxy - 4 - (hydroxy or acetoxy) - acetophenone, 1 - [3<SP>1</SP>,5<SP>1</SP> - dimethoxy- 4<SP>1</SP> - (hydroxy or acetoxy)] - 2 - methylaminopropiophenone, # - chloro - 4 - acetoxyacetophenone, 3,5 - dimethoxy - 4 - (hydroxy or acetoxy) - acetophenone, 3,5 - dimethoxy - 4 - acetoxy- # - bromoacetophenone, 3,5 - dimethoxy - 4 - acetoxy - benzamide, 3,5 - dimethoxy - 4 - acetoxypropiophenone and 3,5 - dimethoxy - 4 - acetoxy- α-bromopropiophenone. Pharmaceutical compositions having hypertensive or hypotensive activity, comprise a compound I or non-toxic addition salt thereof together with a pharmaceutical carrier.
GB2508273A 1972-09-07 1973-05-25 Substituted 2-hydroxy-2-phenylethyl-amines Expired GB1425049A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2891972A IT1044224B (en) 1972-09-07 1972-09-07 2 HYDROXY 2 PHENYLETHYLAMINS REPLACED AS VASOACTIVE SUBSTANCES AND PROCESS FOR THEIR PREPARATION

Publications (1)

Publication Number Publication Date
GB1425049A true GB1425049A (en) 1976-02-18

Family

ID=11224633

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2508273A Expired GB1425049A (en) 1972-09-07 1973-05-25 Substituted 2-hydroxy-2-phenylethyl-amines

Country Status (5)

Country Link
JP (1) JPS4985035A (en)
DE (1) DE2344681A1 (en)
FR (1) FR2198743B1 (en)
GB (1) GB1425049A (en)
IT (1) IT1044224B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006134352A1 (en) * 2005-06-15 2006-12-21 Biosynth As Method for the synthesis of anthocyanins

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128740A (en) * 1980-03-14 1981-10-08 Grelan Pharmaceut Co Ltd Preparation of erythro-2-amino-1-phenylpropanol derivative
AUPN977296A0 (en) * 1996-05-10 1996-06-06 Monash University Pharmaceutical agents
BE1014245A4 (en) * 2001-04-03 2003-07-01 Malak Jean Chemical compounds octopamine derivatives and uses thereof as agonists beta 3-adrenergic.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1143626B (en) * 1968-04-18 1986-10-22 Zambeletti L Dr Spa PROCESS FOR THE MANUFACTURE OF (13.5 DIMETOXY 4 HYDROXY) 2 MONOMETHYLAMINOETHANOL, MEDICATION WITH HYPERTENSIVE ACTION

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006134352A1 (en) * 2005-06-15 2006-12-21 Biosynth As Method for the synthesis of anthocyanins
AU2006258853B2 (en) * 2005-06-15 2012-02-23 Biosynth As Method for the synthesis of anthocyanins
CN101198616B (en) * 2005-06-15 2012-05-23 生物合成股份有限公司 Method for the synthesis of anthocyanins
US8513395B2 (en) 2005-06-15 2013-08-20 Biosynth As Method for the synthesis of anthocyanins
NO338953B1 (en) * 2005-06-15 2016-11-07 Biosynth As Process for the synthesis of anthocyanins

Also Published As

Publication number Publication date
FR2198743A1 (en) 1974-04-05
IT1044224B (en) 1980-03-20
DE2344681A1 (en) 1974-03-21
FR2198743B1 (en) 1977-01-28
JPS4985035A (en) 1974-08-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee