GB1389437A - 1,4-benzodiazepine derivatives and their preparation - Google Patents
1,4-benzodiazepine derivatives and their preparationInfo
- Publication number
- GB1389437A GB1389437A GB3413874A GB3413874A GB1389437A GB 1389437 A GB1389437 A GB 1389437A GB 3413874 A GB3413874 A GB 3413874A GB 3413874 A GB3413874 A GB 3413874A GB 1389437 A GB1389437 A GB 1389437A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- preparation
- formula
- benzodiazepine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 2-pyrimidyl Chemical group 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 235000011054 acetic acid Nutrition 0.000 abstract 1
- 150000001243 acetic acids Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 150000004674 formic acids Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- KLNFAMGHSZQYHR-UHFFFAOYSA-N imidazo[4,5-i][1,2]benzodiazepine Chemical class C1=CC=NN=C2C3=NC=NC3=CC=C21 KLNFAMGHSZQYHR-UHFFFAOYSA-N 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- BRMYZIKAHFEUFJ-UHFFFAOYSA-L mercury diacetate Chemical compound CC(=O)O[Hg]OC(C)=O BRMYZIKAHFEUFJ-UHFFFAOYSA-L 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Polymers & Plastics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16909171A | 1971-08-04 | 1971-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1389437A true GB1389437A (en) | 1975-04-03 |
Family
ID=22614230
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3413874A Expired GB1389437A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3288572A Expired GB1389434A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412474A Expired GB1389435A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412574A Expired GB1389436A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3288572A Expired GB1389434A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412474A Expired GB1389435A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
| GB3412574A Expired GB1389436A (en) | 1971-08-04 | 1972-07-13 | 1,4-benzodiazepine derivatives and their preparation |
Country Status (8)
| Country | Link |
|---|---|
| JP (3) | JPS5714351B1 (OSRAM) |
| AU (1) | AU461139B2 (OSRAM) |
| BE (1) | BE787251A (OSRAM) |
| CH (3) | CH574444A5 (OSRAM) |
| DE (1) | DE2237592C2 (OSRAM) |
| FR (1) | FR2150732B1 (OSRAM) |
| GB (4) | GB1389437A (OSRAM) |
| ZA (1) | ZA724880B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917627A (en) * | 1971-08-04 | 1975-11-04 | Upjohn Co | 6-Substituted 4H-imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines and process for their production |
| FR2183716A1 (en) * | 1972-05-05 | 1973-12-21 | Centre Etd Ind Pharma | Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants |
| ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US3910946A (en) * | 1974-09-12 | 1975-10-07 | Upjohn Co | 4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines |
| CA1060892A (en) * | 1974-11-06 | 1979-08-21 | Parke, Davis And Company | Diazepine compounds and method for their production |
| SE422580B (sv) * | 1975-08-07 | 1982-03-15 | Hoffmann La Roche | Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| WO1994026723A2 (en) * | 1993-05-14 | 1994-11-24 | Genentech, Inc. | ras FARNESYL TRANSFERASE INHIBITORS |
| WO1996023790A1 (de) * | 1995-02-02 | 1996-08-08 | F. Hoffmann-La Roche Ag | Acetylimidazobenzodiazepine |
| EP3160969B1 (en) | 2014-06-26 | 2023-09-13 | The Johns Hopkins University | Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system |
| JP7139323B2 (ja) * | 2016-11-01 | 2022-09-20 | エフ．ホフマン－ラ ロシュ アーゲー | Ｃｎｓ関連疾患を処置するための１，３－ジヒドロ－１，４－ベンゾジアゼピン－２－チオン |
| CN113717176B (zh) * | 2021-10-09 | 2022-07-05 | 上海再启生物技术有限公司 | 一种制备瑞马唑仑的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
-
0
- BE BE787251D patent/BE787251A/xx not_active IP Right Cessation
-
1972
- 1972-07-13 GB GB3413874A patent/GB1389437A/en not_active Expired
- 1972-07-13 GB GB3288572A patent/GB1389434A/en not_active Expired
- 1972-07-13 GB GB3412474A patent/GB1389435A/en not_active Expired
- 1972-07-13 GB GB3412574A patent/GB1389436A/en not_active Expired
- 1972-07-14 ZA ZA724880A patent/ZA724880B/xx unknown
- 1972-07-18 AU AU44673/72A patent/AU461139B2/en not_active Expired
- 1972-07-28 CH CH1130272A patent/CH574444A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1435775A patent/CH584206A5/xx not_active IP Right Cessation
- 1972-07-28 CH CH1435675A patent/CH591488A5/xx not_active IP Right Cessation
- 1972-07-31 DE DE2237592A patent/DE2237592C2/de not_active Expired
- 1972-08-03 FR FR7228090A patent/FR2150732B1/fr not_active Expired
- 1972-08-04 JP JP7775772A patent/JPS5714351B1/ja active Pending
-
1979
- 1979-08-02 JP JP9817279A patent/JPS5547686A/ja active Granted
-
1980
- 1980-06-16 JP JP8030780A patent/JPS5726667A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2150732A1 (OSRAM) | 1973-04-13 |
| JPS5714351B1 (OSRAM) | 1982-03-24 |
| DE2237592C2 (de) | 1985-08-14 |
| JPS5734277B2 (OSRAM) | 1982-07-22 |
| CH574444A5 (OSRAM) | 1976-04-15 |
| CH591488A5 (OSRAM) | 1977-09-30 |
| JPS5726667A (en) | 1982-02-12 |
| AU461139B2 (en) | 1975-05-15 |
| JPS5547686A (en) | 1980-04-04 |
| GB1389436A (en) | 1975-04-03 |
| ZA724880B (en) | 1973-06-27 |
| JPS5732066B2 (OSRAM) | 1982-07-08 |
| GB1389435A (en) | 1975-04-03 |
| DE2237592A1 (de) | 1973-02-15 |
| AU4467372A (en) | 1974-01-24 |
| GB1389434A (en) | 1975-04-03 |
| CH584206A5 (OSRAM) | 1977-01-31 |
| FR2150732B1 (OSRAM) | 1976-04-16 |
| BE787251A (fr) | 1973-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |